AR065504A1 - COMBINED THERAPY FOR THE TREATMENT OF CHRONIC HEPATITIS B. USE. - Google Patents
COMBINED THERAPY FOR THE TREATMENT OF CHRONIC HEPATITIS B. USE.Info
- Publication number
- AR065504A1 AR065504A1 ARP080100816A ARP080100816A AR065504A1 AR 065504 A1 AR065504 A1 AR 065504A1 AR P080100816 A ARP080100816 A AR P080100816A AR P080100816 A ARP080100816 A AR P080100816A AR 065504 A1 AR065504 A1 AR 065504A1
- Authority
- AR
- Argentina
- Prior art keywords
- antiviral
- treatment
- association
- drugs
- hbv
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
- A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Abstract
Uso de un inmunopreparado de naturaleza proteoliposomal que comprende a la proteína ôSö del virus de la hepatitis B (VHB) obtenida mediante inmunoafinidad para la preparacion de una composicion farmacéutica para el tratamiento de pacientes conhepatitis B cronica mediante un método que consiste en la administracion de dicho inmunopreparado en asociacion con una cantidad efectiva de un antiviral con actividad inhibidora de la replicacion del VHB, caracterizada en que el tratamientoantiviral se realiza en un tiempo igual o inferior a los 6 meses. La administracion de ambos fármacos en asociacion resulta en niveles de eficacia superiores a los obtenidos con los tratamientos convencionales, en cuanto a respuesta terapéuticaclínicamente significativa, caracterizada por una disminucion de la carga viral por debajo de 10.000 copias por mL de suero, normalizacion de las transaminasas y mejoría de los índices de dano histologico. Producto del tiempo en que se administranambos fármacos en asociacion, se elimina la aparicion de mutantes de escape a los antivirales. Reivindicacion 11: Un método para incrementar los niveles de anticuerpos en pacientes de HBC mediante la administracion de un inmunopreparadoproteoliposomal que comprende la proteína ôSö de la envoltura del VHB, obtenida mediante inmunoafinidad, en asociacion con un antiviral perteneciente al grupo de inhibidores de la polimerasa viral utilizados para el tratamiento de la HBC en unperíodo igual o inferior a los 6 meses de tratamiento antiviral.Use of an immunopreparate of proteoliposomal nature comprising the ôSö protein of hepatitis B virus (HBV) obtained by immunoaffinity for the preparation of a pharmaceutical composition for the treatment of patients with chronic hepatitis B by a method consisting of the administration of said immunoprepaired in association with an effective amount of an antiviral with HBV replication inhibitory activity, characterized in that the antiviral treatment is performed in a time equal to or less than 6 months. The administration of both drugs in association results in higher levels of efficacy than those obtained with conventional treatments, in terms of the clinically significant therapeutic response, characterized by a decrease in viral load below 10,000 copies per mL of serum, normalization of transaminases and improvement of histological damage rates. As a result of the time when both drugs are administered in association, the occurrence of escape mutants to antiviral drugs is eliminated. Claim 11: A method for increasing antibody levels in HBC patients by administering an immunopreparate proteoliposomal comprising the ôSö protein of the HBV envelope, obtained by immunoaffinity, in association with an antiviral belonging to the group of viral polymerase inhibitors used for the treatment of HBC in a period equal to or less than 6 months of antiviral treatment.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20070050 | 2007-02-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR065504A1 true AR065504A1 (en) | 2009-06-10 |
Family
ID=39564658
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080100816A AR065504A1 (en) | 2007-02-28 | 2008-02-27 | COMBINED THERAPY FOR THE TREATMENT OF CHRONIC HEPATITIS B. USE. |
Country Status (2)
Country | Link |
---|---|
AR (1) | AR065504A1 (en) |
WO (1) | WO2008104133A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CU23740A1 (en) * | 2009-09-29 | 2011-12-28 | Ct Ingenieria Genetica Biotech | METHOD OF OBTAINING A FORMATION OF ANTIGENS FROM THE HEPATITIS B VIRUS |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ20012544A3 (en) * | 1999-01-12 | 2002-01-16 | Smithkline Beecham Biologicals S.A. | Pharmaceutical packing |
CN1364644A (en) * | 2002-02-05 | 2002-08-21 | 北京多米诺医药研究所 | Immuno liposome therapeutic hepatitis B vaccine and its preparing method |
-
2008
- 2008-02-27 WO PCT/CU2008/000001 patent/WO2008104133A1/en active Application Filing
- 2008-02-27 AR ARP080100816A patent/AR065504A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2008104133A1 (en) | 2008-09-04 |
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Legal Events
Date | Code | Title | Description |
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FB | Suspension of granting procedure |