AR063120A1 - INJECTABLE DEPOSIT COMPOSITIONS AND PROCESS TO PREPARE THEM - Google Patents
INJECTABLE DEPOSIT COMPOSITIONS AND PROCESS TO PREPARE THEMInfo
- Publication number
- AR063120A1 AR063120A1 ARP070104388A ARP070104388A AR063120A1 AR 063120 A1 AR063120 A1 AR 063120A1 AR P070104388 A ARP070104388 A AR P070104388A AR P070104388 A ARP070104388 A AR P070104388A AR 063120 A1 AR063120 A1 AR 063120A1
- Authority
- AR
- Argentina
- Prior art keywords
- component
- optionally
- active agent
- compositions
- mixing
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Composiciones inyectables de deposito que comprenden al menos un agente activo, opcionalmente con uno o.más excipientes farmacéuticamente aceptables en forma de un sistema de componentes multiples que comprende preferiblemente al menos dos componentes que, al ser suministrados a un individuo que los necesita, forma un deposito de gel in situ o implante en el lugar de la inyeccion tras el contacto con fluidos corporales y exhibe una liberacion prolongada del agente activo. Proceso para preparacion de tales composiciones y métodos para usar dichas composiciones. Reivindicacion 4: Una composicion tal como se reivindica en la reivindicacion 1, caracterizada porque el agente activo se selecciona de un grupo que comprende anastrozola, lentrozola, tamsulosin, donepezil, aripiprazol, olanzapina, risperidona y ziprasidona. Reivindicacion 25: Un proceso para la preparacion de una composicion inyectable tal como se reivindica en la reivindicacion 7, caracterizado por comprender los siguientes pasos: i) mezclar el agente(s) activo con polímero(s) biodegradable para formar micropartículas o nanopartículas, (ii) mezclas las micropartículas o nanopartículas del paso (i) opcionalmente con agente(s) mejoradotes de la viscosidad y/u opcionalmente con uno o más excipientes para formar el componente 1, (iii) mezclar el vehículo líquido opcionalmente con agente(s) mejorador(es) de la viscosidad y/u otros excipientes para formar el componente 2, y (iv) mezclar el componente 1 y el componente 2 para obtener el compuesto deseado antes de la administracion.Injectable depot compositions comprising at least one active agent, optionally with one or more pharmaceutically acceptable excipients in the form of a multi-component system preferably comprising at least two components which, when supplied to an individual in need, forms a gel deposit in situ or implant at the injection site after contact with body fluids and exhibits a prolonged release of the active agent. Process for preparing such compositions and methods for using said compositions. Claim 4: A composition as claimed in claim 1, characterized in that the active agent is selected from a group comprising anastrozole, lentrozole, tamsulosin, donepezil, aripiprazole, olanzapine, risperidone and ziprasidone. Claim 25: A process for the preparation of an injectable composition as claimed in claim 7, characterized by comprising the following steps: i) mixing the active agent (s) with biodegradable polymer (s) to form microparticles or nanoparticles, ( ii) mixing the microparticles or nanoparticles of step (i) optionally with viscosity enhancing agent (s) and / or optionally with one or more excipients to form component 1, (iii) optionally mixing the liquid vehicle with agent (s) viscosity improver (s) and / or other excipients to form component 2, and (iv) mix component 1 and component 2 to obtain the desired compound before administration.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2195DE2006 | 2006-10-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR063120A1 true AR063120A1 (en) | 2008-12-30 |
Family
ID=39268891
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070104388A AR063120A1 (en) | 2006-10-05 | 2007-10-03 | INJECTABLE DEPOSIT COMPOSITIONS AND PROCESS TO PREPARE THEM |
Country Status (17)
Country | Link |
---|---|
US (2) | US20100015195A1 (en) |
EP (2) | EP2089000A2 (en) |
JP (2) | JP2010505821A (en) |
KR (2) | KR20090087441A (en) |
CN (2) | CN101541316A (en) |
AR (1) | AR063120A1 (en) |
AU (2) | AU2007303794A1 (en) |
BR (2) | BRPI0718288A2 (en) |
CA (2) | CA2665105A1 (en) |
CL (1) | CL2007002851A1 (en) |
EA (1) | EA200970348A1 (en) |
IL (2) | IL197947A0 (en) |
MA (2) | MA30814B1 (en) |
MX (2) | MX2009003737A (en) |
RU (1) | RU2009116933A (en) |
TN (2) | TN2009000125A1 (en) |
WO (2) | WO2008041246A2 (en) |
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ATE188375T1 (en) * | 1992-11-17 | 2000-01-15 | Yoshitomi Pharmaceutical | A SUSTAINED RELEASE MICROBLADE CONTAINING AN ANTIPSYCHOTIC AND METHOD FOR THE PRODUCTION THEREOF |
US5650173A (en) * | 1993-11-19 | 1997-07-22 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of biodegradable microparticles containing a biologically active agent |
GB9718986D0 (en) * | 1997-09-09 | 1997-11-12 | Danbiosyst Uk | Controlled release microsphere delivery system |
WO2002058672A2 (en) * | 2001-01-26 | 2002-08-01 | Debio Recherche Pharmaceutique S.A. | Microparticles of biodegradable polymer encapsulating a biologically active substance |
BRPI0213226B1 (en) * | 2001-10-10 | 2016-03-01 | Pf Medicament | process of preparing a pharmaceutical composition in the form of extended release microspheres of a water soluble active ingredient, and, microspheres |
TW200719903A (en) * | 2005-04-19 | 2007-06-01 | Combinatorx Inc | Compositions for the treatment of neoplasms |
-
2007
- 2007-10-03 CA CA002665105A patent/CA2665105A1/en not_active Abandoned
- 2007-10-03 AU AU2007303794A patent/AU2007303794A1/en not_active Abandoned
- 2007-10-03 US US12/444,197 patent/US20100015195A1/en not_active Abandoned
- 2007-10-03 KR KR1020097009284A patent/KR20090087441A/en not_active Application Discontinuation
- 2007-10-03 BR BRPI0718288-0A2A patent/BRPI0718288A2/en not_active Application Discontinuation
- 2007-10-03 CA CA002665101A patent/CA2665101A1/en not_active Abandoned
- 2007-10-03 EP EP07827594A patent/EP2089000A2/en not_active Withdrawn
- 2007-10-03 EA EA200970348A patent/EA200970348A1/en unknown
- 2007-10-03 KR KR1020097009289A patent/KR20090094811A/en active IP Right Grant
- 2007-10-03 EP EP07827598A patent/EP2086505A2/en not_active Withdrawn
- 2007-10-03 JP JP2009531016A patent/JP2010505821A/en not_active Withdrawn
- 2007-10-03 RU RU2009116933/15A patent/RU2009116933A/en not_active Application Discontinuation
- 2007-10-03 AR ARP070104388A patent/AR063120A1/en unknown
- 2007-10-03 CL CL2007002851A patent/CL2007002851A1/en unknown
- 2007-10-03 AU AU2007303793A patent/AU2007303793A1/en not_active Abandoned
- 2007-10-03 MX MX2009003737A patent/MX2009003737A/en not_active Application Discontinuation
- 2007-10-03 CN CNA2007800441356A patent/CN101541316A/en active Pending
- 2007-10-03 JP JP2009531014A patent/JP2010505819A/en not_active Withdrawn
- 2007-10-03 WO PCT/IN2007/000473 patent/WO2008041246A2/en active Application Filing
- 2007-10-03 CN CNA2007800441089A patent/CN101541313A/en active Pending
- 2007-10-03 MX MX2009003735A patent/MX2009003735A/en unknown
- 2007-10-03 US US12/444,257 patent/US20100098735A1/en not_active Abandoned
- 2007-10-03 WO PCT/IN2007/000454 patent/WO2008041245A2/en active Application Filing
- 2007-10-03 BR BRPI0720346-2A2A patent/BRPI0720346A2/en not_active IP Right Cessation
-
2009
- 2009-04-03 TN TNP2009000125A patent/TN2009000125A1/en unknown
- 2009-04-03 TN TNP2009000124A patent/TN2009000124A1/en unknown
- 2009-04-05 IL IL197947A patent/IL197947A0/en unknown
- 2009-04-05 IL IL197946A patent/IL197946A0/en unknown
- 2009-04-27 MA MA31821A patent/MA30814B1/en unknown
- 2009-04-27 MA MA31824A patent/MA30817B1/en unknown
Also Published As
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RU2009116933A (en) | 2010-11-10 |
CL2007002851A1 (en) | 2008-01-18 |
KR20090087441A (en) | 2009-08-17 |
US20100015195A1 (en) | 2010-01-21 |
CA2665105A1 (en) | 2008-04-10 |
BRPI0718288A2 (en) | 2013-11-19 |
CN101541316A (en) | 2009-09-23 |
JP2010505819A (en) | 2010-02-25 |
JP2010505821A (en) | 2010-02-25 |
IL197947A0 (en) | 2009-12-24 |
EP2086505A2 (en) | 2009-08-12 |
AU2007303794A1 (en) | 2008-04-10 |
MA30817B1 (en) | 2009-10-01 |
EP2089000A2 (en) | 2009-08-19 |
MA30814B1 (en) | 2009-10-01 |
CN101541313A (en) | 2009-09-23 |
CA2665101A1 (en) | 2008-04-10 |
TN2009000124A1 (en) | 2010-10-18 |
WO2008041245A2 (en) | 2008-04-10 |
IL197946A0 (en) | 2009-12-24 |
MX2009003735A (en) | 2009-04-22 |
WO2008041245A3 (en) | 2008-05-22 |
WO2008041246A2 (en) | 2008-04-10 |
TN2009000125A1 (en) | 2010-10-18 |
AU2007303793A1 (en) | 2008-04-10 |
WO2008041246A3 (en) | 2008-05-29 |
US20100098735A1 (en) | 2010-04-22 |
KR20090094811A (en) | 2009-09-08 |
EA200970348A1 (en) | 2009-10-30 |
BRPI0720346A2 (en) | 2014-06-24 |
MX2009003737A (en) | 2009-06-16 |
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