AR045599A1 - Fosfodiesterasas especificas de nucleotidos monofosfato ciclicos obtenidas a partir de leishmania y uso de las mismas - Google Patents
Fosfodiesterasas especificas de nucleotidos monofosfato ciclicos obtenidas a partir de leishmania y uso de las mismasInfo
- Publication number
- AR045599A1 AR045599A1 ARP040103197A ARP040103197A AR045599A1 AR 045599 A1 AR045599 A1 AR 045599A1 AR P040103197 A ARP040103197 A AR P040103197A AR P040103197 A ARP040103197 A AR P040103197A AR 045599 A1 AR045599 A1 AR 045599A1
- Authority
- AR
- Argentina
- Prior art keywords
- sequences
- nucleic acid
- leishmania
- amino acid
- monofosfato
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Secuencias de aminoácidos y de ácidos nucleicos de fosfodiesterasa específicas de nucleótidos monofosfato cíclicos obtenidos del parásito Leishmania major. Construcciones y vectores de ácidos nucleicos, y células huésped, que comprenden las secuencias de ácidos nucleicos como así también métodos para producir y utilizar las secuencias de aminoácidos y de ácido nucleicos. Utilización de estas secuencias, y anticuerpo dirigidos contra estas secuencias, en el diagnóstico y tratamiento de trastornos relacionados con la infección por Leishmania major, que incluyen la identificación de compuestos que forman complejos con dichos polipéptidos y ácidos nucleicos. Reivindicación 1: Una proteína sustancialmente purificada, que comprende la secuencia de aminoácidos indicada en SEC ID NO: 1 o variantes y mutantes de la misma que tienen una identidad de por lo menos el 80 % con la SEC ID NO: 1 y que hidrolizan el AMPc.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50024403P | 2003-09-05 | 2003-09-05 | |
| US50407003P | 2003-09-19 | 2003-09-19 | |
| US58258404P | 2004-06-25 | 2004-06-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR045599A1 true AR045599A1 (es) | 2005-11-02 |
Family
ID=34279822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040103197A AR045599A1 (es) | 2003-09-05 | 2004-09-06 | Fosfodiesterasas especificas de nucleotidos monofosfato ciclicos obtenidas a partir de leishmania y uso de las mismas |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US7785849B2 (es) |
| EP (1) | EP1664289B1 (es) |
| AR (1) | AR045599A1 (es) |
| AT (1) | ATE492632T1 (es) |
| AU (1) | AU2004270494B2 (es) |
| CA (1) | CA2538012A1 (es) |
| DE (1) | DE602004030695D1 (es) |
| DK (1) | DK1664289T3 (es) |
| PL (1) | PL1664289T3 (es) |
| PT (1) | PT1664289E (es) |
| TW (1) | TW200518770A (es) |
| WO (1) | WO2005023856A2 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007124115A2 (en) * | 2006-04-20 | 2007-11-01 | Trustees Of Boston College | Compositions and methods for identifying inhibitors and activators of cyclic amp phosphodiesterases |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002022661A2 (en) * | 2000-09-12 | 2002-03-21 | Beavo Joseph A | NOVEL PDEs AND USES THEREOF |
-
2004
- 2004-09-03 US US10/570,350 patent/US7785849B2/en not_active Expired - Fee Related
- 2004-09-03 AT AT04787575T patent/ATE492632T1/de active
- 2004-09-03 AU AU2004270494A patent/AU2004270494B2/en not_active Ceased
- 2004-09-03 WO PCT/IB2004/003990 patent/WO2005023856A2/en active Application Filing
- 2004-09-03 CA CA002538012A patent/CA2538012A1/en not_active Abandoned
- 2004-09-03 DE DE602004030695T patent/DE602004030695D1/de active Active
- 2004-09-03 EP EP04787575A patent/EP1664289B1/en not_active Not-in-force
- 2004-09-03 PL PL04787575T patent/PL1664289T3/pl unknown
- 2004-09-03 DK DK04787575.2T patent/DK1664289T3/da active
- 2004-09-03 PT PT04787575T patent/PT1664289E/pt unknown
- 2004-09-06 AR ARP040103197A patent/AR045599A1/es unknown
- 2004-09-06 TW TW093126897A patent/TW200518770A/zh unknown
-
2010
- 2010-06-11 US US12/814,352 patent/US20110045491A1/en not_active Abandoned
-
2011
- 2011-06-09 US US13/157,145 patent/US20130143250A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PT1664289E (pt) | 2011-03-17 |
| CA2538012A1 (en) | 2005-03-17 |
| WO2005023856A2 (en) | 2005-03-17 |
| US20110045491A1 (en) | 2011-02-24 |
| DE602004030695D1 (de) | 2011-02-03 |
| US20130143250A1 (en) | 2013-06-06 |
| EP1664289B1 (en) | 2010-12-22 |
| AU2004270494B2 (en) | 2010-10-14 |
| ATE492632T1 (de) | 2011-01-15 |
| US20070292847A1 (en) | 2007-12-20 |
| PL1664289T3 (pl) | 2011-05-31 |
| US7785849B2 (en) | 2010-08-31 |
| WO2005023856A3 (en) | 2005-06-02 |
| TW200518770A (en) | 2005-06-16 |
| DK1664289T3 (da) | 2011-02-14 |
| AU2004270494A1 (en) | 2005-03-17 |
| EP1664289A2 (en) | 2006-06-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |