AR046871A1 - Compuestos aromaticos como ligandos activadores de los receptores rars, composiciones farmaceuticas y cosmeticas que los contienen y su uso en dermatologia. - Google Patents

Compuestos aromaticos como ligandos activadores de los receptores rars, composiciones farmaceuticas y cosmeticas que los contienen y su uso en dermatologia.

Info

Publication number
AR046871A1
AR046871A1 ARP040104543A ARP040104543A AR046871A1 AR 046871 A1 AR046871 A1 AR 046871A1 AR P040104543 A ARP040104543 A AR P040104543A AR P040104543 A ARP040104543 A AR P040104543A AR 046871 A1 AR046871 A1 AR 046871A1
Authority
AR
Argentina
Prior art keywords
radical
alkyl radical
hydrogen atom
given below
alkyl
Prior art date
Application number
ARP040104543A
Other languages
English (en)
Inventor
Thibaud Biadatti
Jean-Marie Arlabosse
Original Assignee
Galderma Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Res & Dev filed Critical Galderma Res & Dev
Publication of AR046871A1 publication Critical patent/AR046871A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/19—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups having unsaturation outside the aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/28—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/003—Esters of saturated alcohols having the esterified hydroxy group bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/007—Esters of unsaturated alcohols having the esterified hydroxy group bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/63—Halogen-containing esters of saturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/64—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with oxygen atoms directly attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Abstract

Composiciones farmacéuticas destinadas a un uso en medicina humana o veterinaria, o incluso en composiciones cosméticas. Reivindicación 1: Compuestos caracterizados porque responden a la fórmula (1), en la cual: Ar representa un radical elegido entre los radicales del grupo de fórmulas (2), R7 e Y tienen las significaciones dadas más adelante; R1 representa un radical: a) un átomo de hidrógeno, b) un radical alquilo C1-6, c) un radical de fórmula: -N(-R´)-R", d) un radical -OR8; R, R'' y R8 tienen las significaciones dadas más adelante; R2 representa un átomo de hidrógeno, o unradical alquilo C1-6; R3 representa un átomo de hidrógeno, radical alquilo C1-6 o un radical -CO-R9, R9 tiene la significación dada más adelante; R4 y R5 tomados en forma conjunta, pueden formar con el ciclo aromático adyacente, un ciclo de 5 ó 6 eslabones, eventualmente sustituido por grupos metilo, y/o eventualmente interrumpido por un átomo de oxígeno o de azufre; R6 representa radical alquilo C1- 6 o un radical (CO)R10, R10 tiene las significaciones dadas más adelante; R7 representa un átomo de hidrógeno, un átomo de halógeno, un radical alquilo C1-6 o un radical -OR11, R11 tiene la significación dada más adelante; R8 representa un átomo de hidrógeno, un radical alquilo lineal o ramificado C1-20, un radical alquenilo, un radical mono o polihidroxialquilo, un radical arilo o aralquilo, eventualmente sustituido, o un resto de azúcar, o un resto de aminoácido o de péptido; R9 y R10 representa CF3 o un radical alquilo C1-6; R11 representa H, un radical alquilo C1-6, o un radical (CO)-R12, R12 tiene la significación dada más adelante; R12 representa un radical alquilo C1-6; R' y R'', representan un átomo de hidrógeno, un radical alquilo C1-6, un radical mono o polihidroxialquilo, un radical arilo, eventualmente sustituido o un resto de aminoácido o de péptido, o de azúcar o incluso, tomados juntos, forman un heterociclo; Y representa un átomo de oxígeno o de azufre; n es un entero comprendido entre 2 y 6, y las sales de los compuestos de fórmula (1) cuando R1 representa una función OH, así como los isómeros ópticos y geométricos de dichos compuestos de fórmula (1).
ARP040104543A 2003-12-08 2004-12-06 Compuestos aromaticos como ligandos activadores de los receptores rars, composiciones farmaceuticas y cosmeticas que los contienen y su uso en dermatologia. AR046871A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0314336A FR2863266B1 (fr) 2003-12-08 2003-12-08 NOUVEAUX LIGANDS ACTIVATEURS DES RECEPTEURS RARs, UTILISATION EN MEDECINES HUMAINE AINSI QU'EN COSMETIQUE

Publications (1)

Publication Number Publication Date
AR046871A1 true AR046871A1 (es) 2005-12-28

Family

ID=34586357

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040104543A AR046871A1 (es) 2003-12-08 2004-12-06 Compuestos aromaticos como ligandos activadores de los receptores rars, composiciones farmaceuticas y cosmeticas que los contienen y su uso en dermatologia.

Country Status (7)

Country Link
EP (1) EP1694627B1 (es)
AR (1) AR046871A1 (es)
AT (1) ATE432254T1 (es)
CA (1) CA2545112C (es)
ES (1) ES2326741T3 (es)
FR (1) FR2863266B1 (es)
WO (1) WO2005056510A2 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2894141A1 (fr) * 2005-12-06 2007-06-08 Galderma Res & Dev Composition depigmentante de la peau compreant un derive d'acide naphtoique
FR2931661B1 (fr) 2008-05-30 2010-07-30 Galderma Res & Dev Nouvelles compositions depigmentantes sous forme d'une composition anhydre sans vaseline et sans elastomere comprenant un derive phenolique solubilise et un retinoide.
CN102911073B (zh) * 2012-10-19 2014-12-17 哈尔滨工程大学 一种n-(4-乙炔基苯基羰基）-l-苯甘氨酸乙酯及制备方法
CN102924316A (zh) * 2012-10-19 2013-02-13 哈尔滨工程大学 一种光学活性苯乙炔衍生物及合成方法
US20200131123A1 (en) 2017-07-06 2020-04-30 Jiangsu Hengrui Medicine Co., Ltd. Indole-formamide derivative, preparation method therefor and use thereof in medicine
CN109963836B (zh) 2017-09-12 2022-11-22 江苏恒瑞医药股份有限公司 氘原子取代的吲哚甲酰胺类衍生物、其制备方法及其在医药上的应用
US20220339322A1 (en) 2019-10-02 2022-10-27 Inserm (Institut National De La Santé Et De La Researche Médecale) Use of retinoic acid receptor (rar) agonists for reversing, preventing, or delaying calcification of aortic valve

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2713635B1 (fr) * 1993-12-15 1996-01-05 Cird Galderma Nouveaux composés propynyl bi-aromatiques, compositions pharmaceutiques et cosmétiques les contenant et utilisations.

Also Published As

Publication number Publication date
ES2326741T3 (es) 2009-10-19
CA2545112A1 (en) 2005-06-23
EP1694627A2 (en) 2006-08-30
FR2863266B1 (fr) 2006-01-27
CA2545112C (en) 2013-07-02
FR2863266A1 (fr) 2005-06-10
EP1694627B1 (en) 2009-05-27
ATE432254T1 (de) 2009-06-15
WO2005056510A2 (en) 2005-06-23
WO2005056510A3 (en) 2005-08-11

Similar Documents

Publication Publication Date Title
AR033620A1 (es) Compuestos de sulfonilo de alfa-aminoacidos, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
ECSP078064A (es) NUEVOS DERIVADOS de 2,4-DIANILINOPIRIMIDINAS, SU PREPARACIÓN, COMO MEDICAMENTOS, COMPOSICIONES FARMACÉUTICAS Y PRINCIPALMENTE COMO INHIBIDORES DE IKK
ECSP055853A (es) Nuevos derivados de fluoroglicosidos heterociclicos, productos farmaceuticos que contienen dichos compuestos, y el uso de los mismos
AR051577A1 (es) Derivados eter sustituidos por hexafluorisopropanol
AR013494A1 (es) Derivados de carboxamidotiazoles, su preparacion, composiciones farmaceuticas que los contienen
AR055297A1 (es) Ligandos moduladores de los receptores rars, utilizacion en medicina humana asi como en cosmetica
AR056511A1 (es) Derivados de 2-aminopirimidinas, composiciones farmaceuticas que los contienen y su uso en la preparacion de medicamentos para el tratamiento de enfermedades mediadas por el receptor de histamina h4
ECSP066383A (es) Derivados de 5-fenil-4-metil-tiazol-2-il-amina como inhibidores de enzimas de cinasa fosfatidilinositol 3 (pi3) para el tratamiento de enfermedades inflamatorias de las vías respiratorias
EA200701176A1 (ru) Новые соединения нафталина, способ их получения и фармацевтические композиции, содержащие их
CR10027A (es) Nuevos derivados de pirrol fusionado
AR032888A1 (es) Compuestos bifenilo,su utilizacion, composicion cosmetica, utilizacion cosmetica de dicha composicion y composicion farmaceutica
AR063988A1 (es) Derivados heterociclicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen
AR053554A1 (es) Derivados de pirimidina para el tratamiento de trastornos hiperproliferativos
AR058155A1 (es) Compuestos biaromaticos moduladores de ppars
CY1116168T1 (el) Συγκρυσταλλοι και αλατα αναστολεων toy ccr3
AR083903A1 (es) Derivados de benzooxazol y benzotiazol sulfonamidas, utiles para tratar trastornos del ritmo cardiaco y cancer, composiciones farmaceuticas que los contienen y metodo para prepararlos
AR054341A1 (es) Combinaciones sinergicas de compuestos activos fungicidas
NI201000134A (es) Nuevos derivados dihidroindolonas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
AR046871A1 (es) Compuestos aromaticos como ligandos activadores de los receptores rars, composiciones farmaceuticas y cosmeticas que los contienen y su uso en dermatologia.
AR036634A1 (es) Composicion de tenido que contiene un compuesto de para-aminofenol o para-fenilen diamina sustituido por un radical silanico
AR054678A1 (es) Compuestos bi-aromaticos activadores de los receptores del tipo ppar y su utilizacion en composiciones cosmeticas o farmaceuticas y dichas composiciones
AR050695A1 (es) Compuestos biaromaticos activadores de los receptores de tipo ppar y su utilizacion en composiciones cosmeticas o farmaceuticas
AR086803A1 (es) Derivados de oxazetidinas, composiciones farmaceuticas y cosmeticas que los contienen y uso de los mismos para tratar enfermedades dermatologicas fundamentalmente, y del aparato respiratorio, digestivo y cardiovascular, entre otras
AR046111A1 (es) Derivados del acido benzoico como ligandos activadores de los receptores rars y su utilizacion en composiciones farmaceuticas asi como tambien en cosmetica.
AR072103A1 (es) Derivados de (piperazinilo con enlaces puente)-1- alcanona, su utilizacion como inhibidores de p75 y composiciones farmaceuticas que los contienen

Legal Events

Date Code Title Description
FB Suspension of granting procedure