AR077422A1 - Sales de inhibidores de plk - Google Patents
Sales de inhibidores de plkInfo
- Publication number
- AR077422A1 AR077422A1 ARP100102683A ARP100102683A AR077422A1 AR 077422 A1 AR077422 A1 AR 077422A1 AR P100102683 A ARP100102683 A AR P100102683A AR P100102683 A ARP100102683 A AR P100102683A AR 077422 A1 AR077422 A1 AR 077422A1
- Authority
- AR
- Argentina
- Prior art keywords
- salts
- counterion
- half mole
- solvates
- hydrates
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Virology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Formas cristalinas de la base al igual que solvatos e hidratos e estas formas de sales, un proceso para su preparacion, su utilidad en terapia y las composiciones farmacéuticas que las contienen, también son reivindicadas y descritas en la presente solicitud. Reivindicacion 1: Sales del compuesto 937 con la siguiente formula caracterizadas porque son seleccionadas entre L-tartrato, succinato, fosfato, mesilato, maleato, L-malato, clorhidrato, fumarato (medio mol de contraion), fumarato, citrato (medio mol de contraion), bencenosulfonato y L-aspartato (medio mol de contraion), y sus formas cristalinas, solvatos e hidratos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09166760 | 2009-07-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR077422A1 true AR077422A1 (es) | 2011-08-24 |
Family
ID=42735665
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100102683A AR077422A1 (es) | 2009-07-29 | 2010-07-23 | Sales de inhibidores de plk |
Country Status (9)
Country | Link |
---|---|
US (1) | US8648078B2 (es) |
EP (1) | EP2459196B1 (es) |
JP (1) | JP5851990B2 (es) |
CN (2) | CN103626777B (es) |
AR (1) | AR077422A1 (es) |
ES (1) | ES2553114T3 (es) |
HK (2) | HK1166015A1 (es) |
TW (1) | TW201109334A (es) |
WO (1) | WO2011012534A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009071480A2 (en) * | 2007-12-04 | 2009-06-11 | Nerviano Medical Sciences S.R.L. | Substituted dihydropteridin-6-one derivatives, process for their preparation and their use as kinase inhibitors |
CN102382106A (zh) * | 2010-08-30 | 2012-03-21 | 黄振华 | 苯胺取代的喹唑啉衍生物 |
KR101913441B1 (ko) * | 2010-12-17 | 2018-10-30 | 네르비아노 메디칼 사이언시스 에스.알.엘. | 키나제 억제제로서 치환된 피라졸로-퀴나졸린 유도체 |
EP2668190B1 (en) * | 2011-01-26 | 2016-08-17 | Nerviano Medical Sciences S.r.l. | Tricyclic pyrrolo derivatives, process for their preparation and their use as kinase inhibitors |
WO2012101029A1 (en) * | 2011-01-26 | 2012-08-02 | Nerviano Medical Sciences S.R.L. | Tricyclic derivatives, process for their preparation and their use as kinase inhibitors |
WO2012118802A1 (en) | 2011-02-28 | 2012-09-07 | Transgenomic, Inc. | Kit and method for sequencing a target dna in a mixed population |
PT3129374T (pt) | 2014-04-07 | 2019-03-25 | Netherlands Translational Res Center B V | (5,6-dihidro)pirimido[4,5-e] indolizinas |
US9563488B2 (en) | 2014-05-29 | 2017-02-07 | Apple Inc. | Sharing extension points to allow an application to share content via a sharing extension |
EP3840741A4 (en) | 2018-08-26 | 2022-05-04 | Cardiff Oncology, Inc. | PLK1 TARGET PHOSPHORYLATION STATUS AND TREATMENT OF CANCER WITH PLK1 INHIBITORS |
WO2023104178A1 (zh) * | 2021-12-10 | 2023-06-15 | 山东绿叶制药有限公司 | 蛋白激酶抑制剂及其制备方法和应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4582831A (en) * | 1984-11-16 | 1986-04-15 | Pfizer Inc. | Anti-inflammatory polymorphic monoethanolamine salt of N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide compound, composition, and method of use therefor |
GEP20094664B (en) * | 2003-05-22 | 2009-04-10 | Nerviano Medical Sciences Srl | Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors |
EA014231B1 (ru) * | 2006-02-10 | 2010-10-29 | НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. | Комбинации, включающие ингибитор cdk и антитело фактора роста или антимитотик |
TW200808311A (en) * | 2006-03-30 | 2008-02-16 | Nerviano Medical Sciences Srl | Use of a kinase inhibitor for the treatment of particular resistant tumors |
KR101512284B1 (ko) * | 2006-12-21 | 2015-04-15 | 네르비아노 메디칼 사이언시스 에스.알.엘. | 치환된 피라졸로-퀴나졸린 유도체, 이의 제조방법, 및 키나제 억제제로서의 이의 용도 |
AR076784A1 (es) * | 2009-05-26 | 2011-07-06 | Nerviano Medical Sciences Srl | Combinacion terapeutica que comprende un inhibidor de plk1 y un agente antineoplasico |
-
2010
- 2010-07-22 CN CN201310718586.0A patent/CN103626777B/zh active Active
- 2010-07-22 JP JP2012522114A patent/JP5851990B2/ja active Active
- 2010-07-22 ES ES10737027.2T patent/ES2553114T3/es active Active
- 2010-07-22 CN CN2010800334619A patent/CN102470136B/zh active Active
- 2010-07-22 EP EP10737027.2A patent/EP2459196B1/en active Active
- 2010-07-22 US US13/387,051 patent/US8648078B2/en active Active
- 2010-07-22 WO PCT/EP2010/060659 patent/WO2011012534A1/en active Application Filing
- 2010-07-23 TW TW099124289A patent/TW201109334A/zh unknown
- 2010-07-23 AR ARP100102683A patent/AR077422A1/es unknown
-
2012
- 2012-07-11 HK HK12106801.2A patent/HK1166015A1/xx unknown
-
2014
- 2014-09-12 HK HK14109258.2A patent/HK1195773A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
HK1166015A1 (en) | 2012-10-19 |
CN102470136A (zh) | 2012-05-23 |
CN103626777A (zh) | 2014-03-12 |
US20120157468A1 (en) | 2012-06-21 |
ES2553114T3 (es) | 2015-12-04 |
HK1195773A1 (zh) | 2014-11-21 |
EP2459196B1 (en) | 2015-09-09 |
CN103626777B (zh) | 2015-10-21 |
WO2011012534A1 (en) | 2011-02-03 |
JP2013500299A (ja) | 2013-01-07 |
US8648078B2 (en) | 2014-02-11 |
EP2459196A1 (en) | 2012-06-06 |
CN102470136B (zh) | 2013-12-25 |
JP5851990B2 (ja) | 2016-02-03 |
TW201109334A (en) | 2011-03-16 |
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Legal Events
Date | Code | Title | Description |
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FB | Suspension of granting procedure |