AR046972A1 - DERIVATIVES OF AMINO-BENCIMIDAZOLS AS INHIBITORS OF THE REPLICATION OF RESPIRATORY SYNCTIAL VIRUSES - Google Patents
DERIVATIVES OF AMINO-BENCIMIDAZOLS AS INHIBITORS OF THE REPLICATION OF RESPIRATORY SYNCTIAL VIRUSESInfo
- Publication number
- AR046972A1 AR046972A1 ARP040104810A AR046972A1 AR 046972 A1 AR046972 A1 AR 046972A1 AR P040104810 A ARP040104810 A AR P040104810A AR 046972 A1 AR046972 A1 AR 046972A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- phenyl
- 4alkyl
- mono
- optionally substituted
- Prior art date
Links
- 230000010076 replication Effects 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000000241 respiratory effect Effects 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- -1 Ar2 Chemical group 0.000 abstract 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- JWYUFVNJZUSCSM-UHFFFAOYSA-N 2-aminobenzimidazole Chemical class C1=CC=C2NC(N)=NC2=C1 JWYUFVNJZUSCSM-UHFFFAOYSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 241000725643 Respiratory syncytial virus Species 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000005054 dihydropyrrolyl group Chemical group [H]C1=C([H])C([H])([H])C([H])([H])N1* 0.000 abstract 1
- 125000005879 dioxolanyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000002184 metal Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000005942 tetrahydropyridyl group Chemical group 0.000 abstract 1
- 125000001984 thiazolidinyl group Chemical group 0.000 abstract 1
- 125000001425 triazolyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente se refiere a los amino-bencimidazoles que tienen actividad inhibitoria sobre la replicacion del virus sincitial respiratorio y que tienen la formula (1) sus prodrogas, N-oxidos, sales de adicion, aminas cuaternarias, complejos de metal y formas estereoquímicamente isoméricas donde Q es Ar1 o alquilo C1-6 sustituidos por uno o más sustituyentes seleccionados a partir de trifluorometilo, cicloalquilo C3-7, Ar2, hidroxi, alcoxi C1-4, alquiltio C1-4, Ar2-oxi-, Ar2-tio-, Ar2(CH2)noxi, Ar2(CH2)ntio, hidroxicarbonilo, aminocarbonilo, alquilcarbonilo C1-4, Ar2carbonilo, alcoxicarbonilo C1-4, Ar2(CH2)ncarbonilo, aminocarboniloxi, alquilcarboniloxi C1-4, Ar2carboniloxi, Ar2(CH2)ncarboniloxi, hidroxi-C2-4-alquiloxi, C1- 4alcoxicarbonil(CH2)noxi, mono- o di(C1-4alquil)-aminocarbonilo, mono- o di(C1-4alquil)aminocarboniloxi, aminosulfonilo, mono- o di(C1-4alquil)aminosulfonilo, dioxolanilo sustituido de manera opcional por uno o dos radicales alquilo C1-6 y un heterociclo seleccionado a partir de pirrolidinilo, pirrolilo, dihidropirrolilo, tiazolidinilo, imidazolilo, triazolilo, piperidinilo, homopiperidinilo, piperacinilo, piridilo y tetrahidropiridilo, cada uno de los cuales puede ser opcionalmente sustituido por oxo o alquilo C1-6; G es un enlace directo o sustituido de manera opcional alcanodiilo C1-10, R1 es Ar1 o un heterociclo monocíclico o bicíclico; uno de R2a y R3a es alquilo C1-6 y el otro de R2a y R3a es H, en caso de que R2a sea diferente de H, R2b es H o alquilo C1-6, y R3b es H, en caso de que R3a sea diferente de H, R3b es H o alquilo C1-6, y R2b es H; Ar1 es fenilo o fenilo sustituido y Ar2 es fenilo o fenilo sustituido. Además se refiere a su preparacion y a las composiciones que los comprenden, al igual que a su uso como un medicamento.This refers to amino-benzimidazoles that have inhibitory activity on the replication of respiratory syncytial virus and that have the formula (1) their prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms where Q is Ar1 or C1-6 alkyl substituted by one or more substituents selected from trifluoromethyl, C3-7 cycloalkyl, Ar2, hydroxy, C1-4 alkoxy, C1-4 alkylthio, Ar2-oxy-, Ar2-thio-, Ar2 (CH2) noxy, Ar2 (CH2) nthio, hydroxycarbonyl, aminocarbonyl, C1-4 alkylcarbonyl, Ar2carbonyl, C1-4 alkoxycarbonyl, Ar2 (CH2) ncarbonylo, aminocarbonyloxy, C1-4 alkylcarbonyloxy, Ar2carbonyloxy, Ar2 (CH2) n-carbonyloxy, hydroxy C2-4-alkyloxy, C1-4alkoxycarbonyl (CH2) noxy, mono- or di (C1-4alkyl) -aminocarbonyl, mono- or di (C1-4alkyl) aminocarbonyloxy, aminosulfonyl, mono- or di (C1-4alkyl) aminosulfonyl, dioxolanyl optionally substituted by one or two C1-6 alkyl radicals and a heterocycle selected or from pyrrolidinyl, pyrrolyl, dihydropyrrolyl, thiazolidinyl, imidazolyl, triazolyl, piperidinyl, homopiperidinyl, piperazinyl, pyridyl and tetrahydropyridyl, each of which may be optionally substituted by oxo or C1-6 alkyl; G is a direct or optionally substituted C1-10 alkanediyl bond, R1 is Ar1 or a monocyclic or bicyclic heterocycle; one of R2a and R3a is C1-6 alkyl and the other of R2a and R3a is H, in case R2a is different from H, R2b is H or C1-6 alkyl, and R3b is H, in case R3a is different from H, R3b is H or C1-6 alkyl, and R2b is H; Ar1 is phenyl or substituted phenyl and Ar2 is phenyl or substituted phenyl. It also refers to its preparation and the compositions that comprise them, as well as its use as a medicine.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03104804 | 2003-12-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR046972A1 true AR046972A1 (en) | 2006-01-04 |
Family
ID=34924151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040104810 AR046972A1 (en) | 2003-12-18 | 2004-12-20 | DERIVATIVES OF AMINO-BENCIMIDAZOLS AS INHIBITORS OF THE REPLICATION OF RESPIRATORY SYNCTIAL VIRUSES |
Country Status (4)
| Country | Link |
|---|---|
| CN (1) | CN1894236B (en) |
| AR (1) | AR046972A1 (en) |
| MY (1) | MY140893A (en) |
| TW (1) | TWI378926B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103356650A (en) * | 2013-07-04 | 2013-10-23 | 丁圣雨 | Application of Chukrasone A in preparing medicines for treating respiratory syncytial virus |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2731707B1 (en) * | 1995-03-13 | 1997-04-30 | Synthelabo | BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
| HK1046141B (en) * | 1999-06-28 | 2006-09-22 | 詹森药业有限公司 | Respiratory syncytial virus replication inhibitors |
| KR100731271B1 (en) * | 1999-06-28 | 2007-06-21 | 얀센 파마슈티카 엔.브이. | Respiratory synthium virus replication inhibitor |
| DE60008382T2 (en) * | 1999-06-28 | 2004-12-02 | Janssen Pharmaceutica N.V. | RESPIRATORY SYNCYTIAL VIRUS REPLICATION INHIBITORS |
-
2004
- 2004-12-20 MY MYPI20045255 patent/MY140893A/en unknown
- 2004-12-20 CN CN2004800372812A patent/CN1894236B/en not_active Expired - Lifetime
- 2004-12-20 AR ARP040104810 patent/AR046972A1/en not_active Application Discontinuation
- 2004-12-20 TW TW93139736A patent/TWI378926B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| TWI378926B (en) | 2012-12-11 |
| TW200531971A (en) | 2005-10-01 |
| CN1894236A (en) | 2007-01-10 |
| MY140893A (en) | 2010-01-29 |
| CN1894236B (en) | 2011-08-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |