AR043594A1 - A PROCEDURE FOR THE PREPARATION OF CALCIUM SALT OF ACID (E) -7- [4- (4-FLUOROPHENIL) -6-ISOPROPIL-2- [METHYL (METHYL-SULFONYL) AMINO] PIRIMIDIN-5-IL] (3R , 5S) -3,5-DIHYDROXIHEPT-6-ENOICO AND COMPOUND USED IN SUCH PROCEDURE - Google Patents
A PROCEDURE FOR THE PREPARATION OF CALCIUM SALT OF ACID (E) -7- [4- (4-FLUOROPHENIL) -6-ISOPROPIL-2- [METHYL (METHYL-SULFONYL) AMINO] PIRIMIDIN-5-IL] (3R , 5S) -3,5-DIHYDROXIHEPT-6-ENOICO AND COMPOUND USED IN SUCH PROCEDUREInfo
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- AR043594A1 AR043594A1 ARP040100831A ARP040100831A AR043594A1 AR 043594 A1 AR043594 A1 AR 043594A1 AR P040100831 A ARP040100831 A AR P040100831A AR P040100831 A ARP040100831 A AR P040100831A AR 043594 A1 AR043594 A1 AR 043594A1
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- Argentina
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- methyl
- procedure
- amino
- preparation
- calcium salt
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Abstract
Un procedimiento para la preparación de la sal de calcio del ácido (E)-7-[4-(4-fluorofenil)-6-isopropil-2-[metil (metilsulfonil) amino]pirimidin-5-il](3R,5S)-3,5-dihidroxihept-6-enoico, que comprende: i) la preparación del bromo de [4-(4-fluorofenil)-6-isopropil-2-[metil (metilsulfonil) amino]pirimidin-5-ilmetil]fosfonio (TPPBr) de fórmula (1); ii) reacción del TPPBr con acetato de tert-butil 2-(4R, 6S)-6-formil-2,2-dimetil-1,3-dioxan-4-il (BFA) de fórmula (2) para formar el acetato de tert-butil (E)-6-{2.[4-fluorofenil-6-isopropil-2-metil (metilsulfonil) amino]pirimidin-5-il]vinil}-(4R,6S)-2,2-dimetil[1,3]-dioxan-4-il (BEM) de fórmula (3); iii) preparación de la sal de metilamonio de Rosuvastatina y iv) conversión de la sal de metilamonio de Rosuvastatina en la sal de calcio de Rosuvastatina.A process for the preparation of the calcium salt of (E) -7- [4- (4-fluorophenyl) -6-isopropyl-2- [methyl (methylsulfonyl) amino] pyrimidin-5-yl] (3R, 5S ) -3,5-dihydroxyhept-6-enoic, comprising: i) the preparation of [4- (4-fluorophenyl) -6-isopropyl-2- [methyl (methylsulfonyl) amino] pyrimidin-5-ylmethyl] bromine phosphonium (TPPBr) of formula (1); ii) reaction of TPPBr with tert-butyl acetate 2- (4R, 6S) -6-formyl-2,2-dimethyl-1,3-dioxan-4-yl (BFA) of formula (2) to form acetate of tert-butyl (E) -6- {2. [4-fluorophenyl-6-isopropyl-2-methyl (methylsulfonyl) amino] pyrimidin-5-yl] vinyl} - (4R, 6S) -2,2-dimethyl [1,3] -dioxan-4-yl (BEM) of formula (3); iii) preparation of the methylammonium salt of Rosuvastatin and iv) conversion of the methylammonium salt of Rosuvastatin into the calcium salt of Rosuvastatin.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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IN1244MU2003 | 2003-12-04 |
Publications (1)
Publication Number | Publication Date |
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AR043594A1 true AR043594A1 (en) | 2005-08-03 |
Family
ID=42778055
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040100831A AR043594A1 (en) | 2003-12-04 | 2004-03-12 | A PROCEDURE FOR THE PREPARATION OF CALCIUM SALT OF ACID (E) -7- [4- (4-FLUOROPHENIL) -6-ISOPROPIL-2- [METHYL (METHYL-SULFONYL) AMINO] PIRIMIDIN-5-IL] (3R , 5S) -3,5-DIHYDROXIHEPT-6-ENOICO AND COMPOUND USED IN SUCH PROCEDURE |
Country Status (1)
Country | Link |
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AR (1) | AR043594A1 (en) |
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2004
- 2004-03-12 AR ARP040100831A patent/AR043594A1/en unknown
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