AR060348A1 - Formas polimorficas de (2r,z)-2-amino-2-ciclohexil-n-(5-(1-metil-1h-pirazol-4-il)-1-oxo-2,6-dihidro-1h-(1,2)diazepino(4,5,6-cd)indol-8-il)acetamida (2r,z)-2--amino-2-ciclohexil-n-(5-(1-metil-1h-pirazol-4-il)-1-oxo-2,6-dihidro-1h-[1,2]diazepino[4,5,6-cd]indol-8-il)acetamida (2r,z)-2--amino-2-ciclohex - Google Patents

Formas polimorficas de (2r,z)-2-amino-2-ciclohexil-n-(5-(1-metil-1h-pirazol-4-il)-1-oxo-2,6-dihidro-1h-(1,2)diazepino(4,5,6-cd)indol-8-il)acetamida (2r,z)-2--amino-2-ciclohexil-n-(5-(1-metil-1h-pirazol-4-il)-1-oxo-2,6-dihidro-1h-[1,2]diazepino[4,5,6-cd]indol-8-il)acetamida (2r,z)-2--amino-2-ciclohex

Info

Publication number
AR060348A1
AR060348A1 ARP070101399A ARP070101399A AR060348A1 AR 060348 A1 AR060348 A1 AR 060348A1 AR P070101399 A ARP070101399 A AR P070101399A AR P070101399 A ARP070101399 A AR P070101399A AR 060348 A1 AR060348 A1 AR 060348A1
Authority
AR
Argentina
Prior art keywords
amino
acetamide
oxo
methyl
diazepino
Prior art date
Application number
ARP070101399A
Other languages
English (en)
Inventor
Raymond Rynberg
Sacha Ninkovic
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AR060348A1 publication Critical patent/AR060348A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Reivindicacion 1: Una forma cristalina de (2R,Z)-2-amino-2-ciclohexil-N-(5-(1-metil-1H-pirazol-4-il)-1-oxo-2,6-dihidro-1H-[1,2]diazepino4,5,6-cd]indol-8-il)acetamida. Reivindicacion 16: Una forma amorfa de (2R,Z)-2-amino-2-ciclohexil-N-(5-(1-metil- 1-H-pirazol-4-il)-1-oxo-2,6-dihidro-1H-[1,2]diazepino[4,5,6-cd]indol-8-il)acetamida. Composiciones farmacéuticas que las contienen y sus usos terapéuticos como gentes anticáncer.
ARP070101399A 2006-04-04 2007-04-03 Formas polimorficas de (2r,z)-2-amino-2-ciclohexil-n-(5-(1-metil-1h-pirazol-4-il)-1-oxo-2,6-dihidro-1h-(1,2)diazepino(4,5,6-cd)indol-8-il)acetamida (2r,z)-2--amino-2-ciclohexil-n-(5-(1-metil-1h-pirazol-4-il)-1-oxo-2,6-dihidro-1h-[1,2]diazepino[4,5,6-cd]indol-8-il)acetamida (2r,z)-2--amino-2-ciclohex AR060348A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78935106P 2006-04-04 2006-04-04

Publications (1)

Publication Number Publication Date
AR060348A1 true AR060348A1 (es) 2008-06-11

Family

ID=38294083

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070101399A AR060348A1 (es) 2006-04-04 2007-04-03 Formas polimorficas de (2r,z)-2-amino-2-ciclohexil-n-(5-(1-metil-1h-pirazol-4-il)-1-oxo-2,6-dihidro-1h-(1,2)diazepino(4,5,6-cd)indol-8-il)acetamida (2r,z)-2--amino-2-ciclohexil-n-(5-(1-metil-1h-pirazol-4-il)-1-oxo-2,6-dihidro-1h-[1,2]diazepino[4,5,6-cd]indol-8-il)acetamida (2r,z)-2--amino-2-ciclohex

Country Status (6)

Country Link
EP (1) EP2004655A1 (es)
JP (1) JP2007277241A (es)
AR (1) AR060348A1 (es)
CA (1) CA2648369A1 (es)
TW (1) TW200806671A (es)
WO (1) WO2007113647A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI548630B (zh) * 2011-04-06 2016-09-11 Ｌｇ生命科學有限公司 １－（３－氰基－１－異丙基－吲哚－５－基）吡唑－４－羧酸結晶型及其製造方法
CN106083849A (zh) 2011-12-31 2016-11-09 百济神州有限公司 作为parp抑制剂的稠合的四元或五元环吡啶并酞嗪酮类化合物
PT2797921T (pt) 2011-12-31 2017-11-14 Beigene Ltd Dihidrodiazepinocarbazolonas tetra ou pentacíclicas fundidas como inibidoras de parp
CN102746211B (zh) * 2012-06-27 2015-05-27 上海泰坦化学有限公司 一种取代吲哚-3-甲醛类化合物的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2309484T3 (es) * 2003-01-09 2008-12-16 Pfizer Inc. Derivados de diazepinoindol como inhibidores de quinasa.

Also Published As

Publication number Publication date
CA2648369A1 (en) 2007-10-11
JP2007277241A (ja) 2007-10-25
EP2004655A1 (en) 2008-12-24
TW200806671A (en) 2008-02-01
WO2007113647A1 (en) 2007-10-11

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