AR074801A1 - PHARMACEUTICAL MONOCARBAMS AND COMPOSITIONS CONTAINING THEM - Google Patents

PHARMACEUTICAL MONOCARBAMS AND COMPOSITIONS CONTAINING THEM

Info

Publication number
AR074801A1
AR074801A1 ARP090104977A ARP090104977A AR074801A1 AR 074801 A1 AR074801 A1 AR 074801A1 AR P090104977 A ARP090104977 A AR P090104977A AR P090104977 A ARP090104977 A AR P090104977A AR 074801 A1 AR074801 A1 AR 074801A1
Authority
AR
Argentina
Prior art keywords
hydrogen
methyl
independently selected
pharmaceutical
monocarbams
Prior art date
Application number
ARP090104977A
Other languages
Spanish (es)
Inventor
Mark Edward Flanagan
Manjinder Singh Lall
Steven Joseph Brickner
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AR074801A1 publication Critical patent/AR074801A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

Se refiere a composiciones farmacéuticas y a métodos para tratar infecciones bacterianas usando los compuestos de la fórmula (1). Reivindicación 1: Un compuesto caracterizado porque es de la fórmula (1), o una sal farmacéuticamente aceptable del mismo; en la que: R1 es alquilo C1-6 sustituido con 1 a 3 sustituyentes seleccionados del grupo que consiste en halo, hidroxi, alcoxi C1-6, -NR7R8, -C(=O)NR7R8, y un heterociclo de 3 a 7 miembros, en donde R7 y R8 son independientemente hidrógeno o alquilo C1-6, en donde dicho heterociclo contiene 1 a 3 heteroátomos seleccionados independientemente de O, N, o S; R2 es hidrógeno o metilo; R3 es hidrógeno o metilo; R4 es hidrógeno, deuterio o metilo opcionalmente sustituido con 1 a 3 sustituyentes seleccionados independientemente de F o CI; R5 es hidrógeno, deuterio o metilo opcionalmente sustituido con 1 a 3 sustituyentes seleccionados independientemente de F o CI; R6 es H o -C(=O)OH; y X es C(H), C(F), C(Cl), o N.It refers to pharmaceutical compositions and methods for treating bacterial infections using the compounds of the formula (1). Claim 1: A compound characterized in that it is of the formula (1), or a pharmaceutically acceptable salt thereof; wherein: R1 is C1-6 alkyl substituted with 1 to 3 substituents selected from the group consisting of halo, hydroxy, C1-6 alkoxy, -NR7R8, -C (= O) NR7R8, and a 3- to 7-membered heterocycle , wherein R7 and R8 are independently hydrogen or C1-6 alkyl, wherein said heterocycle contains 1 to 3 heteroatoms independently selected from O, N, or S; R2 is hydrogen or methyl; R3 is hydrogen or methyl; R4 is hydrogen, deuterium or methyl optionally substituted with 1 to 3 substituents independently selected from F or CI; R5 is hydrogen, deuterium or methyl optionally substituted with 1 to 3 substituents independently selected from F or CI; R6 is H or -C (= O) OH; and X is C (H), C (F), C (Cl), or N.

ARP090104977A 2008-12-19 2009-12-18 PHARMACEUTICAL MONOCARBAMS AND COMPOSITIONS CONTAINING THEM AR074801A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13915908P 2008-12-19 2008-12-19

Publications (1)

Publication Number Publication Date
AR074801A1 true AR074801A1 (en) 2011-02-16

Family

ID=41727494

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090104977A AR074801A1 (en) 2008-12-19 2009-12-18 PHARMACEUTICAL MONOCARBAMS AND COMPOSITIONS CONTAINING THEM

Country Status (15)

Country Link
US (2) US8252782B2 (en)
EP (1) EP2379546A1 (en)
JP (1) JP2012512863A (en)
KR (1) KR20110086742A (en)
CN (1) CN102325769A (en)
AR (1) AR074801A1 (en)
AU (1) AU2009329169B2 (en)
CA (1) CA2744756C (en)
IL (1) IL213216A0 (en)
MX (1) MX2011006541A (en)
PA (1) PA8855001A1 (en)
SG (1) SG171781A1 (en)
TW (1) TW201026696A (en)
UY (1) UY32336A (en)
WO (1) WO2010070523A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110086742A (en) * 2008-12-19 2011-07-29 화이자 인코포레이티드 Monocarbams
JP5777725B2 (en) * 2010-11-29 2015-09-09 ファイザー・インク Monobactam
UY34585A (en) * 2012-01-24 2013-09-02 Aicuris Gmbh & Co Kg B-LACTAMIC COMPOUNDS REPLACED WITH AMIDINE, ITS PREPARATION AND USE
CA2999794C (en) 2015-09-23 2023-08-15 Novartis Ag Salts and solid forms of monobactam antibiotic
CN105481812B (en) * 2015-11-30 2020-04-21 重庆天奕恒化科技有限公司 Preparation method of 5-benzyloxy-4-oxo-4H-pyran-2-carboxylic acid
MX2019007613A (en) 2016-12-21 2019-09-04 Aicuris Gmbh & Co Kg Combination therapy with amidine substituted ãŸ-lactam compounds and ãŸ-lactamase inhibitors for infections with antibiotic resistant bacterial strains.
CA3063649A1 (en) 2017-08-02 2019-02-07 Novartis Ag Chemical process for manufacturing monobactam antibiotic and intermediates thereof
WO2019038405A1 (en) 2017-08-23 2019-02-28 Helmholtz-Zentrum für Infektionsforschung GmbH Novel cystobactamide derivatives
CN111328327A (en) 2017-08-31 2020-06-23 北兴化学工业株式会社 1- (N, N-disubstituted carbamoyl) 4- (substituted sulfonyl) triazolin-5-one derivatives, 4- (N, N-disubstituted carbamoyl) 1- (substituted sulfonyl) triazolin-5-one derivatives and herbicides containing these derivatives as active ingredients
JP7280273B2 (en) 2018-01-29 2023-05-23 メッドシャイン ディスカバリー インコーポレイテッド Monocyclic β-Lactam Compounds for Treating Bacterial Infections
WO2021121387A1 (en) 2019-12-19 2021-06-24 南京明德新药研发有限公司 Application of compound in drug preparation

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4587047A (en) * 1981-04-09 1986-05-06 E. R. Squibb & Sons, Inc. 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines
NZ199981A (en) 1981-04-09 1985-08-16 Squibb & Sons Inc 2-oxo-1-(((substituted sulphonyl)amino)carbonyl)azetidines
AU602067B2 (en) 1987-02-11 1990-09-27 Upjohn Company, The Novel n-1 substituted beta-lactams as antibiotics
US5006650A (en) * 1987-02-11 1991-04-09 The Upjohn Company Novel N-1 substituted beta-lactams as antibiotics
KR890700586A (en) * 1987-02-27 1989-04-25 로버어트 에이 아마테이지 Antibacterial beta-lactam containing pyridone carboxylic acid or acid derivative
CA1317298C (en) 1987-03-03 1993-05-04 Upjohn Company (The) Antibiotic sulfonylaminocarbonyl activated .beta.-lactams
US4762922A (en) * 1987-07-01 1988-08-09 Squibb Corporation 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines
US5015737A (en) * 1987-07-22 1991-05-14 The Upjohn Company Therapeutically useful beta-lactams
US4777252A (en) 1987-08-13 1988-10-11 E. R. Squibb & Sons, Inc. 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines
US4889930A (en) 1987-12-21 1989-12-26 E. R. Squibb & Sons, Inc. Process for making 2-oxo-1-((substituted sulfonyl)amino)carbonzyl)azetidines and intermediates used therein
EP0336369A1 (en) 1988-04-04 1989-10-11 E.R. Squibb & Sons, Inc. 3-Acylamino-1-[[[(substituted sulfonyl)amino]carbonyl]amino]2-azetidinones
EP0344707A3 (en) 1988-06-02 1990-04-18 E.R. Squibb & Sons, Inc. 2-Oxo-1-[[(substituted sulfonyl)-amino]carbonyl]-azetidine derivatives
US4959470A (en) 1988-08-17 1990-09-25 E. R. Squibb & Sons, Inc. 2-oxo-[[(substituted sulfonyl)-amino]carbonyl]-azetidines
WO1990003376A1 (en) 1988-09-27 1990-04-05 The Upjohn Company Dihydroxyaryl 4-substituted monocarbams as antibiotics
CA2210787A1 (en) 1997-07-17 1999-01-17 William R. Collier Self-contained work station
AU2008231854B2 (en) 2007-03-23 2013-03-21 Basilea Pharmaceutica Ag Combination medicaments for treating bacterial infections
KR20110086742A (en) * 2008-12-19 2011-07-29 화이자 인코포레이티드 Monocarbams

Also Published As

Publication number Publication date
UY32336A (en) 2010-07-30
KR20110086742A (en) 2011-07-29
US20120289455A1 (en) 2012-11-15
AU2009329169A1 (en) 2010-06-24
US8252782B2 (en) 2012-08-28
JP2012512863A (en) 2012-06-07
IL213216A0 (en) 2011-07-31
CA2744756C (en) 2013-05-28
PA8855001A1 (en) 2010-07-27
SG171781A1 (en) 2011-07-28
MX2011006541A (en) 2011-07-20
EP2379546A1 (en) 2011-10-26
CN102325769A (en) 2012-01-18
AU2009329169B2 (en) 2012-06-28
US8324198B1 (en) 2012-12-04
TW201026696A (en) 2010-07-16
CA2744756A1 (en) 2010-06-24
WO2010070523A1 (en) 2010-06-24
US20100160281A1 (en) 2010-06-24

Similar Documents

Publication Publication Date Title
AR074801A1 (en) PHARMACEUTICAL MONOCARBAMS AND COMPOSITIONS CONTAINING THEM
PE20191541A1 (en) COMPOSITIONS AND METHODS TO INHIBIT THE ACTION OF ARGINASE
BR122012009489B8 (en) process for producing 2-ethoxy-1-{[2-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1h-benzimidazol- (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 7-carboxylate or a salt thereof, pharmaceutical composition, and use
AR086254A1 (en) USEFUL IMIDAZOL DERIVATIVES FOR THE TREATMENT OF ARTHRITIS
PA8852101A1 (en) URACIL CYCLOPROPYLL NUCLEOTIDES
BR112012003592B8 (en) pharmaceutical composition containing quinoline derivative
RU2018121834A (en) NEW BIPHENIL COMPOUND OR ITS SALT
NZ588994A (en) Phenyl and benzodioxinyl substituted indazoles derivatives
AR094277A1 (en) FUMARATE DERIVATIVES REPLACED WITH DEUTERIO
PE20142456A1 (en) OXAZOLIDIN-2-ONA COMPOUNDS AND USES OF THE SAME AS INHIBITORS OF PI3Ks
AR079486A1 (en) HITEROCICLIC COMPOUNDS NITROGENADOS DE OXIMA, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE OF THE SAME FOR THE TREATMENT OF PROLIFERATIVE DISEASES.
AR071283A1 (en) HETEROCICLICAL COMPOUNDS AND USES OF THE SAME
AR065806A1 (en) DERIVATIVES OF QUINOLINA, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USES FOR THE TREATMENT OF Rheumatoid ARTHRITIS.
MA37712B1 (en) Macrocyclic inhibitors of flaviviridae virus
AR085004A1 (en) SELECTIVE INHIBITORS OF GLYCOSIDASES AND USES OF THE SAME
AR073524A1 (en) PI3K A AND M TOR INHIBITING PYRIDOPIRIMIDINONES
BR112015001502A2 (en) azaindazole or diazaindazole derivatives for pain management
EA201390626A1 (en) DERIVATIVES OF HYDROXAMIC ACID AND APPLICATION OF INDICATED DERIVATIVES IN THE TREATMENT OF BACTERIAL INFECTIONS
ES2587304T3 (en) Diaminopyrimidine derivatives and procedures for their preparation
RU2015125591A (en) BENZYL SULPHONAMIDE DERIVATIVES AS RORc MODULATORS
AR084152A1 (en) TRIAZOLOPIRIMIDINE COMPOUNDS AS INHIBITORS OF PDE10A, A PROCESS FOR THEIR OBTAINING, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE IN THE TREATMENT OF CNS DISEASES
JP2012512863A5 (en)
EA201290571A1 (en) AMIDES, APPLICATION OF AMIDES AS SOLVENTS FOR ORGANIC COMPOUNDS, COMPOSITIONS AND EMULSIONS, CONTAINING AMIDES, AND PLANT TREATMENT METHOD
PE20141940A1 (en) TRICYCLIC COMPOUNDS, COMPOSITIONS THAT INCLUDE THEM, AND USES OF THEM
AR076263A1 (en) COMPOSITIONS AND METHODS TO TREAT CANCER. USE.

Legal Events

Date Code Title Description
FA Abandonment or withdrawal