AR064507A1 - NEW CRYSTALLINE SOLID FORMS BASED ON O-DESVENLAFAXINA - Google Patents

NEW CRYSTALLINE SOLID FORMS BASED ON O-DESVENLAFAXINA

Info

Publication number
AR064507A1
AR064507A1 ARP070105872A ARP070105872A AR064507A1 AR 064507 A1 AR064507 A1 AR 064507A1 AR P070105872 A ARP070105872 A AR P070105872A AR P070105872 A ARP070105872 A AR P070105872A AR 064507 A1 AR064507 A1 AR 064507A1
Authority
AR
Argentina
Prior art keywords
solvent
desmethylvenlafaxine
desvenlafaxina
crystalline solid
base form
Prior art date
Application number
ARP070105872A
Other languages
Spanish (es)
Inventor
Iolanda Chamorro
Velez Monica Benito
Original Assignee
Medichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem Sa filed Critical Medichem Sa
Publication of AR064507A1 publication Critical patent/AR064507A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Formas cristalinas polimorficas de forma base de O-desmetilvenlafaxina, que aquí se denominan Formas A y B de forma base de 0-desmetilvenlafaxina, y métodos para preparar y obtener las mismas. Reivindicacion 1: Un proceso para preparar Forma A polimorfica de forma base de O-desmetilvenlafaxina caracterizado porque comprende suspender la forma base de O-desmetilvenlafaxina en por lo menos un solvente. Reivindicacion 2: El proceso de la reivindicacion 1, caracterizado porque dicho por lo menos un solvente es por lo menos uno de: (i) metanol, (ii) acetonitrilo, (iii) agua, (iv) un solvente de éster, (v) un solvente de nitrilo, (vi) mezclas de agua con por lo menos uno de: un solvente de nitrilo, un solvente de amida y un solvente de sulfoxido, y (vii) mezclas de los mismos.Polymorphic crystalline forms of the base form of O-desmethylvenlafaxine, which are here referred to as Forms A and B of the base form of 0-desmethylvenlafaxine, and methods for preparing and obtaining them. Claim 1: A process for preparing polymorphic Form A of the base form of O-desmethylvenlafaxine characterized in that it comprises suspending the base form of O-desmethylvenlafaxine in at least one solvent. Claim 2: The process of claim 1, characterized in that said at least one solvent is at least one of: (i) methanol, (ii) acetonitrile, (iii) water, (iv) an ester solvent, (v ) a nitrile solvent, (vi) mixtures of water with at least one of: a nitrile solvent, an amide solvent and a sulfoxide solvent, and (vii) mixtures thereof.

ARP070105872A 2006-12-22 2007-12-21 NEW CRYSTALLINE SOLID FORMS BASED ON O-DESVENLAFAXINA AR064507A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87658006P 2006-12-22 2006-12-22

Publications (1)

Publication Number Publication Date
AR064507A1 true AR064507A1 (en) 2009-04-08

Family

ID=40298639

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070105872A AR064507A1 (en) 2006-12-22 2007-12-21 NEW CRYSTALLINE SOLID FORMS BASED ON O-DESVENLAFAXINA

Country Status (2)

Country Link
AR (1) AR064507A1 (en)
WO (1) WO2009027766A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8933123B2 (en) 2010-10-08 2015-01-13 Cadila Healthcare Limited Polymorphic forms of O-desmethyl-venlafaxine succinate
CN114478271B (en) * 2021-12-13 2024-05-31 植恩生物技术股份有限公司 Preparation method of desmethylvenlafaxine succinate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE369330T1 (en) * 2001-02-12 2007-08-15 Wyeth Corp O-DESMETHYL-VENLAFAXINE SUCCINATE SALT
JP4445853B2 (en) * 2002-06-10 2010-04-07 ワイス エルエルシー Novel O-desmethylvenlafaxine formate
MX2007016179A (en) * 2006-04-17 2008-03-11 Teva Pharma Polymorphic forms of tegaserod maleate.
WO2008035369A2 (en) * 2006-06-30 2008-03-27 Alembic Limited Novel form of o-desmethyl venlafaxine

Also Published As

Publication number Publication date
WO2009027766A3 (en) 2009-04-23
WO2009027766A2 (en) 2009-03-05

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