AR056310A1 - Derivados de purina, procedimiento de obtencion, composiciones farmaceuticas y usos - Google Patents
Derivados de purina, procedimiento de obtencion, composiciones farmaceuticas y usosInfo
- Publication number
- AR056310A1 AR056310A1 ARP060101440A ARP060101440A AR056310A1 AR 056310 A1 AR056310 A1 AR 056310A1 AR P060101440 A ARP060101440 A AR P060101440A AR P060101440 A ARP060101440 A AR P060101440A AR 056310 A1 AR056310 A1 AR 056310A1
- Authority
- AR
- Argentina
- Prior art keywords
- atoms
- nhet
- hal
- mnr5r6
- ncyc
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Los compuestos de la formula I en donde X es OH o NH2, R1 es H o A, R2, R3 son en cada caso, de modo independiente entre sí, H, A, Hal, OH, OA o CN, R4 es Ar o Het1, R5, R6 son en cada caso, de modo independiente entre sí, H o A, A es fenilo, que no está sustituido o que puede estar mono-, di- o trisustituido con Hal, A, OA, OH, alquenilo con 2 a 6 átomos de C, alquinilo con 2 a 6 átomos de C, NO2, NR5R6, CONR5R6, COOH, COOA, CN, CHO, COA, fenilo, (CH2) nHet, O(CH2) nHet, NH(CH2) nHet, O(CH2)nCyc, NH(CH2)nCyc, O(CH2)mNR5R6, NR1(CH2)mNR5R6 y/u O(CH2)mNR1 (CH2)mOR1, Het1 es un heterociclo aromático mono- o bibíclico con 1 a 4 átomos de N, O Y/o S, que no está sustituido o que puede estar mono-, di- o trisustituido con Hal, A, OA, OH, alquenilo con 2 a 6 átomos de C, alquinilo con 2 a 6 átomos de C, NO2, NR5R6, CONR5R6, COOH, COOA, CN, CHO, COA, fenilo, (CH2)nHet, O(CH2)nHet, O(CH2)nCyc, NH(CH2)nCyc, O(CH2)mNR5r6, NR1(CH2)mNR5R6 y/u O(CH2)mNR1(CH2)mOR1, Het es un heterociclo mono- o bicíclico saturado, insaturado o aromático con 1 a 4 átomos de N, O y/o S, que puede no estar sustituido o que puede estar mono-, di- o trisustituido con Hal, A, OA, fenilo, COOA, CN y/u oxígeno del carbonilo (=O), A es alquilo con 1 a 10 átomos de C, en donde también 1-7 átomos de H pueden estar reemplazados por F y/o cloro, Cyc es cicloalquilo con 3 a 7 átomos de C, Hal es F, Cl, Br o I, n es 0, 1, 2, 3 o 4, m es 1, 2, 3 o 4, así como sus derivados, solvatos, sales, tautomeros y estereoisomeros de utilidad farmacéutica, incluyendo sus mezclas en todas las proporciones. Son inhibidores de las tirosina quinasas, en especial de la TIE-2, y de las Raf-quinasas, y pueden utilizarse, p.ej., para el tratamiento de tumores. Proceso de preparacion de dichos compuestos y composiciones farmacéuticas que los comprenden.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005017259A DE102005017259A1 (de) | 2005-04-14 | 2005-04-14 | Purinderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR056310A1 true AR056310A1 (es) | 2007-10-03 |
Family
ID=36579893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060101440A AR056310A1 (es) | 2005-04-14 | 2006-04-12 | Derivados de purina, procedimiento de obtencion, composiciones farmaceuticas y usos |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20080214582A1 (es) |
| EP (1) | EP1869047A1 (es) |
| JP (1) | JP2008535874A (es) |
| AR (1) | AR056310A1 (es) |
| AU (1) | AU2006233530A1 (es) |
| CA (1) | CA2604294A1 (es) |
| DE (1) | DE102005017259A1 (es) |
| WO (1) | WO2006108482A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120189641A1 (en) | 2009-02-25 | 2012-07-26 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
| WO2010099138A2 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| WO2010099363A1 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| EP2401613A2 (en) | 2009-02-27 | 2012-01-04 | OSI Pharmaceuticals, LLC | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| JP2014519813A (ja) | 2011-04-25 | 2014-08-21 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 癌薬剤発見、診断、および治療におけるｅｍｔ遺伝子シグネチャーの使用 |
| AU2012341028C1 (en) * | 2011-09-02 | 2017-10-19 | Mount Sinai School Of Medicine | Substituted pyrazolo[3,4-D]pyrimidines and uses thereof |
| US9408885B2 (en) | 2011-12-01 | 2016-08-09 | Vib Vzw | Combinations of therapeutic agents for treating melanoma |
| WO2013152252A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
| US20170273922A1 (en) * | 2014-10-03 | 2017-09-28 | The Royal Institution For The Advacement Of Learning/Mcgill University | Urea and bis-urea based compounds and analogues thereof useful in the treatment of androgen receptor mediated diseases or disorders |
| EP3579872A1 (en) | 2017-02-10 | 2019-12-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the mapk pathway |
| WO2019133810A1 (en) | 2017-12-28 | 2019-07-04 | Tract Pharmaceuticals, Inc. | Stem cell culture systems for columnar epithelial stem cells, and uses related thereto |
| CN115710281B (zh) * | 2022-11-14 | 2024-05-17 | 南京中医药大学 | 一种异噁唑并[5,4-b]吡啶类FLT3抑制剂及其制备方法与用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2462441A1 (en) * | 2001-10-18 | 2003-04-24 | Pier F. Cirillo | 1,4-disubstituted benzo-fused urea compounds as cytokine inhibitors |
| US20030199525A1 (en) * | 2002-03-21 | 2003-10-23 | Hirst Gavin C. | Kinase inhibitors |
| SG145748A1 (en) * | 2003-08-15 | 2008-09-29 | Irm Llc | 6-substituted anilino purines as rtk inhibitors |
| TW200530236A (en) * | 2004-02-23 | 2005-09-16 | Chugai Pharmaceutical Co Ltd | Heteroaryl phenylurea |
-
2005
- 2005-04-14 DE DE102005017259A patent/DE102005017259A1/de not_active Withdrawn
-
2006
- 2006-03-15 EP EP06723450A patent/EP1869047A1/de not_active Withdrawn
- 2006-03-15 US US11/910,776 patent/US20080214582A1/en not_active Abandoned
- 2006-03-15 CA CA002604294A patent/CA2604294A1/en not_active Abandoned
- 2006-03-15 AU AU2006233530A patent/AU2006233530A1/en not_active Abandoned
- 2006-03-15 WO PCT/EP2006/002380 patent/WO2006108482A1/de active Application Filing
- 2006-03-15 JP JP2008505752A patent/JP2008535874A/ja active Pending
- 2006-04-12 AR ARP060101440A patent/AR056310A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2006233530A1 (en) | 2006-10-19 |
| US20080214582A1 (en) | 2008-09-04 |
| EP1869047A1 (de) | 2007-12-26 |
| CA2604294A1 (en) | 2006-10-19 |
| WO2006108482A1 (de) | 2006-10-19 |
| DE102005017259A1 (de) | 2006-10-19 |
| JP2008535874A (ja) | 2008-09-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |