AR064615A1 - PRODUCTION AND USE OF NON-NATIVE VARIANTS OF DOMAIN 2 OF HUMAN PLACENTA BIKUNINA DESIGNED BY DIRECTED MOLECULAR EVOLUTION - Google Patents

PRODUCTION AND USE OF NON-NATIVE VARIANTS OF DOMAIN 2 OF HUMAN PLACENTA BIKUNINA DESIGNED BY DIRECTED MOLECULAR EVOLUTION

Info

Publication number
AR064615A1
AR064615A1 ARP070105780A ARP070105780A AR064615A1 AR 064615 A1 AR064615 A1 AR 064615A1 AR P070105780 A ARP070105780 A AR P070105780A AR P070105780 A ARP070105780 A AR P070105780A AR 064615 A1 AR064615 A1 AR 064615A1
Authority
AR
Argentina
Prior art keywords
domain
production
bikunina
designed
human placenta
Prior art date
Application number
ARP070105780A
Other languages
Spanish (es)
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39167588&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR064615(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of AR064615A1 publication Critical patent/AR064615A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente se refiere a variantes novedosas del dominio 2 de la bikunina de placenta humana con niveles de expresion mejorados y propiedades inhibidoras de la serina proteasa favorables y su produccion y uso.This refers to novel variants of domain 2 of human placenta bikunin with improved expression levels and favorable serine protease inhibitory properties and their production and use.

ARP070105780A 2006-12-22 2007-12-20 PRODUCTION AND USE OF NON-NATIVE VARIANTS OF DOMAIN 2 OF HUMAN PLACENTA BIKUNINA DESIGNED BY DIRECTED MOLECULAR EVOLUTION AR064615A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06026812 2006-12-22

Publications (1)

Publication Number Publication Date
AR064615A1 true AR064615A1 (en) 2009-04-15

Family

ID=39167588

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070105780A AR064615A1 (en) 2006-12-22 2007-12-20 PRODUCTION AND USE OF NON-NATIVE VARIANTS OF DOMAIN 2 OF HUMAN PLACENTA BIKUNINA DESIGNED BY DIRECTED MOLECULAR EVOLUTION

Country Status (6)

Country Link
AR (1) AR064615A1 (en)
CL (1) CL2007003810A1 (en)
PE (1) PE20081847A1 (en)
TW (1) TW200848425A (en)
UY (1) UY30817A1 (en)
WO (1) WO2008086858A1 (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19725014A1 (en) * 1997-06-13 1998-12-17 Bayer Ag Aprotinin variants with improved properties and bikunins of aprotinin variants

Also Published As

Publication number Publication date
PE20081847A1 (en) 2009-01-11
TW200848425A (en) 2008-12-16
CL2007003810A1 (en) 2008-07-18
WO2008086858A1 (en) 2008-07-24
UY30817A1 (en) 2008-07-31

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