AR055624A1 - CHEMICAL SUBSTANCE SELECTED BETWEEN HETEROARIL - SUBSTITUTED NITRILS, ITS USE TO PREPARE A MEDICINAL PRODUCT, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE IT AND PROCESSES TO PREPARE SUCH SUBSTANCES - Google Patents
CHEMICAL SUBSTANCE SELECTED BETWEEN HETEROARIL - SUBSTITUTED NITRILS, ITS USE TO PREPARE A MEDICINAL PRODUCT, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE IT AND PROCESSES TO PREPARE SUCH SUBSTANCESInfo
- Publication number
- AR055624A1 AR055624A1 ARP060103810A ARP060103810A AR055624A1 AR 055624 A1 AR055624 A1 AR 055624A1 AR P060103810 A ARP060103810 A AR P060103810A AR P060103810 A ARP060103810 A AR P060103810A AR 055624 A1 AR055624 A1 AR 055624A1
- Authority
- AR
- Argentina
- Prior art keywords
- prepare
- phenyl
- alkyl
- substituted
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A61P33/12—Schistosomicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Sustancia química seleccionada entre compuestos de heteroaril-nitrilos sustituidos de formula (1) en donde: R4 representa halogeno; R2 representa -fenil-alquilen C1-3-X, -piridil-fenil-alquilen C1-3-X o -fenil-alquilen C1-3-X-RJ, en donde fenilo está opcionalmente sustituido con un grupo seleccionado de halogeno o CF3, RJ representa Z, -alquilen C1-3-Z -C(O)Z; X y Z representan, de modo independiente, un grupo hidrocarbonado saturado monocíclico de 6 miembros que contiene uno o dos átomos de N y opcionalmente un átomo de O, que está opcionalmente sustituido con un grupo seleccionado de: alquilo C1-4, alquil C1-4-OH, OH y NRERF; RE y RF independientemente representan H o alquilo C1-4; y sus derivados farmacéuticamente aceptables. Su uso para preparar un medicamento util como inhibidor de cisteína proteasa y tratamiento de la malaria, composiciones farmacéuticas que comprenden estos compuestos y procedimientos para su reparacion.Chemical substance selected from substituted heteroaryl nitrile compounds of formula (1) wherein: R4 represents halogen; R2 represents -phenyl-C1-3-X alkylene, -pyridyl-phenyl-C1-3-X alkylene or -phenyl-C1-3-X-RJ alkylene, wherein phenyl is optionally substituted with a group selected from halogen or CF3 , RJ represents Z, -C 1-3 alkyl-Z-C (O) Z; X and Z independently represent a 6-membered monocyclic saturated hydrocarbon group containing one or two N atoms and optionally an O atom, which is optionally substituted with a group selected from: C1-4 alkyl, C1- alkyl 4-OH, OH and NRERF; RE and RF independently represent H or C1-4 alkyl; and its pharmaceutically acceptable derivatives. Its use to prepare a drug useful as a cysteine protease inhibitor and treatment of malaria, pharmaceutical compositions comprising these compounds and procedures for their repair.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05381043 | 2005-09-02 | ||
| EP06110666 | 2006-03-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR055624A1 true AR055624A1 (en) | 2007-08-29 |
Family
ID=37770277
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060103810A AR055624A1 (en) | 2005-09-02 | 2006-08-31 | CHEMICAL SUBSTANCE SELECTED BETWEEN HETEROARIL - SUBSTITUTED NITRILS, ITS USE TO PREPARE A MEDICINAL PRODUCT, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE IT AND PROCESSES TO PREPARE SUCH SUBSTANCES |
| ARP060103809A AR057110A1 (en) | 2005-09-02 | 2006-08-31 | DERIVATIVES OF HETEROARIL-NITRILOS REPLACED WHICH ARE INHIBITORS OF PROTEASES |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060103809A AR057110A1 (en) | 2005-09-02 | 2006-08-31 | DERIVATIVES OF HETEROARIL-NITRILOS REPLACED WHICH ARE INHIBITORS OF PROTEASES |
Country Status (4)
| Country | Link |
|---|---|
| AR (2) | AR055624A1 (en) |
| PE (2) | PE20070612A1 (en) |
| TW (2) | TW200804351A (en) |
| WO (3) | WO2007025774A2 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2030621A1 (en) * | 2007-08-21 | 2009-03-04 | Glaxo Group Limited | Novel substituted pyrimidines as cysteine protease inhibitors |
| EP2077841A1 (en) * | 2006-10-30 | 2009-07-15 | Glaxo Group Limited | Novel substituted pyrimidines as cysteine protease inhibitors |
| KR20100023948A (en) | 2007-06-08 | 2010-03-04 | 닛뽕 케미파 가부시키가이샤 | Therapeutic or prophylactic agent for cerebral aneurysm |
| WO2009054454A1 (en) | 2007-10-24 | 2009-04-30 | National University Corporation Tokyo Medical And Dental University | Regulator for signaling of toll-like receptor, which comprises cathepsin inhibitor as active ingredient |
| DE102008063561A1 (en) * | 2008-12-18 | 2010-08-19 | Bayer Cropscience Ag | Hydrazides, process for their preparation and their use as herbicides and insecticides |
| CN102267964B (en) * | 2011-06-15 | 2014-06-18 | 浙江师范大学 | 3-hydroxy-2,3-dihydro-benzofuran derivatives as well as synthesis method and application thereof |
| EP3778576B1 (en) | 2018-03-28 | 2024-04-17 | Hanlim Pharmaceutical Co., Ltd. | 2-cyanopyrimidin-4-yl carbamate or urea derivative or salt thereof, and pharmaceutical composition including same |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR036375A1 (en) * | 2001-08-30 | 2004-09-01 | Novartis Ag | PIRROLO [2,3-D] PIRIMIDINE -2- CARBONITRILE COMPOUNDS, A PROCESS FOR THEIR PREPARATION, A PHARMACEUTICAL COMPOSITION AND THE USE OF SUCH COMPOUNDS FOR THE PREPARATION OF MEDICINES |
-
2006
- 2006-08-31 AR ARP060103810A patent/AR055624A1/en not_active Application Discontinuation
- 2006-08-31 PE PE2006001057A patent/PE20070612A1/en not_active Application Discontinuation
- 2006-08-31 WO PCT/EP2006/008578 patent/WO2007025774A2/en active Application Filing
- 2006-08-31 PE PE2006001056A patent/PE20070332A1/en not_active Application Discontinuation
- 2006-08-31 WO PCT/EP2006/008579 patent/WO2007025775A2/en active Application Filing
- 2006-08-31 WO PCT/EP2006/008580 patent/WO2007025776A2/en active Application Filing
- 2006-08-31 AR ARP060103809A patent/AR057110A1/en not_active Application Discontinuation
- 2006-08-31 TW TW095132087A patent/TW200804351A/en unknown
- 2006-08-31 TW TW095132088A patent/TW200804352A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PE20070332A1 (en) | 2007-05-11 |
| TW200804352A (en) | 2008-01-16 |
| WO2007025775A2 (en) | 2007-03-08 |
| PE20070612A1 (en) | 2007-06-23 |
| WO2007025776A2 (en) | 2007-03-08 |
| WO2007025774A2 (en) | 2007-03-08 |
| WO2007025774A3 (en) | 2007-04-26 |
| WO2007025776A3 (en) | 2007-05-03 |
| TW200804351A (en) | 2008-01-16 |
| AR057110A1 (en) | 2007-11-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |