AR054852A1 - PROCESSES TO PREPARE DERIVATIVES OF PIRAZOL 0- GLUCOSIDE AND NEW INTERMEDIARIES OF SUCH PROCESSES - Google Patents
PROCESSES TO PREPARE DERIVATIVES OF PIRAZOL 0- GLUCOSIDE AND NEW INTERMEDIARIES OF SUCH PROCESSESInfo
- Publication number
- AR054852A1 AR054852A1 ARP060103114A ARP060103114A AR054852A1 AR 054852 A1 AR054852 A1 AR 054852A1 AR P060103114 A ARP060103114 A AR P060103114A AR P060103114 A ARP060103114 A AR P060103114A AR 054852 A1 AR054852 A1 AR 054852A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- designates
- processes
- cycloalkyl
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Además, se refiere a pocesos para preparar eductos e intermediarios en los procesos anteriores y a los intermediarios como tales. Reivindicacion 1: Proceso para preparar compuestos de la formula general 19 en donde: R1 designa alquilo C1-4, un grupo alquilo C1-4 sustituido con uno o varios átomos de F, o cicloalquilo C3-6, y R2 designa alquilo C1-4, un grupo alquilo C1-4 sustituido con uno o varios átomos de F, o cicloalquilo C3-6; y R3 designa F, Cl, Br, alquilo C1-4, cicloalquilo C3-6, alcoxi C1-4 o cicloalquil C3-6-oxi; yR4, R5 designan, de modo independiente entre sí, H, F, Cl, Br, alquilo C1-4 o alcoxi C1-4; y R6, R7a, R7b, R7c tienen, de modo independiente entre sí, un significado seleccionado delgrupo H, (alquil C1- 6)carbonilo, fenilcarbonilo y fenil-(alquil C1-3)-carbonilo; incluyendo sus tautomeros, estereoisomeros, mezclas y sales; caracterizado porque la aglicona de la formula (3) en donde R1 a R5 se definen como se hizo con anteioridad en la presente; se obtiene por una hidrogenacion catalítica de un compuesto de la formula (4) en dodne R1 a R5 se definen como se hizo con anterioridad en la rpesente, y Qes Cl, BR, I, alcoxi C1-4, alquil C1-4-tio, feniltio, cicloalquil C3-6-oxi, alquil C1-4- carboniloxi, -NRaRb, en donde Ra, Rb designan, de modo independiente entre sí, alquilo C1-4, o -NRaRb designa pirrolidinilo, piperidinilo, morfolinilo, piperazinilo o N-alquil C1-4-piperazinilo; en un solvente o una mezcla de solventes.In addition, it refers to wells to prepare educates and intermediaries in the above processes and to intermediaries as such. Claim 1: Process for preparing compounds of the general formula 19 wherein: R1 designates C1-4 alkyl, a C1-4 alkyl group substituted with one or more F atoms, or C3-6 cycloalkyl, and R2 designates C1-4 alkyl , a C1-4 alkyl group substituted with one or more F atoms, or C3-6 cycloalkyl; and R 3 designates F, Cl, Br, C 1-4 alkyl, C 3-6 cycloalkyl, C 1-4 alkoxy or C 3-6 cycloalkyl; and R4, R5 designate, independently of one another, H, F, Cl, Br, C1-4 alkyl or C1-4 alkoxy; and R6, R7a, R7b, R7c have, independently of one another, a meaning selected from the group H, (C1-6 alkyl) carbonyl, phenylcarbonyl and phenyl- (C1-3 alkyl) -carbonyl; including its tautomers, stereoisomers, mixtures and salts; characterized in that the aglycone of the formula (3) wherein R1 to R5 are defined as was done hereinbefore; it is obtained by a catalytic hydrogenation of a compound of the formula (4) in dodne R1 to R5 are defined as previously done, and Qes Cl, BR, I, C1-4 alkoxy, C1-4 alkyl , phenylthio, C3-6-oxycycloalkyl, C1-4alkylcarbonyloxy, -NRaRb, wherein Ra, Rb designates, independently of one another, C1-4 alkyl, or -NRaRb designates pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl or N-C 1-4 alkyl piperazinyl; in a solvent or a mixture of solvents.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05015935 | 2005-07-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR054852A1 true AR054852A1 (en) | 2007-07-18 |
Family
ID=37102155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060103114A AR054852A1 (en) | 2005-07-22 | 2006-07-20 | PROCESSES TO PREPARE DERIVATIVES OF PIRAZOL 0- GLUCOSIDE AND NEW INTERMEDIARIES OF SUCH PROCESSES |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1910391A1 (en) |
| JP (2) | JP4888840B2 (en) |
| KR (1) | KR20080036112A (en) |
| CN (1) | CN101218244A (en) |
| AR (1) | AR054852A1 (en) |
| AU (1) | AU2006271653A1 (en) |
| BR (1) | BRPI0613690A2 (en) |
| CA (1) | CA2621269A1 (en) |
| IL (1) | IL188898A0 (en) |
| MX (1) | MX2008000011A (en) |
| RU (1) | RU2008106461A (en) |
| TW (1) | TW200728286A (en) |
| WO (1) | WO2007010015A1 (en) |
| ZA (1) | ZA200709951B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004031203A1 (en) * | 2002-10-04 | 2004-04-15 | Kissei Pharmaceutical Co., Ltd. | Pyrazole derivative, medicinal composition containing the same, medicinal use thereof and intermediate in producing the same |
| US7375090B2 (en) | 2003-08-26 | 2008-05-20 | Boehringer Ingelheim International Gmbh | Glucopyranosyloxy-pyrazoles, pharmaceutical compositions containing these compounds, the use thereof and processed for the preparation thereof |
| UY29694A1 (en) * | 2005-07-28 | 2007-02-28 | Boehringer Ingelheim Int | METHODS TO PREVENT AND TREAT METABOLIC AND NEW DISORDERS DERIVED FROM PIRAZOL-O-GLUCOSIDO |
| UY30082A1 (en) | 2006-01-11 | 2007-08-31 | Boehringer Ingelheim Int | CRYSTAL FORM OF 1- (1-METHYLETHYL) -4` - ((2-FLUORO-4-METOXIFENIL) METHYL) -5`- METHYL-1H-PIRAZOL-3`-OBD-GLUCOPYRANOSIDE, A METHOD FOR PREPARATION AND USE OF THE SAME TO PREPARE MEDICATIONS |
| WO2012133783A1 (en) * | 2011-03-31 | 2012-10-04 | キッセイ薬品工業株式会社 | Method for producing benzylpyrazole derivative and production intermediate thereof |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55157504A (en) * | 1979-05-24 | 1980-12-08 | Sankyo Co Ltd | Herbicide |
| WO2002036602A1 (en) * | 2000-11-02 | 2002-05-10 | Ajinomoto Co., Inc. | Novel pyrazole derivatives and diabetes remedies containing the same |
| CZ305971B6 (en) * | 2000-12-28 | 2016-06-01 | Kissei Pharmaceutical Co., Ltd. | Glucopyranosyloxypyrazole derivatives and use thereof in medicaments |
| CA2438593C (en) * | 2001-02-26 | 2010-09-21 | Kissei Pharmaceutical Co., Ltd. | Glucopyranosyloxypyrazole derivatives and medicinal use thereof |
| WO2002068440A1 (en) * | 2001-02-27 | 2002-09-06 | Kissei Pharmaceutical Co., Ltd. | Glycopyranosyloxypyrazole derivatives and medicinal use thereof |
| JP4292570B2 (en) * | 2001-04-27 | 2009-07-08 | 味の素株式会社 | N-substituted pyrazole-O-glycoside derivatives and therapeutic agents for diabetes containing them |
| CA2448741C (en) * | 2001-05-30 | 2010-06-22 | Kissei Pharmaceutical Co., Ltd. | Glucopyranosyloxypyrazole derivative, medicinal composition containing the same, medicinal use thereof, and intermediate therefor |
| US20030087843A1 (en) * | 2001-09-05 | 2003-05-08 | Washburn William N. | O-pyrazole glucoside SGLT2 inhibitors and method of use |
| EP1500403A4 (en) * | 2002-04-26 | 2008-09-17 | Ajinomoto Kk | Preventive/remedy for diabetes |
| PL213095B1 (en) * | 2002-08-08 | 2013-01-31 | Kissei Pharmaceutical | Pyrazole derivative, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof |
| JP2004137245A (en) * | 2002-08-23 | 2004-05-13 | Kissei Pharmaceut Co Ltd | Pyrazole derivative, pharmaceutical composition containing the same, its pharmaceutical use and production intermediate |
| JP4606876B2 (en) * | 2002-08-27 | 2011-01-05 | キッセイ薬品工業株式会社 | Pyrazole derivative, pharmaceutical composition containing the same, and pharmaceutical use thereof |
| WO2004031203A1 (en) * | 2002-10-04 | 2004-04-15 | Kissei Pharmaceutical Co., Ltd. | Pyrazole derivative, medicinal composition containing the same, medicinal use thereof and intermediate in producing the same |
| JPWO2004089967A1 (en) * | 2003-04-01 | 2006-07-06 | 大正製薬株式会社 | Heteroaryl 5-thio-β-D-glucopyranoside derivatives and therapeutic agents for diabetes containing the same |
| CA2529878C (en) * | 2003-06-20 | 2012-11-20 | Kissei Pharmaceutical Co., Ltd. | Pyrazole derivative, drug composition containing the same and production intermediate therefor |
| UY29694A1 (en) * | 2005-07-28 | 2007-02-28 | Boehringer Ingelheim Int | METHODS TO PREVENT AND TREAT METABOLIC AND NEW DISORDERS DERIVED FROM PIRAZOL-O-GLUCOSIDO |
-
2006
- 2006-07-20 EP EP06777849A patent/EP1910391A1/en not_active Withdrawn
- 2006-07-20 MX MX2008000011A patent/MX2008000011A/en not_active Application Discontinuation
- 2006-07-20 AU AU2006271653A patent/AU2006271653A1/en not_active Abandoned
- 2006-07-20 CN CNA2006800246999A patent/CN101218244A/en active Pending
- 2006-07-20 RU RU2008106461/04A patent/RU2008106461A/en not_active Application Discontinuation
- 2006-07-20 CA CA002621269A patent/CA2621269A1/en not_active Abandoned
- 2006-07-20 BR BRPI0613690-7A patent/BRPI0613690A2/en not_active IP Right Cessation
- 2006-07-20 JP JP2008521974A patent/JP4888840B2/en not_active Expired - Fee Related
- 2006-07-20 WO PCT/EP2006/064435 patent/WO2007010015A1/en active Application Filing
- 2006-07-20 KR KR1020087004344A patent/KR20080036112A/en not_active Application Discontinuation
- 2006-07-20 AR ARP060103114A patent/AR054852A1/en unknown
- 2006-07-21 TW TW095126625A patent/TW200728286A/en unknown
-
2007
- 2007-11-19 ZA ZA200709951A patent/ZA200709951B/en unknown
-
2008
- 2008-01-21 IL IL188898A patent/IL188898A0/en unknown
-
2011
- 2011-08-11 JP JP2011176119A patent/JP2012006956A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MX2008000011A (en) | 2008-03-26 |
| CN101218244A (en) | 2008-07-09 |
| EP1910391A1 (en) | 2008-04-16 |
| JP4888840B2 (en) | 2012-02-29 |
| BRPI0613690A2 (en) | 2011-01-25 |
| KR20080036112A (en) | 2008-04-24 |
| JP2012006956A (en) | 2012-01-12 |
| ZA200709951B (en) | 2008-11-26 |
| TW200728286A (en) | 2007-08-01 |
| WO2007010015A1 (en) | 2007-01-25 |
| AU2006271653A1 (en) | 2007-01-25 |
| CA2621269A1 (en) | 2007-01-25 |
| IL188898A0 (en) | 2008-04-13 |
| RU2008106461A (en) | 2009-08-27 |
| JP2009502763A (en) | 2009-01-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |