AR043594A1 - A PROCEDURE FOR THE PREPARATION OF CALCIUM SALT OF ACID (E) -7- [4- (4-FLUOROPHENIL) -6-ISOPROPIL-2- [METHYL (METHYL-SULFONYL) AMINO] PIRIMIDIN-5-IL] (3R , 5S) -3,5-DIHYDROXIHEPT-6-ENOICO AND COMPOUND USED IN SUCH PROCEDURE - Google Patents

A PROCEDURE FOR THE PREPARATION OF CALCIUM SALT OF ACID (E) -7- [4- (4-FLUOROPHENIL) -6-ISOPROPIL-2- [METHYL (METHYL-SULFONYL) AMINO] PIRIMIDIN-5-IL] (3R , 5S) -3,5-DIHYDROXIHEPT-6-ENOICO AND COMPOUND USED IN SUCH PROCEDURE

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Publication number
AR043594A1
AR043594A1 ARP040100831A ARP040100831A AR043594A1 AR 043594 A1 AR043594 A1 AR 043594A1 AR P040100831 A ARP040100831 A AR P040100831A AR P040100831 A ARP040100831 A AR P040100831A AR 043594 A1 AR043594 A1 AR 043594A1
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Argentina
Prior art keywords
methyl
procedure
amino
preparation
calcium salt
Prior art date
Application number
ARP040100831A
Other languages
Spanish (es)
Inventor
Narendra Shriram Joshi
Kodali Eswara Rao
Shekhar Bhaskar Bhirud
Chandrasekhar Batchu
Original Assignee
Glenmark Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Glenmark Pharmaceuticals Ltd filed Critical Glenmark Pharmaceuticals Ltd
Publication of AR043594A1 publication Critical patent/AR043594A1/en

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Abstract

Un procedimiento para la preparación de la sal de calcio del ácido (E)-7-[4-(4-fluorofenil)-6-isopropil-2-[metil (metilsulfonil) amino]pirimidin-5-il](3R,5S)-3,5-dihidroxihept-6-enoico, que comprende: i) la preparación del bromo de [4-(4-fluorofenil)-6-isopropil-2-[metil (metilsulfonil) amino]pirimidin-5-ilmetil]fosfonio (TPPBr) de fórmula (1); ii) reacción del TPPBr con acetato de tert-butil 2-(4R, 6S)-6-formil-2,2-dimetil-1,3-dioxan-4-il (BFA) de fórmula (2) para formar el acetato de tert-butil (E)-6-{2.[4-fluorofenil-6-isopropil-2-metil (metilsulfonil) amino]pirimidin-5-il]vinil}-(4R,6S)-2,2-dimetil[1,3]-dioxan-4-il (BEM) de fórmula (3); iii) preparación de la sal de metilamonio de Rosuvastatina y iv) conversión de la sal de metilamonio de Rosuvastatina en la sal de calcio de Rosuvastatina.A process for the preparation of the calcium salt of (E) -7- [4- (4-fluorophenyl) -6-isopropyl-2- [methyl (methylsulfonyl) amino] pyrimidin-5-yl] (3R, 5S ) -3,5-dihydroxyhept-6-enoic, comprising: i) the preparation of [4- (4-fluorophenyl) -6-isopropyl-2- [methyl (methylsulfonyl) amino] pyrimidin-5-ylmethyl] bromine phosphonium (TPPBr) of formula (1); ii) reaction of TPPBr with tert-butyl acetate 2- (4R, 6S) -6-formyl-2,2-dimethyl-1,3-dioxan-4-yl (BFA) of formula (2) to form acetate of tert-butyl (E) -6- {2. [4-fluorophenyl-6-isopropyl-2-methyl (methylsulfonyl) amino] pyrimidin-5-yl] vinyl} - (4R, 6S) -2,2-dimethyl [1,3] -dioxan-4-yl (BEM) of formula (3); iii) preparation of the methylammonium salt of Rosuvastatin and iv) conversion of the methylammonium salt of Rosuvastatin into the calcium salt of Rosuvastatin.

ARP040100831A 2003-12-04 2004-03-12 A PROCEDURE FOR THE PREPARATION OF CALCIUM SALT OF ACID (E) -7- [4- (4-FLUOROPHENIL) -6-ISOPROPIL-2- [METHYL (METHYL-SULFONYL) AMINO] PIRIMIDIN-5-IL] (3R , 5S) -3,5-DIHYDROXIHEPT-6-ENOICO AND COMPOUND USED IN SUCH PROCEDURE AR043594A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN1244MU2003 2003-12-04

Publications (1)

Publication Number Publication Date
AR043594A1 true AR043594A1 (en) 2005-08-03

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Application Number Title Priority Date Filing Date
ARP040100831A AR043594A1 (en) 2003-12-04 2004-03-12 A PROCEDURE FOR THE PREPARATION OF CALCIUM SALT OF ACID (E) -7- [4- (4-FLUOROPHENIL) -6-ISOPROPIL-2- [METHYL (METHYL-SULFONYL) AMINO] PIRIMIDIN-5-IL] (3R , 5S) -3,5-DIHYDROXIHEPT-6-ENOICO AND COMPOUND USED IN SUCH PROCEDURE

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AR (1) AR043594A1 (en)

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