AR076588A1 - VAGINAL RELEASE SYSTEM - Google Patents

VAGINAL RELEASE SYSTEM

Info

Publication number
AR076588A1
AR076588A1 ARP100101718A ARP100101718A AR076588A1 AR 076588 A1 AR076588 A1 AR 076588A1 AR P100101718 A ARP100101718 A AR P100101718A AR P100101718 A ARP100101718 A AR P100101718A AR 076588 A1 AR076588 A1 AR 076588A1
Authority
AR
Argentina
Prior art keywords
drospirenone
membrane
compartment
release system
estrogen
Prior art date
Application number
ARP100101718A
Other languages
Spanish (es)
Inventor
Christine Talling
Svante Holmberg
Antti Keinanen
Original Assignee
Bayer Schering Pharma Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Oy filed Critical Bayer Schering Pharma Oy
Publication of AR076588A1 publication Critical patent/AR076588A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
    • A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
    • A61F6/08—Pessaries, i.e. devices worn in the vagina to support the uterus, remedy a malposition or prevent conception, e.g. combined with devices protecting against contagion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reivindicacion 1: Un sistema de liberacion intravaginal para la liberacion controlada de drospirenona o drospirenona y un estrogeno durante un período de tiempo prolongado, el sistema está caracterizado porque comprende por lo menos un compartimiento, dicho uno o cada compartimiento comprende un nucleo y una membrana que envuelve al nucleo, dicho nucleo y dicha membrana están constituidos esencialmente por una composicion de polímeros igual o diferente, en donde por lo menos un compartimiento comprende: a) drospirenona o un profármaco de la misma; o b) una mezcla de drospirenona o su profármaco y un estrogeno. Reivindicacion 7: Un sistema de liberacion intravaginal de acuerdo con cualquiera de las reivindicaciones 1 a 6, caracterizado porque el nucleo y la membrana están hechos de una composicion de elastomero basada en siloxano que comprende por lo menos un elastomero y posiblemente un polímero no reticulado.Claim 1: An intravaginal release system for the controlled release of drospirenone or drospirenone and an estrogen for a prolonged period of time, the system is characterized in that it comprises at least one compartment, said one or each compartment comprising a core and a membrane that It envelops the nucleus, said nucleus and said membrane are essentially constituted by a composition of the same or different polymers, wherein at least one compartment comprises: a) drospirenone or a prodrug thereof; or b) a mixture of drospirenone or its prodrug and an estrogen. Claim 7: An intravaginal delivery system according to any one of claims 1 to 6, characterized in that the core and membrane are made of a siloxane-based elastomer composition comprising at least one elastomer and possibly a non-crosslinked polymer.

ARP100101718A 2009-05-20 2010-05-18 VAGINAL RELEASE SYSTEM AR076588A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI20095563A FI20095563A (en) 2009-05-20 2009-05-20 Vaginal delivery system

Publications (1)

Publication Number Publication Date
AR076588A1 true AR076588A1 (en) 2011-06-22

Family

ID=40680743

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100101718A AR076588A1 (en) 2009-05-20 2010-05-18 VAGINAL RELEASE SYSTEM

Country Status (4)

Country Link
AR (1) AR076588A1 (en)
FI (1) FI20095563A (en)
TW (1) TW201043208A (en)
WO (1) WO2010133757A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103747765B (en) * 2011-06-06 2016-04-06 橡冠科学研究院 Adopt the drug delivery device of wicking release window
JOP20160267B1 (en) * 2015-12-21 2021-08-17 Bayer Oy Method for Manufacturing a Drug Delivery Device and a Drug Delivery Device Manufactured According to the Method
EP3801378A4 (en) 2018-05-24 2022-02-23 Celanese EVA Performance Polymers LLC Implantable device for sustained release of a macromolecular drug compound
US11690807B2 (en) 2018-05-24 2023-07-04 Celanese Eva Performance Polymers Llc Implantable device for sustained release of a macromolecular drug compound
EP3893884A4 (en) * 2018-12-11 2022-09-14 Lupin Inc. Drug delivery system for ultra-low dose estrogen combinations and methods and uses thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4292965A (en) * 1978-12-29 1981-10-06 The Population Council, Inc. Intravaginal ring
FI95768C (en) * 1993-06-17 1996-03-25 Leiras Oy Intravaginal dosing system
DE19606355A1 (en) * 1996-02-12 1997-08-14 Schering Ag Contraceptive release systems with antiviral and / or antibacterial effects
US20050113350A1 (en) * 2003-11-26 2005-05-26 Bernd Duesterberg Extended use combination comprising estrogens and progestins
US20070111975A1 (en) * 2004-10-07 2007-05-17 Duramed Pharmaceuticals, Inc. Methods of Hormonal Treatment Utilizing Ascending-Dose Extended Cycle Regimens
CA2612415A1 (en) * 2005-06-16 2006-12-28 Warner Chilcott Company, Inc. Estrogen compositions for vaginal administration
US10016442B2 (en) * 2005-06-16 2018-07-10 Allergan Pharmaceuticals International Limited Estrogen compositions for vaginal administration
IE20050723A1 (en) * 2005-10-28 2007-05-30 Patrick T Prendergast Anti-mineralocorticoid therapy of infection
AR066166A1 (en) * 2007-09-21 2009-07-29 Organon Nv DRUG SUPPLY SYSTEM
US20090099149A1 (en) * 2007-10-11 2009-04-16 Wyeth Bioadhesive film
PL2062569T3 (en) * 2007-11-22 2011-10-31 Bayer Oy Vaginal delivery system
EP2062568A1 (en) * 2007-11-22 2009-05-27 Bayer Schering Pharma Oy Vaginal delivery system
TW200927141A (en) * 2007-11-22 2009-07-01 Bayer Schering Pharma Oy Vaginal delivery system
WO2010033188A2 (en) * 2008-09-16 2010-03-25 Playtex Products, Llc. Dosages for menstrual suppression, contraception, and hormone replacement therapy, and methods of administering same
FI121000B (en) * 2008-11-19 2010-06-15 Bayer Schering Pharma Oy Intravaginal delivery system and method for its preparation

Also Published As

Publication number Publication date
FI20095563A0 (en) 2009-05-20
TW201043208A (en) 2010-12-16
WO2010133757A1 (en) 2010-11-25
FI20095563A (en) 2010-11-21

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