AR045408A1 - GENES AND POLYPEPTIDES RELATED TO CANCER OF HUMAN COLON - Google Patents

GENES AND POLYPEPTIDES RELATED TO CANCER OF HUMAN COLON

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Publication number
AR045408A1
AR045408A1 ARP030104390A ARP030104390A AR045408A1 AR 045408 A1 AR045408 A1 AR 045408A1 AR P030104390 A ARP030104390 A AR P030104390A AR P030104390 A ARP030104390 A AR P030104390A AR 045408 A1 AR045408 A1 AR 045408A1
Authority
AR
Argentina
Prior art keywords
polypeptide
seq
polynucleotide
amino acid
acid sequence
Prior art date
Application number
ARP030104390A
Other languages
Spanish (es)
Original Assignee
Oncotherapy Science Inc
Japan As Represented By Th Epr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP2003/007006 external-priority patent/WO2003104275A2/en
Application filed by Oncotherapy Science Inc, Japan As Represented By Th Epr filed Critical Oncotherapy Science Inc
Publication of AR045408A1 publication Critical patent/AR045408A1/en

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  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Nuevo gen humano RNF 43 cuya expresión está marcadamente elevada en el cáncer colorrectal en comparación con los correspondientes tejidos no cancerosos. Los genes y los polipéptidos codificados por los genes se pueden usar, por ejemplo, en el diagnóstico de una enfermedad de células proliferativas, y como moléculas blanco para desarrollar fármacos contra la enfermedad. Reivindicación 1: Un polipéptido sustancialmente puro, caracterizado porque se selecciona del grupo formado por: a) un polipéptido que comprende la secuencia de aminoácidos de la SEQ ID N°: 2; b) un polipéptido que comprende la secuencia de aminoácidos de la SEQ ID N°: 2 en la cual se ha sustituido, suprimido, insertado y/o añadido uno o más aminoácidos y que posee una actividad biológica equivalente a una proteína que comprende la secuencia de aminoácidos de la SEQ ID N°: 2; y c) un polipéptido codificado por un polinucleótido que se hibridiza bajo condiciones severas con un polinucleótido que comprende la secuencia de nucleótidos de la SEQ ID N°: 1, donde el polipéptido posee una actividad biológica equivalente a un polipéptido que comprende la secuencia de aminoácidos de la SEQ ID N°: 2. Reivindicación 9: El polinucleótido antisentido de la cláusula 8, caracterizado porque se selecciona del grupo formado por nucleótidos que comprende la secuencia de nucleótidos de la SEQ ID N°: 10. Reivindicación 21: Una composición para tratar una enfermedad de células proliferativas, caracterizada porque dicha composición comprende una cantidad eficaz para uso farmacéutico de un anticuerpo contra un polipéptido seleccionado del grupo formado por: a) un polipéptido que comprende la secuencia de aminoácidos de la SEQ ID N°: 2; b) un polipéptido que comprende la secuencia de aminoácidos de la SEQ ID N°: 2 en la cual se ha sustituido, suprimido, insertado y/o añadido uno o más aminoácidos y que posee una actividad biológica equivalente de una proteína que comprende la secuencia de aminoácidos de la SEQ ID N°: 2; y c) un polipéptido codificado por un polinucleótido que se hibridiza bajo condiciones severas con un polinucleótido que comprende la secuencia de nucleótidos de la SEQ ID N°: 1, donde el polipéptido presenta una actividad biológica equivalente de un polipéptido que comprende la secuencia de aminoácidos de la SEQ ID N°: 2, como ingrediente activo y un vehículo aceptable para uso farmacéutico. Reivindicación 30: Un método para inducir inmunidad anti-tumoral, caracterizado porque dicho método comprende el paso de poner un polipéptido seleccionado del grupo formado por a)-c) en contacto con células presentadoras de antígenos, o introducir un polinucleótido que codifica el polipéptido o un vector que comprende el polinucleótido en células presentadoras de antígenos: a) un polipéptido que comprende la secuencia de aminoácidos de la SEQ ID N°: 2, o un fragmento del mismo; b) un polipéptido que comprende la secuencia de aminoácidos de la SEQ ID N°: 2 en la cual se ha sustituido, suprimido, insertado y/o añadido uno o más aminoácidos y que posee una actividad biológica equivalente de una proteína que comprende la secuencia de aminoácidos de la SEQ ID N°: 2, o un fragmento del mismo; c) un polipéptido codificado por un polinucleótido que se hibridiza bajo condiciones severas con un polinucleótido que comprende la secuencia de nucleótidos de la SEQ ID N°: 1, donde el polipéptido presenta una actividad biológica equivalente de un polipéptido que comprende la secuencia de aminoácidos de la SEQ ID N°: 2, o un fragmento del mismo.New human gene RNF 43 whose expression is markedly elevated in colorectal cancer compared to the corresponding non-cancerous tissues. Genes and polypeptides encoded by genes can be used, for example, in the diagnosis of a proliferative cell disease, and as white molecules to develop drugs against the disease. Claim 1: A substantially pure polypeptide, characterized in that it is selected from the group consisting of: a) a polypeptide comprising the amino acid sequence of SEQ ID N °: 2; b) a polypeptide comprising the amino acid sequence of SEQ ID N °: 2 in which one or more amino acids have been substituted, deleted, inserted and / or added and possessing a biological activity equivalent to a protein comprising the sequence of amino acids of SEQ ID N °: 2; and c) a polypeptide encoded by a polynucleotide that hybridizes under severe conditions with a polynucleotide comprising the nucleotide sequence of SEQ ID N °: 1, wherein the polypeptide possesses a biological activity equivalent to a polypeptide comprising the amino acid sequence of SEQ ID N °: 2. Claim 9: The antisense polynucleotide of clause 8, characterized in that it is selected from the group consisting of nucleotides comprising the nucleotide sequence of SEQ ID N °: 10. Claim 21: A composition for treating a proliferative cell disease, characterized in that said composition comprises an amount effective for pharmaceutical use of an antibody against a polypeptide selected from the group consisting of: a) a polypeptide comprising the amino acid sequence of SEQ ID N °: 2; b) a polypeptide comprising the amino acid sequence of SEQ ID N °: 2 in which one or more amino acids have been substituted, deleted, inserted and / or added and possessing an equivalent biological activity of a protein comprising the sequence of amino acids of SEQ ID N °: 2; and c) a polypeptide encoded by a polynucleotide that hybridizes under severe conditions with a polynucleotide comprising the nucleotide sequence of SEQ ID N °: 1, wherein the polypeptide exhibits an equivalent biological activity of a polypeptide comprising the amino acid sequence of SEQ ID N °: 2, as active ingredient and a vehicle acceptable for pharmaceutical use. Claim 30: A method for inducing anti-tumor immunity, characterized in that said method comprises the step of placing a polypeptide selected from the group consisting of a) -c) in contact with antigen presenting cells, or introducing a polynucleotide encoding the polypeptide or a vector comprising the polynucleotide in antigen presenting cells: a) a polypeptide comprising the amino acid sequence of SEQ ID N °: 2, or a fragment thereof; b) a polypeptide comprising the amino acid sequence of SEQ ID N °: 2 in which one or more amino acids have been substituted, deleted, inserted and / or added and possessing an equivalent biological activity of a protein comprising the sequence of amino acids of SEQ ID N °: 2, or a fragment thereof; c) a polypeptide encoded by a polynucleotide that hybridizes under severe conditions with a polynucleotide comprising the nucleotide sequence of SEQ ID N °: 1, wherein the polypeptide exhibits an equivalent biological activity of a polypeptide comprising the amino acid sequence of SEQ ID N °: 2, or a fragment thereof.

ARP030104390A 2003-02-28 2003-11-27 GENES AND POLYPEPTIDES RELATED TO CANCER OF HUMAN COLON AR045408A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45101303P 2003-02-28 2003-02-28
PCT/JP2003/007006 WO2003104275A2 (en) 2002-06-06 2003-06-03 Genes and polypeptides relating to human colon cancers

Publications (1)

Publication Number Publication Date
AR045408A1 true AR045408A1 (en) 2005-10-26

Family

ID=42778403

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP030104390A AR045408A1 (en) 2003-02-28 2003-11-27 GENES AND POLYPEPTIDES RELATED TO CANCER OF HUMAN COLON
ARP100102600 AR077577A2 (en) 2003-02-28 2010-07-15 POLIPEPTIDES RELATED TO CANCER OF HUMAN COLON, POLYUCLEOTIDES THAT CODE IT, VECTOR, USES AND PHARMACEUTICAL COMPOSITIONS

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP100102600 AR077577A2 (en) 2003-02-28 2010-07-15 POLIPEPTIDES RELATED TO CANCER OF HUMAN COLON, POLYUCLEOTIDES THAT CODE IT, VECTOR, USES AND PHARMACEUTICAL COMPOSITIONS

Country Status (2)

Country Link
AR (2) AR045408A1 (en)
TW (1) TWI324608B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI610939B (en) * 2007-02-21 2018-01-11 腫瘤療法 科學股份有限公司 Peptide vaccines for cancers expressing tumor-associated antigens
TW201008574A (en) 2008-08-19 2010-03-01 Oncotherapy Science Inc INHBB epitope peptides and vaccines containing the same
BRPI0923402A2 (en) 2008-12-24 2015-08-04 Oncotherapy Science Inc C10rf59 peptides and vaccines including the same.

Also Published As

Publication number Publication date
TWI324608B (en) 2010-05-11
TW200502247A (en) 2005-01-16
AR077577A2 (en) 2011-09-07

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