AR053320A1 - Tienoisoquinolin - fenilsulfonamidas, su uso para la preparacion de medicamentos y composicion farmaceutica - Google Patents

Tienoisoquinolin - fenilsulfonamidas, su uso para la preparacion de medicamentos y composicion farmaceutica

Info

Publication number
AR053320A1
AR053320A1 ARP050105437A ARP050105437A AR053320A1 AR 053320 A1 AR053320 A1 AR 053320A1 AR P050105437 A ARP050105437 A AR P050105437A AR P050105437 A ARP050105437 A AR P050105437A AR 053320 A1 AR053320 A1 AR 053320A1
Authority
AR
Argentina
Prior art keywords
alkyl
aryl
hydrogen
cycloalkenyl
heteroaryl
Prior art date
Application number
ARP050105437A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR053320A1 publication Critical patent/AR053320A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Abstract

Moduladores del receptor de estrogenos. Estos compuestos brindan un medio favorable para tratar el componente inflamatorio de ciertas enfermedades (infarto de miocardio, enfermedad intestinal y artritis. Reivindicacion 1: Un compuesto de formula (1) donde R1 es hidrogeno, alquilo, halogeno, arilo o heteroarilo; R2, R3, R5 y R6 son de modo independiente, hidrogeno, hidroxi, alquilo inferior, alcoxi o halogeno; R4 es alquil; R7 es hidrogeno, -(C=O)r16, -S(O)2N(R18)(R19) o D-glucuronidato; R16 es alquilo, aralquilo o arilo; R17 es alquilo, arilo, heteroarilo, cicloalquilo, alquenilo, cicloalquenilo o alquinilo; y R18 y R19 son de modo independiente, hidrogeno, alquilo, alquenilo, alquinilo, cicloalquilo, monofluoroalquil, perfluoroalquilo, arilo, arilalquilo, cicloalquenilo, heteroarilalquilo, hidroxialquil C2-C6, alcoxialquilo, alquiltioalquilo, carbonilo, acilo, alcoxicarbonilo, -(C(O)NH2, alquilaminocarbonilo, dialquilaminocarbonilo, alquilaminoalquilo o dialquilaminoalquilo; o R18 y R19 se toman junto con el átomo de nitrogeno al que están unidos para formar un anillo carbonado C4-C6 saturado, no saturado o parcialmente saturado.
ARP050105437A 2004-12-21 2005-12-21 Tienoisoquinolin - fenilsulfonamidas, su uso para la preparacion de medicamentos y composicion farmaceutica AR053320A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63820604P 2004-12-21 2004-12-21

Publications (1)

Publication Number Publication Date
AR053320A1 true AR053320A1 (es) 2007-05-02

Family

ID=36602301

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050105437A AR053320A1 (es) 2004-12-21 2005-12-21 Tienoisoquinolin - fenilsulfonamidas, su uso para la preparacion de medicamentos y composicion farmaceutica

Country Status (4)

Country Link
US (1) US7696221B2 (es)
AR (1) AR053320A1 (es)
TW (1) TW200634019A (es)
WO (1) WO2006069182A2 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3380495T1 (sl) 2015-11-24 2022-01-31 Transfert Plus, S.E.C. Peptidne spojine in peptidni konjugati za zdravljenje raka z receptorsko posredovano kemoterapijo
EP3551636A4 (en) * 2016-12-06 2019-12-25 Valorbec, Société en Commandite THIENOISOCHINOLINE AND THEIR DERIVATIVES FOR TREATING CANCER
WO2019095066A1 (en) * 2017-11-15 2019-05-23 Valorbec, Sec Thienoisoquinolines and their derivatives for targeting tubulin, ch-tog, aurora a kinase, tpx2, cdk5rap2 and/or aspm

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0446604A3 (en) * 1990-03-16 1992-02-19 American Cyanamid Company Pyridine and related aza heterocycle derivatives as cardiovascular agents
WO2004009582A1 (en) 2002-07-19 2004-01-29 Pharmacia Corporation Substituted thiophene carboxamide compounds for the treatment of inflammation
JP2006151810A (ja) * 2002-12-26 2006-06-15 Daiichi Asubio Pharma Co Ltd ジヒドロチエノキノリン誘導体及びそれを含む細胞接着阻害剤

Also Published As

Publication number Publication date
WO2006069182A3 (en) 2007-01-04
US20060154875A1 (en) 2006-07-13
US7696221B2 (en) 2010-04-13
TW200634019A (en) 2006-10-01
WO2006069182A2 (en) 2006-06-29

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Legal Events

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FA Abandonment or withdrawal