AR079569A1 - Derivados de pirrolopiridinil-pirimidin-2-il-amina, procedimientos de preparacion y sus usos - Google Patents
Derivados de pirrolopiridinil-pirimidin-2-il-amina, procedimientos de preparacion y sus usosInfo
- Publication number
- AR079569A1 AR079569A1 ARP100104796A ARP100104796A AR079569A1 AR 079569 A1 AR079569 A1 AR 079569A1 AR P100104796 A ARP100104796 A AR P100104796A AR P100104796 A ARP100104796 A AR P100104796A AR 079569 A1 AR079569 A1 AR 079569A1
- Authority
- AR
- Argentina
- Prior art keywords
- het1
- substituted simply
- hal
- simply
- atoms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Son inhibidores de la proliferacion celular/actividad celular y pueden ser utilizados para el tratamiento de tumores. Reivindicacion 1: Compuestos de la formula (1) en donde significan R1 Br, Het o fenilo sustituido en forma simple por CH2OH, R1' H o Hal, R2 propilo, isopropilo, fenilo mono, bi o trisustituido por Hal y/o A, piridilo pirimidilo o piridazinilo insustituido o sustituido en forma simple por F, A, OA, O u OH, R3 H, metoximetilo, metilo o etilo, R4 A o (CH2)2NA2, R5 H, NH2, NHCH3 o OCH3, R6 H o F, Het pirazolilo, que puede estar reemplazado de manera simple por Het1, A, CHA-CO-Het1, (CH2)2OH, CH2COHet1, tienilmetilo, SO2CH3, CH2OH, CH2CN, (CH2)2CONH(CH2)2NH2, (CH2)2CONH(CH2)2NHCOO-terc-butilo, CH2CH2COHet1, (CH2)2COOH, (CH2)2COOA, (CH2)2CONH2, (CH2)2CONHA, (CH2)2CONA2, C(=CH2)A, ciclopropilmetilo o (CH2)2Het1, piridilo sustituido en forma simple por Het1, pirimidinilo o piridazinilo, Het1 piperidinilo, morfolinilo, pirrolidinilo insustituido o sustituido en forma simple por OH , o piperazinilo insustituido o sustituido en forma simple por acetilo, A alquilo no ramificado o de cadena ramificada, con 1-6 átomos de C, en donde 1-5 átomos de H pueden estar reemplazados por F o cicloalquilo con 3-6 átomos de C, Hal F, CI, Br o I, así como sus sales de uso farmacéutico, tautomeros y estereoisomeros, inclusive sus mezclas en todas las proporciones.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009060174A DE102009060174A1 (de) | 2009-12-23 | 2009-12-23 | Pyrrolopyridinyl-pyrimidin-2-yl-amin-derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR079569A1 true AR079569A1 (es) | 2012-02-01 |
Family
ID=43531962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100104796A AR079569A1 (es) | 2009-12-23 | 2010-12-20 | Derivados de pirrolopiridinil-pirimidin-2-il-amina, procedimientos de preparacion y sus usos |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8575163B2 (es) |
| EP (1) | EP2516431B1 (es) |
| JP (1) | JP5847091B2 (es) |
| CN (1) | CN102666538B (es) |
| AR (1) | AR079569A1 (es) |
| AU (1) | AU2010335628B2 (es) |
| CA (1) | CA2785307C (es) |
| DE (1) | DE102009060174A1 (es) |
| ES (1) | ES2537412T3 (es) |
| WO (1) | WO2011076316A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012058529A2 (en) | 2010-10-28 | 2012-05-03 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| DE102010050558A1 (de) * | 2010-11-05 | 2012-05-10 | Merck Patent Gmbh | 1H-Pyrrolo[2,3-b]pyridinderivate |
| DE102010053347A1 (de) * | 2010-12-03 | 2012-06-06 | Merck Patent Gmbh | 3-Hetaryl-substituierte Pyrrolo[2,3-b] pyridin-derivative als PDK1-Inhibitoren |
| US8809372B2 (en) | 2011-09-30 | 2014-08-19 | Asana Biosciences, Llc | Pyridine derivatives |
| WO2013049559A1 (en) * | 2011-09-30 | 2013-04-04 | Endo Pharmaceuticals Inc. | Pyridine derivatives |
| CN107550905B (zh) * | 2017-09-11 | 2020-07-17 | 浙江永宁药业股份有限公司 | 多取代吡咯并吡啶类化合物的药物用途及其制备方法 |
| SG11202104404XA (en) * | 2018-11-16 | 2021-05-28 | California Inst Of Techn | Erk inhibitors and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| GB0308466D0 (en) | 2003-04-11 | 2003-05-21 | Novartis Ag | Organic compounds |
| RU2403252C2 (ru) * | 2004-03-30 | 2010-11-10 | Вертекс Фармасьютикалз Инкорпорейтед | Азаиндолы, полезные в качестве ингибиторов jak и других протеинкиназ |
| DE102007028515A1 (de) | 2007-06-21 | 2008-12-24 | Merck Patent Gmbh | 6-(Pyrrolopyridinyl)-pyrimidinyl-2-amin-derivate |
| DE102008031517A1 (de) * | 2008-07-03 | 2010-01-07 | Merck Patent Gmbh | Pyrrolopyridinyl-pyrimidin-2-yl-amin-derivate |
-
2009
- 2009-12-23 DE DE102009060174A patent/DE102009060174A1/de not_active Withdrawn
-
2010
- 2010-11-12 CA CA2785307A patent/CA2785307C/en not_active Expired - Fee Related
- 2010-11-12 JP JP2012545114A patent/JP5847091B2/ja not_active Expired - Fee Related
- 2010-11-12 US US13/518,726 patent/US8575163B2/en active Active
- 2010-11-12 WO PCT/EP2010/006911 patent/WO2011076316A1/de active Application Filing
- 2010-11-12 ES ES10778880.4T patent/ES2537412T3/es active Active
- 2010-11-12 AU AU2010335628A patent/AU2010335628B2/en not_active Ceased
- 2010-11-12 CN CN201080058668.1A patent/CN102666538B/zh not_active Expired - Fee Related
- 2010-11-12 EP EP10778880.4A patent/EP2516431B1/de not_active Not-in-force
- 2010-12-20 AR ARP100104796A patent/AR079569A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2537412T3 (es) | 2015-06-08 |
| DE102009060174A1 (de) | 2011-06-30 |
| US20120270871A1 (en) | 2012-10-25 |
| EP2516431B1 (de) | 2015-04-15 |
| AU2010335628A1 (en) | 2012-08-09 |
| WO2011076316A1 (de) | 2011-06-30 |
| JP5847091B2 (ja) | 2016-01-20 |
| JP2013515685A (ja) | 2013-05-09 |
| CN102666538B (zh) | 2015-11-25 |
| AU2010335628B2 (en) | 2016-03-03 |
| EP2516431A1 (de) | 2012-10-31 |
| CN102666538A (zh) | 2012-09-12 |
| US8575163B2 (en) | 2013-11-05 |
| CA2785307C (en) | 2017-10-31 |
| CA2785307A1 (en) | 2011-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |