Se proporcionan métodos para preparar compuestos de oxindol y tio-oxindol, compuestos que son utiles como precursores de compuestos farmacéuticos utiles. Se proporcionan específicamente métodos para preparar compuestos de 5-pirrol-3,3-oxindol y 5-(7- fluoro-3,3-dimetil-2-oxo-2,3-dihidro-1H-indol-5-il)-1-metil-1H-pirrol-2-carbonitrilo. También se proporcionan métodos para preparar compuestos de iminobenzo[b]tiofeno y benzo[b]tiofenona. Reivindicacion 1: Un método para preparar compuestos de oxindol que comprende los pasos de: (a) sustituir un fluoroareno de formula (1) con un nitrilo secundario: donde: X es halogeno; R1, R2, R3 y R4 son, independientemente, seleccionados del grupo formado por H, halogeno, CN, alquilo C1-6, alquilo C1-6 sustituido, alquenilo C2-6, alquenilo C2-6 sustituido, alquinilo C2-6, alquinilo C2-6 sustituido, cicloalquilo C3-8, cicloalquilo C3-8 sustituido, arilo, arilo sustituido, heteroarilo, heteroarilo sustituido, N2+, OSO2CF3, CF3, NO2, SR5, OR5, N(R5)2, COO(R5)2, CON(R5)2 y SO2N(R5)2; o R1 y R2; R2 y R3, R3 y R4, R1, R2, y R3, o R2, R3, y R4 están fusionados para formar: (i) un anillo de 3 a 15 miembros que contiene C saturado o insaturado; o (ii) un anillo heterocíclico de 3 a 15 miembros que contiene en su esqueleto desde 1 a 3 heteroátomos seleccionados del grupo formado por O, S, y NR11; donde (i) o (ii) están opcionalmente sustituidos con alquilo C1-6, alquilo C1-6 sustituido, halogeno, alcoxi C1-6, alcoxi C1-6 sustituido, o N(R5)2; R5 se selecciona del grupo formado por alquilo C1-6 y alquilo C1-6 sustituido; A, D, E y G son, independientemente, seleccionados del grupo formado por C y N, donde si cualquiera de A, D, E o G son N, el correspondiente R1-R4 está opcionalmente ausente; R11 está ausente, es H, alquilo C1-6, alquilo C1-6 sustituido, arilo o arilo sustituido; o una sal farmacéuticamente aceptable de los mismos (b) convertir el sustituyente nitrilo del producto del paso (a) en una amida; y (c) ciclar el producto del paso (b) a dicho oxindol. Reivindicacion 34: Un compuesto seleccionado del grupo formado por 2-(5-bromo-2-fluorofenil)-2-metilpropionitrilo; 2-(3-cloropiridin-2-il)-2-metilpropionitrilo; 2-(3-cloroquinosalin-2-il)-2- metilpropionitrilo; 2-(2-fluorofenil)-2-metilpropionitrilo, 2-(2,3-difluorofenil)-2-metilpropionitrilo, 2-(2,6-difluorofenil)-2-metilpropionitrilo, 2-(2,3-difluorofenil)isobutiramida, 2-(2,6-difluorofenil)isobutiramina, 2-(2- fluorofenil)isobutiramida, y 2-(3-cloropiridin-2-il)isobutiramida, amida de ácido 1-(2,6-difluorofenil)ciclopropancarboxílico; o una sal farmacéuticamente aceptable de los mismos.Methods for preparing oxindole and thio-oxindole compounds are provided, compounds that are useful as precursors of useful pharmaceutical compounds. Methods for preparing compounds of 5-pyrrole-3,3-oxindole and 5- (7- fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indole-5-yl) - are specifically provided - 1-methyl-1H-pyrrole-2-carbonitrile. Methods for preparing iminobenzo [b] thiophene and benzo [b] thiophene compounds are also provided. Claim 1: A method for preparing oxindole compounds comprising the steps of: (a) replacing a fluoroarene of formula (1) with a secondary nitrile: where: X is halogen; R1, R2, R3 and R4 are independently selected from the group consisting of H, halogen, CN, C1-6 alkyl, substituted C1-6 alkyl, C2-6 alkenyl, substituted C2-6 alkenyl, C2-6 alkynyl, alkynyl C2-6 substituted, C3-8 cycloalkyl, C3-8 substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, N2 +, OSO2CF3, CF3, NO2, SR5, OR5, N (R5) 2, COO (R5) 2, CON (R5) 2 and SO2N (R5) 2; or R1 and R2; R2 and R3, R3 and R4, R1, R2, and R3, or R2, R3, and R4 are fused to form: (i) a 3 to 15 member ring containing saturated or unsaturated C; or (ii) a 3 to 15-membered heterocyclic ring containing from its skeleton from 1 to 3 heteroatoms selected from the group consisting of O, S, and NR11; wherein (i) or (ii) are optionally substituted with C1-6 alkyl, substituted C1-6 alkyl, halogen, C1-6 alkoxy, substituted C1-6 alkoxy, or N (R5) 2; R5 is selected from the group consisting of C1-6 alkyl and substituted C1-6 alkyl; A, D, E and G are independently selected from the group consisting of C and N, where if any of A, D, E or G are N, the corresponding R1-R4 is optionally absent; R11 is absent, it is H, C1-6 alkyl, substituted C1-6 alkyl, aryl or substituted aryl; or a pharmaceutically acceptable salt thereof (b) converting the nitrile substituent of the product of step (a) into an amide; and (c) cycling the product of step (b) to said oxindole. Claim 34: A compound selected from the group consisting of 2- (5-bromo-2-fluorophenyl) -2-methylpropionitrile; 2- (3-Chloropyridin-2-yl) -2-methylpropionitrile; 2- (3-Chloroquinosalin-2-yl) -2-methylpropionitrile; 2- (2-fluorophenyl) -2-methylpropionitrile, 2- (2,3-difluorophenyl) -2-methylpropionitrile, 2- (2,6-difluorophenyl) -2-methylpropionitrile, 2- (2,3-difluorophenyl) isobutyramide , 2- (2,6-difluorophenyl) isobutyramine, 2- (2- fluorophenyl) isobutyramide, and 2- (3-chloropyridin-2-yl) isobutyramide, 1- (2,6-difluorophenyl) cyclopropancarboxylic acid amide; or a pharmaceutically acceptable salt thereof.