AR057234A1 - Uso de eif-5a para destruir celulas de meiloma multiple - Google Patents

Uso de eif-5a para destruir celulas de meiloma multiple

Info

Publication number
AR057234A1
AR057234A1 ARP060105502A ARP060105502A AR057234A1 AR 057234 A1 AR057234 A1 AR 057234A1 AR P060105502 A ARP060105502 A AR P060105502A AR P060105502 A ARP060105502 A AR P060105502A AR 057234 A1 AR057234 A1 AR 057234A1
Authority
AR
Argentina
Prior art keywords
eif
cells
meiloma
destroy multiple
destroy
Prior art date
Application number
ARP060105502A
Other languages
English (en)
Inventor
John E Thompson
Catherine Taylor
Original Assignee
Senesco Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senesco Technologies Inc filed Critical Senesco Technologies Inc
Publication of AR057234A1 publication Critical patent/AR057234A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0033—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being non-polymeric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente se relaciona con el factor de iniciacion eucariotica 5A y con el uso de polinucleotidos que lo codifican para inhibir el crecimiento de células de cáncer e inhibir metástasis. En una realizacion preferida, el eIF-5A1 se utiliza para destruir células de mieloma multiple.
ARP060105502A 2005-12-13 2006-12-13 Uso de eif-5a para destruir celulas de meiloma multiple AR057234A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74960405P 2005-12-13 2005-12-13
US79516806P 2006-04-27 2006-04-27

Publications (1)

Publication Number Publication Date
AR057234A1 true AR057234A1 (es) 2007-11-21

Family

ID=38163623

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060105502A AR057234A1 (es) 2005-12-13 2006-12-13 Uso de eif-5a para destruir celulas de meiloma multiple

Country Status (11)

Country Link
US (1) US20070154457A1 (es)
EP (1) EP1973562A2 (es)
JP (2) JP2009519351A (es)
KR (2) KR20080075552A (es)
AR (1) AR057234A1 (es)
AU (1) AU2006325752B2 (es)
CA (1) CA2633043A1 (es)
IL (1) IL192064A0 (es)
NZ (1) NZ569075A (es)
TW (1) TWI441651B (es)
WO (1) WO2007070824A2 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007109674A2 (en) * 2006-03-20 2007-09-27 Senesco Technologies, Inc. Use of eif-5a1 sirna and antisense to treat sepsis or haemorrhagic shock
JP2011516035A (ja) * 2008-02-21 2011-05-26 セネスコ テクノロジーズ，インコーポレイティド 所望のポリヌクレオチドの発現を達成するためのセンス構築物の使用と組合わせた内因的遺伝子のダウンレギュレーションを達成するためのｓｉＲＮＡの使用
US8703929B2 (en) * 2008-03-07 2014-04-22 Senesco Technologies, Inc. Compositions comprising siRNA and plasmids
JP2012501650A (ja) * 2008-09-03 2012-01-26 セネスコ テクノロジーズ，インコーポレイティド 癌細胞にアポトーシスを誘導するための切断型ｅｉｆ−５ａ１ポリヌクレオチドの使用
WO2018024608A2 (en) * 2016-08-03 2018-02-08 Cbmed Gmbh Center For Biomarker Research In Medicine Antitumor compounds and tumor diagnosis

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1002079A2 (en) * 1997-06-30 2000-05-24 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Novel inhibitor of cellular proliferation
US7381708B2 (en) * 2001-07-23 2008-06-03 Sensco Technologies, Inc. Suppression of eIF5A1 expression by the use of antisense oligonucleotides for the prevention of retinal cell death in the glaucomatous eye
US7166467B2 (en) * 2001-07-23 2007-01-23 Senesco Technologies, Inc. Nucleic acids, polypeptides, compositions, and methods for modulating apoptosis
US7968523B2 (en) * 2001-07-23 2011-06-28 Senesco Technologies, Inc. Method for inducing apoptosis using apoptosis-specific EIF5-A
US7261875B2 (en) * 2001-12-21 2007-08-28 Board Of Regents, The University Of Texas System Dendritic poly (amino acid) carriers and methods of use
JP4754819B2 (ja) * 2002-05-07 2011-08-24 セネスコ テクノロジーズ，インコーポレイティド アポトーシス調節に関する核酸、ポリペプチド及び方法
JP2006520611A (ja) * 2003-03-05 2006-09-14 セネスコ テクノロジーズ，インコーポレイティド ｅＩＦ−５Ａ１の発現を抑制するための、アンチセンス・オリゴヌクレオチド又はｓｉＲＮＡの使用
TW200512293A (en) * 2003-06-06 2005-04-01 Senesco Technologies Inc Inhibition of apoptosis-specific eIF-5A ("eIF-5A1") with antisense oligonucleotides and siRNAs as anti-inflammatory therapeutics
US8703929B2 (en) * 2008-03-07 2014-04-22 Senesco Technologies, Inc. Compositions comprising siRNA and plasmids
US8445638B2 (en) * 2008-09-03 2013-05-21 Senesco Technologies, Inc. Use of a truncated eIF-5A1 polynucleotide to induce apoptosis in cancer cells

Also Published As

Publication number Publication date
NZ569075A (en) 2011-12-22
KR20140098870A (ko) 2014-08-08
AU2006325752B2 (en) 2013-03-14
CA2633043A1 (en) 2007-06-21
EP1973562A2 (en) 2008-10-01
TWI441651B (zh) 2014-06-21
WO2007070824A3 (en) 2007-12-13
US20070154457A1 (en) 2007-07-05
WO2007070824A2 (en) 2007-06-21
JP2009519351A (ja) 2009-05-14
KR20080075552A (ko) 2008-08-18
IL192064A0 (en) 2009-02-11
AU2006325752A1 (en) 2007-06-21
JP2013173753A (ja) 2013-09-05
TW200800274A (en) 2008-01-01

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