AR042900A1 - Productos n-aril-heteroaromaticos, composiciones que les contienen y su utilizacion - Google Patents
Productos n-aril-heteroaromaticos, composiciones que les contienen y su utilizacionInfo
- Publication number
- AR042900A1 AR042900A1 ARP040100138A ARP040100138A AR042900A1 AR 042900 A1 AR042900 A1 AR 042900A1 AR P040100138 A ARP040100138 A AR P040100138A AR P040100138 A ARP040100138 A AR P040100138A AR 042900 A1 AR042900 A1 AR 042900A1
- Authority
- AR
- Argentina
- Prior art keywords
- aryl
- heteroaryl
- alkyl
- group
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Productos N-aril-heteroaromáticos, composiciones que les contienen, y su utilización como medicamento, en particular en oncología. Reivindicación 1: Producto que responde a la fórmula (1), en la cual: R1 y R2 se seleccionan independientemente del grupo constituido por arilo, heteroarilo, arilo sustituido y heteroarilo sustituido; R2 se puede igualmente elegir entre el grupo cicloalquilo C5-7; L se selecciona del grupo constituido por C(R7)(R8), C=O, C=S y C=N(R7); R3 se selecciona del grupo constituido por H, halógeno, CF3, alquilo, alquilo sustituido, alquileno, alquileno sustituido, alquinilo, alquinilo sustituido, cicloalquilo, cicloalquileno, heterociclilo, CO-R7, C[N-O(R8)](R7), COOH, CONH-arilo, CONH-heteroarilo, CONH-R7, CON(R7)(R8), CO-N(R7)-arilo, CO-N(R7)-heteroarilo, C(OR7)=NH, C[N(R7)(R8)]=NH, NH2, NH-arilo, NH-heteroarilo, NH(R7), N(R7)(R8), NH-CO-R7, N(R7)-CO-arilo, N(R7)-CO-heteroarilo, NH-SO2-R7, NH-SO2-arilo, NH-SO2-heteroarilo, NH-CH2-CO2R7, NH-CH2-arilo, NH-CH2-heteroarilo, N(R7)-N(R8)(R10), N-N=C(R7)(R8), CN, O-R7, S-R7, SO2-R7, SO2-R7, arilo, heteroarilo, cicloalquilo sustituido, arilo sustituido y heteroarilo sustituido; R4 se selecciona del grupo constituido por H, alquilo C1-3, ciclopropilo, alquileno C1-3, alquinilo C1-3, O-alquilo C1-3, S-alquilo C1-3, F, Cl y Br; R5 y R6 se seleccionan independientemente del grupo constituido por H, alquilo C1-3, oxo y halógeno; R7, R8 y R10 se seleccionan independientemente del grupo constituido por H, alquilo C1-3 y alquilo C1-3 sustituido; L-G-R1 se selecciona del grupo constituido por un resto de grupo de fórmula (2), con L y R1 son tales como se definen precedentemente, y R9 es igual a alquilo C1-3, bajo forma racémica, enriquecida con un enantiómero, enriquecida con un diastereoisómero, sus tautómeros, sus fármacos y sus sales farmacéuticamente aceptables, bajo reserva que el producto de fórmula (1) no sea uno de los compuestos de fórmula (3).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0300894A FR2850379B1 (fr) | 2003-01-28 | 2003-01-28 | Produits n-aryl-heteroaromatiques, compositions les contenant et utilisation |
Publications (1)
Publication Number | Publication Date |
---|---|
AR042900A1 true AR042900A1 (es) | 2005-07-06 |
Family
ID=32669255
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040100138A AR042900A1 (es) | 2003-01-28 | 2004-01-19 | Productos n-aril-heteroaromaticos, composiciones que les contienen y su utilizacion |
Country Status (9)
Country | Link |
---|---|
AR (1) | AR042900A1 (es) |
CL (1) | CL2004000045A1 (es) |
FR (1) | FR2850379B1 (es) |
GT (1) | GT200300267A (es) |
PA (1) | PA8594301A1 (es) |
PE (1) | PE20040766A1 (es) |
SV (1) | SV2004001710A (es) |
TW (1) | TW200504026A (es) |
UY (1) | UY28173A1 (es) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3449350A (en) * | 1968-06-24 | 1969-06-10 | Ciba Geigy Corp | Certain pyrazole-3-carboxylic acid hydrazide derivatives |
US3778433A (en) * | 1969-04-18 | 1973-12-11 | Sumitomo Chemical Co | Process for producing benzodiazepine derivatives |
JPS61129129A (ja) * | 1984-11-28 | 1986-06-17 | Kureha Chem Ind Co Ltd | 抗腫瘍剤 |
TW312694B (es) * | 1994-09-26 | 1997-08-11 | Daiichi Seiyaku Co | |
EP1411942A4 (en) * | 2001-07-05 | 2005-01-26 | Synaptic Pharma Corp | SUBSTITUTED ANILINE PIPERIDINES AS SELECTIVE MCH ANTAGONISTS |
-
2003
- 2003-01-28 FR FR0300894A patent/FR2850379B1/fr not_active Expired - Fee Related
- 2003-12-03 GT GT200300267A patent/GT200300267A/es unknown
- 2003-12-04 PE PE2003001229A patent/PE20040766A1/es not_active Application Discontinuation
-
2004
- 2004-01-13 CL CL200400045A patent/CL2004000045A1/es unknown
- 2004-01-19 AR ARP040100138A patent/AR042900A1/es unknown
- 2004-01-22 PA PA20048594301A patent/PA8594301A1/es unknown
- 2004-01-27 TW TW093101686A patent/TW200504026A/zh unknown
- 2004-01-27 SV SV2004001710A patent/SV2004001710A/es unknown
- 2004-01-28 UY UY28173A patent/UY28173A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
FR2850379A1 (fr) | 2004-07-30 |
GT200300267A (es) | 2004-02-24 |
PA8594301A1 (es) | 2004-08-31 |
TW200504026A (en) | 2005-02-01 |
SV2004001710A (es) | 2004-03-19 |
PE20040766A1 (es) | 2004-12-14 |
UY28173A1 (es) | 2004-08-31 |
FR2850379B1 (fr) | 2006-11-17 |
CL2004000045A1 (es) | 2005-01-07 |
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Legal Events
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FB | Suspension of granting procedure |