AR054865A1 - METAL COMPLEXES WITH CONTENT OF PERFLUOROALQUILO, PROCEDURES FOR THEIR PREPARATION, AS WELL AS ITS USE - Google Patents

Abstract

Claim 1: Complexes with perfluoroalkyl content with a linker structure with nitrogen of the general formula (1), wherein: R represents a mono- or oligosaccharide radical linked through 1-OH, in this case Q has the meaning of a selected group of. delta-CO- (CH2) n '' - epsilon; delta-NH- (CH2) n '' - epsilon; delta- (CH2) m-epsilon; where n '' is an integer of 1 and 5, and m is an integer of 1 and 6; and where delta indicates the binding site with the linker L and epsilon indicates the binding site with the radical R; or R has one of the following meanings, then Q has the meaning of a direct bond: R means a polar radical selected from: the complexes K of the general formulas (2) to V, where R1 here means a hydrogen atom or a metal ion equivalent of the atomic numbers 20-29, 31-33, 37-39, 42-44, 49 or 57-83, and the radicals R2, R3, R4, U and U1 represent the meaning indicated below; or a carbon chain with C1-30 attached to linker L through -CO-, -NR7- or a direct link; which can be linear or branched, saturated or unsaturated, and which is optionally interrupted by 1-10 oxygen atoms, 1-5 -NHCO groups, 1-5 -CONH, 1-2 sulfur atoms, 1-5 -NH groups or 1-2 phenylene groups, which may be optionally substituted with 1-2 -OH groups, 1-2 -NH2 groups, 1-2 -COOH groups or 1-2 -SO3H groups; and which is optionally substituted with 1-10 -OH groups, 1-5 -COOH groups, 1-2 SO3H groups, 1- 5 -NH2 groups, C1-4 alkoxy groups; wherein R7 is H or C1-4 alkyl; Rf is a perfluorinated, linear or branched carbon chain, with the formula -CnF2nE, in which E represents a fluorine, chlorine, bromine, iodine or terminal hydrogen atom and n are numbers 4-30; K is a metal complex of the general formula (2), wherein R1 is a hydrogen atom or a metal ion equivalent of the atomic numbers 21-29, 31-33, 37-39, 42-44, 49 or 57 -83, with the proviso that at least two R1s are equivalent to metal ions; R2 and R3 independently represent each other, hydrogen, C1-7 alkyl, benzyl, phenyl, -CH2OH or -CH2OCH3; and U represents -C6H4-O-CH2-omega-, - (CH2) 1-5-omega, a phenylene group, -CH2-NHCO-CH2-CH (CH2COOH) -C6H4- omega-, -C6H4- (OCH2CH2) 0-1-N (CH2COOH) -CH2-omega or a C1-12 alkylene group or - (CH2) 7-12-C6H4-O- optionally interrupted by one or more oxygen atoms, 1 to 3 -NHCO- groups, 1 to 3 groups -CONH and / or substituted with 1 to 3 groups - (CH2) 0-5COOH, where omega is the site of union with -CO-; or of the general formula (3), wherein R1 has the meaning indicated above, R4 represents hydrogen or a metal ion equivalent mentioned in R1 and U1 represents -C6H4-O-CH2-omega- or a group - (CH2) p'-, where omega is the site of union with -CO- and p 'is an integer between 1 and 4; or of the general formula (4), wherein R1 and R2 have the meaning mentioned above; or of the general formula (5) or (6), where R1 has the meaning indicated above, or of the general formula (7), where R1 has the meaning indicated above, or of the general formula (8) , where R1 and U1 have the aforementioned meaning where omega is the site of union with -CO- or of the general formula (9), where R1 has the meaning indicated above, and U2 represents a C1 alkylene group -20 straight or branched chain, saturated or unsaturated, which optionally contains imino, phenylene, phenyloxy, phenyleneimino, amide, hydrazide, carbonyl, ester, oxygen atoms, sulfur and / or oxygen groups, optionally substituted by hydroxy, mercapto groups, oxo, thioxo, carboxy, carboxy alkyl, ester and / or amino, and in the radical K there may be optionally existing acid groups, optionally as salts of bases or amino acids or amides of organic and / or inorganic amino acids; and L represents a radical selected from the following radicals of formulas (10) to (12), where n 'and m' represent, independently of each other, an integer between 0 and 4, and m '+ n' greater than or equal to 1, and R8 and R8 'are, independently of each other, either -H or -OH, where in the case of m' + n '> 1, each group - (CR8R8') - can be the same or different ; and W is a direct bond, -O- or a phenylene group, which may be optionally substituted with 1 to 4 hydroxy groups, and q 'is 1, 2, 3 or 4; where alpha is the site of union of L with the complex K, beta is the site of union of L with the radical Q and gamma represents the site of union of L with the radical X; and X is a group of the formula (13), wherein Y is a direct link, a group -CO- or an NR6 group; wherein R6 is -H or a linear or branched, saturated or unsaturated C1-15 carbon chain that may be interrupted by 1-4 O atoms, 1-3 -NHCO groups, 1-3 -CONH groups, 1-2 -SO2 groups, 1.2 sulfur atoms, 1-3 -NH groups or 1-2 phenylene groups, which may be optionally substituted with 1-2 OH groups, 1.2 NH2 groups, 1-2 -COOH groups or 1 -2 groups -SO3H; and which is optionally substituted with 1-10 OH groups, 1-5 -COOH groups, 1-2 -SO3H groups, 1-5 NH2 groups, 1.5 C1-4 alkoxy groups; and G is -O- or -SO2-; s and s' are, independently of each other, 1 or 2, t is 0 or 1; and (rho) represents the site of union of X with L and (xi) represents the site of union of X with Rf.