AR065864A1 - COMPOSITE OF OXI-CICLOHEXIL-PIPERIDINIL-DIHIDRO-BENZIMIDAZOL-2-ONA PHARMACEUTICAL COMPOSITION THAT IS INCLUDED IN ITS USE FOR THE PREPARATION OF A MEDICINAL PRODUCT AND INTERMEDIARY COMPOUNDS FOR PREPARATION - Google Patents
COMPOSITE OF OXI-CICLOHEXIL-PIPERIDINIL-DIHIDRO-BENZIMIDAZOL-2-ONA PHARMACEUTICAL COMPOSITION THAT IS INCLUDED IN ITS USE FOR THE PREPARATION OF A MEDICINAL PRODUCT AND INTERMEDIARY COMPOUNDS FOR PREPARATIONInfo
- Publication number
- AR065864A1 AR065864A1 ARP080101269A ARP080101269A AR065864A1 AR 065864 A1 AR065864 A1 AR 065864A1 AR P080101269 A ARP080101269 A AR P080101269A AR P080101269 A ARP080101269 A AR P080101269A AR 065864 A1 AR065864 A1 AR 065864A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- alkyl
- optionally substituted
- group
- fluorine atoms
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
Compuesto de oxi-ciclohexil-piperidinil-dihidro-benzimidazol-2-ona caracterizado por la formula (1) o una sal del mismo: en la qué: R4 se selecciona entre el grupo que consiste en hidrogeno y fluor R5 se selecciona entre el grupo que consiste enhidrogeno, ciano, halogeno, alquilo C1-6 (opcionalmente sustituido con uno o más átomos de fluor) y alcoxi C1-6 (opcionalmente sustituido con uno o más átomos de fluor) R6 se selecciona entre el grupo que consiste en hidrogeno, halogeno, ciano,alquilo C1-6 (opcionalmente sustituido con uno o más átomos de fluor), alquilsulfonilo C1-6, cicloalquilo C3-6 (opcionalmente sustituido con uno o más átomos de fluor) y alcoxi C1-6 (opcionalmente sustituido con uno o más átomos de fluor); n seselecciona entre 2, 3 y 4 Q se selecciona entre el grupo que consiste en hidrogeno y alquilo C1-6 y R se selecciona entre el grupo que consiste en alquilo C1-6, cicloalquilo C3-6, cicloalquil C3-6-alquilo C1-6 y alquinilo C2-6, estando cualquiergrupo alquilo o cicloalquilo opcionalmente sustituido con uno o más átomos de fluor. Composicion farmacéutica que lo comprende. Uso de dicho compuesto para la preparacion de un medicamento util para el tratamiento de una afeccion donde serábeneficioso el agonismo de un receptor muscarínico M1, como ser para el tratamiento de un trastorno psicotico o un deterioro cognitivo. Compuestos intermedios para la preparacion de dicho compuesto.Compound of oxy-cyclohexyl-piperidinyl-dihydro-benzimidazol-2-one characterized by the formula (1) or a salt thereof: in which: R4 is selected from the group consisting of hydrogen and fluorine R5 is selected from the group consisting of hydrogen, cyano, halogen, C1-6 alkyl (optionally substituted with one or more fluorine atoms) and C1-6 alkoxy (optionally substituted with one or more fluorine atoms) R6 is selected from the group consisting of hydrogen, halogen, cyano, C1-6 alkyl (optionally substituted with one or more fluorine atoms), C1-6 alkylsulfonyl, C3-6 cycloalkyl (optionally substituted with one or more fluorine atoms) and C1-6 alkoxy (optionally substituted with one or more fluorine atoms); n is selected from 2, 3 and 4 Q is selected from the group consisting of hydrogen and C1-6 alkyl and R is selected from the group consisting of C1-6 alkyl, C3-6 cycloalkyl, C3-6 cycloalkyl-C1 alkyl -6 and C2-6 alkynyl, any alkyl or cycloalkyl group being optionally substituted with one or more fluorine atoms. Pharmaceutical composition that includes it. Use of said compound for the preparation of a medicament useful for the treatment of a condition where agonism of an M1 muscarinic receptor will be beneficial, such as for the treatment of a psychotic disorder or cognitive impairment. Intermediate compounds for the preparation of said compound.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0706167.4A GB0706167D0 (en) | 2007-03-29 | 2007-03-29 | Compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
AR065864A1 true AR065864A1 (en) | 2009-07-08 |
Family
ID=38050489
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080101269A AR065864A1 (en) | 2007-03-29 | 2008-03-27 | COMPOSITE OF OXI-CICLOHEXIL-PIPERIDINIL-DIHIDRO-BENZIMIDAZOL-2-ONA PHARMACEUTICAL COMPOSITION THAT IS INCLUDED IN ITS USE FOR THE PREPARATION OF A MEDICINAL PRODUCT AND INTERMEDIARY COMPOUNDS FOR PREPARATION |
Country Status (6)
Country | Link |
---|---|
AR (1) | AR065864A1 (en) |
CL (1) | CL2008000865A1 (en) |
GB (1) | GB0706167D0 (en) |
PE (1) | PE20090553A1 (en) |
TW (1) | TW200901979A (en) |
WO (1) | WO2008119721A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1960389B1 (en) | 2005-09-30 | 2012-08-15 | Glaxo Group Limited | Compounds which have activity at m1 receptor and their uses in medicine |
ATE492537T1 (en) | 2005-09-30 | 2011-01-15 | Glaxo Group Ltd | COMPOUNDS WITH M1 RECEPTOR ACTIVITY AND THEIR USE IN MEDICINE |
EP1937670A1 (en) | 2005-09-30 | 2008-07-02 | Glaxo Group Limited | Benzimidazolones which have activity at m1 receptor |
GB0718415D0 (en) | 2007-09-20 | 2007-10-31 | Glaxo Group Ltd | Compounds |
JP2010539217A (en) | 2007-09-20 | 2010-12-16 | グラクソ グループ リミテッド | Compounds having activity at the M1 receptor and their use as medicaments |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002515008A (en) * | 1994-10-27 | 2002-05-21 | メルク エンド カンパニー インコーポレーテッド | Muscarinic antagonist |
AU7478396A (en) * | 1995-10-31 | 1997-05-22 | Merck & Co., Inc. | Muscarine agonists |
CA2387535A1 (en) * | 1999-10-13 | 2001-04-19 | Banyu Pharmaceutical Co., Ltd. | Substituted imidazolidinone derivatives |
AU2003245565B2 (en) * | 2002-06-17 | 2008-01-03 | Banyu Pharmaceutical Co., Ltd. | Ophthalmic compositions for treating ocular hypertension |
GB0605785D0 (en) * | 2006-03-22 | 2006-05-03 | Glaxo Group Ltd | Compounds |
GB0605784D0 (en) * | 2006-03-22 | 2006-05-03 | Glaxo Group Ltd | Compounds |
GB0605786D0 (en) * | 2006-03-22 | 2006-05-03 | Glaxo Group Ltd | Compounds |
-
2007
- 2007-03-29 GB GBGB0706167.4A patent/GB0706167D0/en not_active Ceased
-
2008
- 2008-03-26 CL CL200800865A patent/CL2008000865A1/en unknown
- 2008-03-27 WO PCT/EP2008/053601 patent/WO2008119721A1/en active Application Filing
- 2008-03-27 TW TW097110899A patent/TW200901979A/en unknown
- 2008-03-27 AR ARP080101269A patent/AR065864A1/en not_active Application Discontinuation
- 2008-03-27 PE PE2008000559A patent/PE20090553A1/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
PE20090553A1 (en) | 2009-06-06 |
CL2008000865A1 (en) | 2008-10-03 |
GB0706167D0 (en) | 2007-05-09 |
WO2008119721A1 (en) | 2008-10-09 |
TW200901979A (en) | 2009-01-16 |
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