AR057508A1 - PHARMACEUTICAL SYNERGISTIC COMPOSITION OF TRAMADOL AND LISINE CLONIXINATE - Google Patents

PHARMACEUTICAL SYNERGISTIC COMPOSITION OF TRAMADOL AND LISINE CLONIXINATE

Info

Publication number
AR057508A1
AR057508A1 ARP070101074A ARP070101074A AR057508A1 AR 057508 A1 AR057508 A1 AR 057508A1 AR P070101074 A ARP070101074 A AR P070101074A AR P070101074 A ARP070101074 A AR P070101074A AR 057508 A1 AR057508 A1 AR 057508A1
Authority
AR
Argentina
Prior art keywords
tramadol
clonixinate
analgesia
drugs
lisine
Prior art date
Application number
ARP070101074A
Other languages
Spanish (es)
Inventor
Suarez Graciela De Lo Aguilera
Lora Martha Rosaura Juarez
Original Assignee
Farmaceuticos Rayere S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38509710&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR057508(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Farmaceuticos Rayere S A filed Critical Farmaceuticos Rayere S A
Publication of AR057508A1 publication Critical patent/AR057508A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Composiciones farmacéuticas que contienen dos principios activos siendo uno de ellos un analgésico opiaceo conocido como tramadol o uno de sus enantiomeros o una de sus sales farmacéuticamente aceptables y el otro un analgésico antiinflamatorio no esteroideo conocido como clonixinato de lisina. Cuando se combinan ambos fármacos en proporciones específicas la combinacion produce efectos farmacologicos de analgesia que indican una superaditividad (sinergia), por lo que es posible usar menos cantidad de ambos fármacos para lograr el mismo grado de analgesia que cuando se usan solos. Al disminuir la cantidad de cada fármaco en la combinacion, los efectos colaterales asociados con cada uno de ellos se reducen en numero y grado, por lo tanto esta estrategia terapéutica puede ser una herramienta promisoria en el alivio del dolor agudo moderado a severo con la ventaja de tener menos efectos adversos típicos de opioides tales como predisposicion al abuso, tolerancia, constipacion y depresion respiratoria.Pharmaceutical compositions containing two active substances, one of them being an opioid analgesic known as tramadol or one of its enantiomers or one of its pharmaceutically acceptable salts and the other a non-steroidal anti-inflammatory analgesic known as lysine clonixinate. When both drugs are combined in specific proportions, the combination produces pharmacological effects of analgesia that indicate a superaditivity (synergy), so it is possible to use less of both drugs to achieve the same degree of analgesia as when used alone. By decreasing the amount of each drug in the combination, the side effects associated with each of them are reduced in number and degree, therefore this therapeutic strategy can be a promising tool in the relief of moderate to severe acute pain with the advantage of having less adverse effects typical of opioids such as predisposition to abuse, tolerance, constipation and respiratory depression.

ARP070101074A 2006-03-16 2007-03-16 PHARMACEUTICAL SYNERGISTIC COMPOSITION OF TRAMADOL AND LISINE CLONIXINATE AR057508A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/MX2006/000018 WO2007105929A1 (en) 2006-03-16 2006-03-16 Synergistic pharmaceutical composition of tramadol and lysine clonixinate

Publications (1)

Publication Number Publication Date
AR057508A1 true AR057508A1 (en) 2007-12-05

Family

ID=38509710

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070101074A AR057508A1 (en) 2006-03-16 2007-03-16 PHARMACEUTICAL SYNERGISTIC COMPOSITION OF TRAMADOL AND LISINE CLONIXINATE

Country Status (2)

Country Link
AR (1) AR057508A1 (en)
WO (1) WO2007105929A1 (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU661723B2 (en) * 1991-10-30 1995-08-03 Mcneilab, Inc. Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug

Also Published As

Publication number Publication date
WO2007105929A1 (en) 2007-09-20

Similar Documents

Publication Publication Date Title
WO2001082914A3 (en) Topical anesthetic/opioid formulations and uses thereof
MX2009005339A (en) Modified release analgesic suspensions.
IL194885A0 (en) Pharmaceutical combination comprising 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol and an nsaid
WO2007112274A3 (en) Formulations of low dose non-steroidal anti-inflammatory drugs and beta-cyclodextrin
TW200603787A (en) Topical preparations containing ambroxol
MX2009013574A (en) Modified release solid or semi-solid dosage forms.
DE602007002154D1 (en) Analgesic composition of topically applied, non-steroidal and anti-inflammatory drugs and opioids
AR060836A1 (en) A TRANS-MUCOSA DISK TO ADMINISTER AN ACTIVE AGENT, A TRANS-MUCOSA COMPOSITION AND THE METHOD OF ADMINISTRATION OBTAINED
AR082167A1 (en) GASTRORTENTIVE DOSAGE FORMS
WO2005123192A3 (en) Improving pain treatment with strontium combinations
BRPI0415953B8 (en) controlled release dosage formulation and set of controlled release dosage forms
WO2006050002A3 (en) Compositions for controlled delivery of pharmaceutically active compounds
HK1176318A1 (en) Injection device
WO2005035485A3 (en) Analgesic compounds, their synthesis and pharmaceutical compositions containing them
ECSP099348A (en) PHARMACEUTICAL COMPOSITION OF MODIFIED RELEASE OF A RELAXING MUSCLE AND AN NSAID
DE60219963D1 (en) PHARMACEUTICAL COMPOSITION FOR THE CONTROL OF THE BLOOD SUGAR IN PATIENTS WITH TYPE 2 DIABETES
AR065917A1 (en) PHARMACEUTICAL COMPOSITION IN THE FORM OF A SUBLINGUAL TABLET THAT INCLUDES A NON-STEROID ANTI-INFLAMMATORY AND AN OPIACEAL ANALGESIC FOR PAIN MANAGEMENT
JP2009534367A5 (en)
BRPI0510855A (en) medicament in film form for oral administration and use of pharmaceutically acceptable estriol and / or estriol esters
AR057508A1 (en) PHARMACEUTICAL SYNERGISTIC COMPOSITION OF TRAMADOL AND LISINE CLONIXINATE
ECSP10010442A (en) ORAL GALENIC FORMULATION INCLUDING KETOROLACO AND VITAMINS OF COMPLEX B, IN WHICH VITAMIN B6 IS IN AN EXTERNAL LAYER SEPARATED FROM THE REST OF ACTIVE PRINCIPLES
PE20160038A1 (en) SYNERGISTIC PHARMACEUTICAL COMPOSITION OF TWO ANALGESICS WITH DIFFERENT PHARMACOKINETIC PROFILE
AR055807A1 (en) SYNERGISTIC PHARMACEUTICAL COMPOSITION OF DICHLOFENACO AND LISINE CLONIXINATE
AR060205A1 (en) SYNERGISTIC PHARMACEUTICAL COMPOSITION OF CARISOPRODOL AND LISINE CLONIXINATE
BR112021016795A8 (en) ADMINISTRATION OF JUICE ACTIVATING ENZYME INHIBITOR AND CHECKPOINT INHIBITORS

Legal Events

Date Code Title Description
FB Suspension of granting procedure