AR057508A1 - Composicion farmaceutica sinergistica de tramadol y clonixinato de lisina - Google Patents
Composicion farmaceutica sinergistica de tramadol y clonixinato de lisinaInfo
- Publication number
- AR057508A1 AR057508A1 ARP070101074A ARP070101074A AR057508A1 AR 057508 A1 AR057508 A1 AR 057508A1 AR P070101074 A ARP070101074 A AR P070101074A AR P070101074 A ARP070101074 A AR P070101074A AR 057508 A1 AR057508 A1 AR 057508A1
- Authority
- AR
- Argentina
- Prior art keywords
- tramadol
- clonixinate
- analgesia
- drugs
- lisine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Composiciones farmacéuticas que contienen dos principios activos siendo uno de ellos un analgésico opiaceo conocido como tramadol o uno de sus enantiomeros o una de sus sales farmacéuticamente aceptables y el otro un analgésico antiinflamatorio no esteroideo conocido como clonixinato de lisina. Cuando se combinan ambos fármacos en proporciones específicas la combinacion produce efectos farmacologicos de analgesia que indican una superaditividad (sinergia), por lo que es posible usar menos cantidad de ambos fármacos para lograr el mismo grado de analgesia que cuando se usan solos. Al disminuir la cantidad de cada fármaco en la combinacion, los efectos colaterales asociados con cada uno de ellos se reducen en numero y grado, por lo tanto esta estrategia terapéutica puede ser una herramienta promisoria en el alivio del dolor agudo moderado a severo con la ventaja de tener menos efectos adversos típicos de opioides tales como predisposicion al abuso, tolerancia, constipacion y depresion respiratoria.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/MX2006/000018 WO2007105929A1 (es) | 2006-03-16 | 2006-03-16 | Composición farmacéutica sinergística de tramadol y clonixinato de lisina |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR057508A1 true AR057508A1 (es) | 2007-12-05 |
Family
ID=38509710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070101074A AR057508A1 (es) | 2006-03-16 | 2007-03-16 | Composicion farmaceutica sinergistica de tramadol y clonixinato de lisina |
Country Status (2)
| Country | Link |
|---|---|
| AR (1) | AR057508A1 (es) |
| WO (1) | WO2007105929A1 (es) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU661723B2 (en) * | 1991-10-30 | 1995-08-03 | Mcneilab, Inc. | Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug |
-
2006
- 2006-03-16 WO PCT/MX2006/000018 patent/WO2007105929A1/es active Application Filing
-
2007
- 2007-03-16 AR ARP070101074A patent/AR057508A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007105929A1 (es) | 2007-09-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |