AR062452A1 - Composiciones en nanoparticulas - Google Patents
Composiciones en nanoparticulasInfo
- Publication number
- AR062452A1 AR062452A1 ARP070103620A ARP070103620A AR062452A1 AR 062452 A1 AR062452 A1 AR 062452A1 AR P070103620 A ARP070103620 A AR P070103620A AR P070103620 A ARP070103620 A AR P070103620A AR 062452 A1 AR062452 A1 AR 062452A1
- Authority
- AR
- Argentina
- Prior art keywords
- nanoparticles
- polymeric
- therapeutic agent
- therapy
- mammalian subject
- Prior art date
Links
- 239000002105 nanoparticle Substances 0.000 title abstract 7
- 239000000203 mixture Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 3
- 239000011248 coating agent Substances 0.000 abstract 2
- 238000000576 coating method Methods 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229940124597 therapeutic agent Drugs 0.000 abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- 150000001768 cations Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5115—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
- A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Método de terapía basada en nanopartículas para un sujeto mamífero. El método utiliza nanopartículas, y/o nanopartículas con superficies externas que contienen una fraccion de afinidad efectiva para enlazarse específicamente con una superficie biologica hacia la cual se dirige la terapia, y un recubrimiento polimérico hidrofílico. El recubrimiento polimérico hidrofílico se forma de cadenas poliméricas ya sea covalentemente enlazadas o bien adsorbidas superficialmente a los componente poliméricos. Después de que se alcanza una biodistribucion deseada de las nanopartículas, el agente de afinidad se enlaza con la superficie objetivo, y ayuda a internalizar las nanopartículas. Reivindicacion 1: Un método para administrar un agente terapéutico a un sujeto mamífero, el cual comprende administrar sistémicamente al sujeto, una composicion de nanopartículas que comprende una matriz polimérica junto con el cation divalente que contiene un agente terapéutico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82267406P | 2006-08-17 | 2006-08-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR062452A1 true AR062452A1 (es) | 2008-11-12 |
Family
ID=39313134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070103620A AR062452A1 (es) | 2006-08-17 | 2007-08-15 | Composiciones en nanoparticulas |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20100166865A1 (es) |
| EP (1) | EP2054043A2 (es) |
| JP (1) | JP2010501004A (es) |
| KR (1) | KR20090041437A (es) |
| CN (1) | CN101500546A (es) |
| AR (1) | AR062452A1 (es) |
| AU (1) | AU2007319701A1 (es) |
| BR (1) | BRPI0716046A2 (es) |
| CA (1) | CA2659407A1 (es) |
| CL (1) | CL2007002371A1 (es) |
| MX (1) | MX2009001630A (es) |
| PE (1) | PE20080899A1 (es) |
| RU (1) | RU2009109353A (es) |
| TW (1) | TW200815047A (es) |
| WO (1) | WO2008060734A2 (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101661746B1 (ko) | 2008-08-13 | 2016-09-30 | 캘리포니아 인스티튜트 오브 테크놀로지 | 캐리어 나노입자, 그리고 관련된 조성물, 방법 및 시스템 |
| EP2538929A4 (en) | 2010-02-25 | 2014-07-09 | Univ Johns Hopkins | DELAYED RELEASE OF THERAPIES IN A PART OF THE EYE |
| US20130195764A1 (en) * | 2010-04-21 | 2013-08-01 | President And Fellows Of Harvard College | Nanoparticle Targeting to Ischemia for Imaging and Therapy |
| WO2011159951A2 (en) * | 2010-06-17 | 2011-12-22 | Sanford-Burnham Medical Research Institute | Targeting tumor associated macrophages using bisphosphonate-loaded particles |
| WO2012109363A2 (en) | 2011-02-08 | 2012-08-16 | The Johns Hopkins University | Mucus penetrating gene carriers |
| US9907758B2 (en) | 2012-01-09 | 2018-03-06 | Panjab University Department Of Biotechnology (Dbt) | Process for preparing solid lipid sustained release nanoparticles for delivery of vitamins |
| EP2625966A1 (en) | 2012-02-13 | 2013-08-14 | Bionanoplus, S.L. | Nanoparticles comprising a vegetable hydrophobic protein and a water miscible non-volatile organic solvent and uses thereof |
| US10568975B2 (en) * | 2013-02-05 | 2020-02-25 | The Johns Hopkins University | Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof |
| US9468681B2 (en) | 2013-03-01 | 2016-10-18 | California Institute Of Technology | Targeted nanoparticles |
| CA3166758A1 (en) | 2013-05-14 | 2014-11-20 | California Institute Of Technology | Method of delivering therapeutics and imaging agents by nanoparticles that cross the blood brain barrier |
| WO2015175545A1 (en) | 2014-05-12 | 2015-11-19 | The Johns Hopkins University | Highly stable biodegradable gene vector platforms for overcoming biological barriers |
| US10485757B2 (en) | 2015-01-27 | 2019-11-26 | The Johns Hopkins University | Hypotonic hydrogel formulations for enhanced transport of active agents at mucosal surfaces |
| JP6914860B2 (ja) | 2015-07-01 | 2021-08-04 | カリフォルニア インスティチュート オブ テクノロジー | カチオン性粘液酸ポリマー系デリバリーシステム |
| WO2017019792A1 (en) * | 2015-07-27 | 2017-02-02 | The Texas A&M University System | Surface active nanosystems |
| CN109069872B (zh) * | 2015-12-09 | 2021-07-13 | 得克萨斯州大学系统董事会 | 用于治疗疾病的聚合物药物递送系统 |
| EP3806887A4 (en) | 2018-06-13 | 2022-04-06 | California Institute of Technology | Nanoparticles for crossing the blood brain barrier and methods of treatment using the same |
| US12496279B2 (en) | 2019-04-11 | 2025-12-16 | The Johns Hopkins University | Nanoparticles for drug delivery to brain |
| CA3158694A1 (en) | 2019-12-04 | 2021-06-10 | Dantari, Inc. | Methods and compositions for synthesis of therapeutic nanoparticles |
| CN116808202B (zh) * | 2023-04-28 | 2025-08-01 | 苏州大学 | 一种纳米硼递送剂及其制备方法与应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU9799198A (en) * | 1997-10-09 | 1999-05-03 | Vanderbilt University | Micro-particulate and nano-particulate polymeric delivery system |
| US7008645B2 (en) * | 1998-07-14 | 2006-03-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method of inhibiting restenosis using bisphosphonates |
| US6558702B2 (en) * | 2001-04-13 | 2003-05-06 | Alkermes Controlled Therapeutics, Inc. | Method of modifying the release profile of sustained release compositions |
| KR100648515B1 (ko) * | 2004-05-04 | 2006-11-27 | (주)아모레퍼시픽 | 비스포스포네이트-함유 고분자 미립구를 포함하는 골-관련질환 치료 또는 예방용 서방 효과를 갖는 주사제 |
| CA2564719C (en) * | 2004-05-06 | 2011-11-01 | Samyang Corporation | Delivery system for bioactive agents on the basis of a polymeric drug carrier comprising an amphiphilic block polymer and a polylactic acid derivative |
| EA200701997A1 (ru) * | 2005-03-17 | 2008-02-28 | Элан Фарма Интернэшнл Лтд. | Композиция из наночастиц бисфосфоната |
-
2007
- 2007-08-15 BR BRPI0716046-1A2A patent/BRPI0716046A2/pt not_active Application Discontinuation
- 2007-08-15 CA CA002659407A patent/CA2659407A1/en not_active Abandoned
- 2007-08-15 WO PCT/US2007/075968 patent/WO2008060734A2/en not_active Ceased
- 2007-08-15 RU RU2009109353/15A patent/RU2009109353A/ru not_active Application Discontinuation
- 2007-08-15 AR ARP070103620A patent/AR062452A1/es unknown
- 2007-08-15 MX MX2009001630A patent/MX2009001630A/es not_active Application Discontinuation
- 2007-08-15 AU AU2007319701A patent/AU2007319701A1/en not_active Abandoned
- 2007-08-15 CN CNA2007800298042A patent/CN101500546A/zh active Pending
- 2007-08-15 US US12/376,458 patent/US20100166865A1/en not_active Abandoned
- 2007-08-15 EP EP07868331A patent/EP2054043A2/en not_active Withdrawn
- 2007-08-15 PE PE2007001099A patent/PE20080899A1/es not_active Application Discontinuation
- 2007-08-15 KR KR1020097005377A patent/KR20090041437A/ko not_active Withdrawn
- 2007-08-15 JP JP2009524777A patent/JP2010501004A/ja active Pending
- 2007-08-16 CL CL200702371A patent/CL2007002371A1/es unknown
- 2007-08-16 TW TW096130347A patent/TW200815047A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010501004A (ja) | 2010-01-14 |
| KR20090041437A (ko) | 2009-04-28 |
| CL2007002371A1 (es) | 2008-08-08 |
| CA2659407A1 (en) | 2008-05-22 |
| RU2009109353A (ru) | 2010-09-27 |
| WO2008060734A2 (en) | 2008-05-22 |
| TW200815047A (en) | 2008-04-01 |
| MX2009001630A (es) | 2009-02-23 |
| WO2008060734A3 (en) | 2008-07-10 |
| PE20080899A1 (es) | 2008-06-25 |
| EP2054043A2 (en) | 2009-05-06 |
| BRPI0716046A2 (pt) | 2013-09-17 |
| CN101500546A (zh) | 2009-08-05 |
| US20100166865A1 (en) | 2010-07-01 |
| AU2007319701A1 (en) | 2008-05-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |