AR070323A1 - Polvo para suspension oral de un macrolido inmunosupresor - Google Patents
Polvo para suspension oral de un macrolido inmunosupresorInfo
- Publication number
- AR070323A1 AR070323A1 ARP090100290A AR070323A1 AR 070323 A1 AR070323 A1 AR 070323A1 AR P090100290 A ARP090100290 A AR P090100290A AR 070323 A1 AR070323 A1 AR 070323A1
- Authority
- AR
- Argentina
- Prior art keywords
- powder
- pharmaceutical compositions
- suspension
- oral suspension
- immunosuppressor
- Prior art date
Links
- 229940059096 powder for oral suspension Drugs 0.000 title abstract 2
- 239000003018 immunosuppressive agent Substances 0.000 title 1
- 239000003120 macrolide antibiotic agent Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 abstract 2
- 239000000725 suspension Substances 0.000 abstract 2
- 229960001967 tacrolimus Drugs 0.000 abstract 2
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 abstract 2
- 244000125300 Argania sideroxylon Species 0.000 abstract 1
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Botany (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Composiciones farmacéuticas que consisten en un polvo para suspension oral de tacrolimus que presenta gran estabilidad como polvo para suspension y también una vez preparada la suspension extemporánea sin la formacion de aglomerados de tipo torta (cake), de buen sabor y agradable aroma. También eI método de preparacion de las composiciones farmacéuticas, procedimiento en seco que consiste en mezclar durante un tiempo adecuado tacrolimus y los excipientes farmacéuticamente aceptables previamente tamizados, y el uso de las composiciones farmacéuticas para el tratamiento y prevencion del rechazo de transplante de árganos y dermatitis atopica.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CL2008000374A CL2008000374A1 (es) | 2008-02-05 | 2008-02-05 | Composicion farmaceutica que comprende un polvo para suspension oral de tacrolimus o una de sus sales, hidratos o solvatos y excipientes farmaceuticamente aceptables; procedimiento de preparacion de dicha composicion farmaceutica; y uso para la preve |
Publications (1)
Publication Number | Publication Date |
---|---|
AR070323A1 true AR070323A1 (es) | 2010-03-31 |
Family
ID=40261181
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090100290 AR070323A1 (es) | 2008-02-05 | 2009-01-29 | Polvo para suspension oral de un macrolido inmunosupresor |
Country Status (15)
Country | Link |
---|---|
US (2) | US20110021553A1 (es) |
EP (1) | EP2248522B1 (es) |
JP (1) | JP2011511059A (es) |
CN (1) | CN101977602A (es) |
AR (1) | AR070323A1 (es) |
BR (1) | BRPI0908072A2 (es) |
CA (1) | CA2714237A1 (es) |
CL (1) | CL2008000374A1 (es) |
CO (1) | CO6660422A2 (es) |
EC (1) | ECSP10010383A (es) |
ES (1) | ES2355884B1 (es) |
MX (1) | MX349358B (es) |
PE (1) | PE20091372A1 (es) |
PT (1) | PT2248522T (es) |
WO (1) | WO2009098649A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2773204A4 (en) | 2011-10-31 | 2015-05-27 | Glaxosmithkline Intellectual Property Ltd | Pazopanib FORMULATION |
CN115804760B (zh) * | 2022-11-23 | 2024-07-30 | 无锡福祈制药有限公司 | 一种他克莫司纳米晶体胶囊剂及其制备方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8608080D0 (en) * | 1986-04-02 | 1986-05-08 | Fujisawa Pharmaceutical Co | Solid dispersion composition |
KR0177158B1 (ko) | 1990-03-01 | 1999-03-20 | 후지사와 도모기찌로 | 면역억제 활성을 갖는 트리사이클릭 화합물 함유 용액 제제 |
CA2054983A1 (en) * | 1990-11-08 | 1992-05-09 | Sotoo Asakura | Suspendible composition and process for preparing the same |
TW570814B (en) * | 1998-03-26 | 2004-01-11 | Fujisawa Pharmaceutical Co | Sustained-release pharmaceutical composition |
AU2004267910B2 (en) | 2003-08-29 | 2011-01-06 | Veloxis Pharmaceuticals, Inc. | Solid dispersions comprising tacrolimus |
ES2376238T3 (es) | 2003-08-29 | 2012-03-12 | Veloxis Pharmaceuticals A/S | Composiciones de liberación modificada comprendiendo tacrolimus. |
KR100866728B1 (ko) | 2004-11-12 | 2008-11-03 | 주식회사종근당 | 타크로리무스를 함유하는 주사제 |
KR20070060144A (ko) * | 2004-12-01 | 2007-06-12 | 테바 기오기스제르갸르 자르트쾨렌 뮈쾨되 레스즈베니타르사사그 | 결정체 마크로라이드의 제조 방법 |
KR100678829B1 (ko) | 2004-12-06 | 2007-02-05 | 한미약품 주식회사 | 타크로리무스의 경구용 마이크로에멀젼 조성물 |
EP1835889A1 (en) * | 2004-12-15 | 2007-09-26 | Elan Pharma International Limited | Nanoparticulate tacrolimus formulations |
KR100678824B1 (ko) * | 2005-02-04 | 2007-02-05 | 한미약품 주식회사 | 용해성이 증가된 무정형 타크로리무스 고체분산체 및 이를포함하는 약제학적 조성물 |
HUP0600097A3 (en) | 2006-02-08 | 2008-07-28 | Richter Gedeon Nyrt | Pharmaceutical compositions comprising tacrolimus and process for their preparation |
US20100003332A1 (en) * | 2006-07-27 | 2010-01-07 | Amorepacific Corporation | Process For Preparing Powder Comprising Nanoparticles of Sparingly Soluble Drug |
CN100515413C (zh) | 2006-09-15 | 2009-07-22 | 杭州平和安康医药科技有限公司 | 他克莫司口服制剂 |
-
2008
- 2008-02-05 CL CL2008000374A patent/CL2008000374A1/es unknown
-
2009
- 2009-01-29 AR ARP090100290 patent/AR070323A1/es unknown
- 2009-02-04 PE PE2009000163A patent/PE20091372A1/es not_active Application Discontinuation
- 2009-02-05 CA CA 2714237 patent/CA2714237A1/en not_active Abandoned
- 2009-02-05 ES ES201050015A patent/ES2355884B1/es not_active Expired - Fee Related
- 2009-02-05 PT PT97087159T patent/PT2248522T/pt unknown
- 2009-02-05 MX MX2010008327A patent/MX349358B/es active IP Right Grant
- 2009-02-05 US US12/866,392 patent/US20110021553A1/en not_active Abandoned
- 2009-02-05 CN CN2009801101026A patent/CN101977602A/zh active Pending
- 2009-02-05 JP JP2010545589A patent/JP2011511059A/ja active Pending
- 2009-02-05 EP EP09708715.9A patent/EP2248522B1/en not_active Not-in-force
- 2009-02-05 WO PCT/IB2009/050455 patent/WO2009098649A1/es active Application Filing
- 2009-02-05 BR BRPI0908072-4A patent/BRPI0908072A2/pt not_active Application Discontinuation
-
2010
- 2010-08-05 EC ECSP10010383 patent/ECSP10010383A/es unknown
- 2010-08-09 CO CO10097188A patent/CO6660422A2/es not_active Application Discontinuation
-
2013
- 2013-03-18 US US13/846,804 patent/US20140088135A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CL2008000374A1 (es) | 2008-04-04 |
EP2248522A4 (en) | 2013-01-09 |
US20140088135A1 (en) | 2014-03-27 |
WO2009098649A1 (es) | 2009-08-13 |
US20110021553A1 (en) | 2011-01-27 |
ECSP10010383A (es) | 2010-11-30 |
CO6660422A2 (es) | 2013-04-30 |
ES2355884B1 (es) | 2012-01-24 |
CN101977602A (zh) | 2011-02-16 |
MX2010008327A (es) | 2010-11-30 |
PE20091372A1 (es) | 2009-10-18 |
JP2011511059A (ja) | 2011-04-07 |
CA2714237A1 (en) | 2009-08-13 |
PT2248522T (pt) | 2017-07-27 |
ES2355884A1 (es) | 2011-04-01 |
BRPI0908072A2 (pt) | 2015-07-21 |
EP2248522A1 (en) | 2010-11-10 |
EP2248522B1 (en) | 2017-05-03 |
MX349358B (es) | 2015-08-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |