AR037415A1 - METHOD TO PRODUCE L-AMINO ACIDS USING BACTERIA THAT BELONG TO THE GENERO ESCHERICHIA - Google Patents

METHOD TO PRODUCE L-AMINO ACIDS USING BACTERIA THAT BELONG TO THE GENERO ESCHERICHIA

Info

Publication number
AR037415A1
AR037415A1 ARP020104508A ARP020104508A AR037415A1 AR 037415 A1 AR037415 A1 AR 037415A1 AR P020104508 A ARP020104508 A AR P020104508A AR P020104508 A ARP020104508 A AR P020104508A AR 037415 A1 AR037415 A1 AR 037415A1
Authority
AR
Argentina
Prior art keywords
amino acids
bacteria
amino acid
escherichia
bacterium
Prior art date
Application number
ARP020104508A
Other languages
Spanish (es)
Inventor
M Vitushkina
V Livshits
S Mashko
V Doroshenko
I Biryukova
Z Katahkina
A Skorokhodova
A Belareva
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26654105&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR037415(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from RU2001131571/13A external-priority patent/RU2001131571A/en
Priority claimed from RU2002121670/13A external-priority patent/RU2222596C1/en
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of AR037415A1 publication Critical patent/AR037415A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C12P13/222—Phenylalanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C12P13/227—Tryptophan
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Abstract

Métodos para producir L-aminoácidos, tal como L-fenilalanina y L-triptofano, usando bacterias que pertenecen al género Escherichia, donde la productividad de L-aminoácidos en dichas bacterias está aumentada debido a una mayor actividad de una proteína codificada por el gen yddG. Reivindicación 1: Una bacteria productora de L-aminoácidos que pertenece al género Escherichia, caracterizada porque la producción de L-aminoácidos por dicha bacteria está aumentada debido a una mayor actividad de una de las proteínas que se definen a continuación (A) ó (B) en una célula de dicha bacteria: (A) una proteína que comprende la secuencia de aminoácidos que se muestra en la SEQ ID N°: 2 del listado de secuencias; (B) una proteína que comprende una secuencia de aminoácidos que incluye una supresión, sustitución, inserción o adición de uno o varios aminoácidos en la secuencia de aminoácidos que se muestra en la SEQ ID N°: 2 del listado de secuencias y cuya actividad vuelve a las bacterias más resistentes a L-fenilalanina y/o un análogo del aminoácido.Methods for producing L-amino acids, such as L-phenylalanine and L-tryptophan, using bacteria belonging to the genus Escherichia, where the productivity of L-amino acids in such bacteria is increased due to increased activity of a protein encoded by the yddG gene . Claim 1: An L-amino acid producing bacterium belonging to the genus Escherichia, characterized in that the production of L-amino acids by said bacterium is increased due to a higher activity of one of the proteins defined below (A) or (B ) in a cell of said bacterium: (A) a protein comprising the amino acid sequence shown in SEQ ID N °: 2 of the sequence listing; (B) a protein comprising an amino acid sequence that includes a deletion, substitution, insertion or addition of one or more amino acids in the amino acid sequence shown in SEQ ID N °: 2 of the sequence listing and whose activity returns to the bacteria most resistant to L-phenylalanine and / or an amino acid analog.

ARP020104508A 2001-11-23 2002-11-22 METHOD TO PRODUCE L-AMINO ACIDS USING BACTERIA THAT BELONG TO THE GENERO ESCHERICHIA AR037415A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2001131571/13A RU2001131571A (en) 2001-11-23 The method of obtaining L-amino acids using bacteria belonging to the genus Escherichia
RU2002121670/13A RU2222596C1 (en) 2002-08-14 2002-08-14 Method for preparing l-amino acids, strain escherichia coli as producer of l-amino acid (variants)

Publications (1)

Publication Number Publication Date
AR037415A1 true AR037415A1 (en) 2004-11-10

Family

ID=26654105

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020104508A AR037415A1 (en) 2001-11-23 2002-11-22 METHOD TO PRODUCE L-AMINO ACIDS USING BACTERIA THAT BELONG TO THE GENERO ESCHERICHIA

Country Status (14)

Country Link
US (2) US7666655B2 (en)
EP (1) EP1449918B1 (en)
JP (1) JP4305184B2 (en)
KR (1) KR101023925B1 (en)
CN (2) CN1615359B (en)
AR (1) AR037415A1 (en)
AT (1) ATE470711T1 (en)
AU (1) AU2002355022B2 (en)
BR (1) BRPI0214330B1 (en)
CA (1) CA2468179C (en)
DE (1) DE60236684D1 (en)
MX (1) MXPA04004874A (en)
PL (1) PL207852B1 (en)
WO (1) WO2003044192A1 (en)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2229513C2 (en) * 2001-11-23 2004-05-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Method for preparing l-amino acids, strain escherichia coli as producer of l-amino acids (variants)
RU2268300C2 (en) * 2003-04-07 2006-01-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" METHOD FOR PREPARING L-AMINO ACIDS BY USING MICROORGANISMS POSSESSING ENHANCED EXPRESSION OF pckA GENE
BRPI0506369B1 (en) 2004-01-30 2020-11-03 Ajinomoto Co., Inc transgenic microorganism, and, method to produce a l-amino acid
US20050181488A1 (en) * 2004-02-12 2005-08-18 Akhverdian Valery Z. Method for producing L-threonine using bacteria belonging to the genus Escherichia
US20050191684A1 (en) * 2004-02-25 2005-09-01 Zimenkov Danila V. Method for producing L-amino acids
RU2004105179A (en) * 2004-02-25 2005-08-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) 6-PHOSPHOGLUCONOLACTONASE FROM ESCHERICHIA COLI, DNA FRAGMENT, BACTERIA BELONGING TO THE GENUS ESCHERICHIA, PRODUCER OF L-AMINO ACID, AND METHOD FOR PRODUCING L-AMINO ACID
KR101201687B1 (en) * 2004-02-25 2012-11-15 아지노모토 가부시키가이샤 Method for producing L-amino acids
DE102005018835A1 (en) 2005-04-22 2006-11-02 Degussa Ag Process for the preparation of L-amino acids using improved strains of the family Enterobacteriaceae
DE102005019040A1 (en) 2005-04-23 2006-10-26 Degussa Ag Process for the preparation of L-amino acids using improved strains of the family Enterobacteriaceae
EP1899452B1 (en) * 2005-06-17 2010-10-20 Ajinomoto Co., Inc. A method for producing an l-amino acid using a bacterium of the enterobacteriaceae family with enhanced expression of the fucpikur operon
RU2333950C2 (en) * 2005-12-27 2008-09-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) METHOD OF PRODUCTION OF AROMATIC L-AMINO ACIDS USING BACTERIUM BELONGING TO GENUS Methylophilus
EP1979486B1 (en) 2006-01-30 2013-04-17 Ajinomoto Co., Inc. L-amino acid producing bacterium and method of producing l-amino acid
JP2009118740A (en) 2006-03-03 2009-06-04 Ajinomoto Co Inc Method for producing l-amino acid
EP2351830B1 (en) 2006-03-23 2014-04-23 Ajinomoto Co., Inc. A method for producing an L-amino acid using bacterium of the Enterobacteriaceae family with attenuated expression of a gene coding for small RNA
JP2009165355A (en) 2006-04-28 2009-07-30 Ajinomoto Co Inc L-amino acid-producing microorganism and method for producing l-amino acid
EP2021458A1 (en) 2006-05-23 2009-02-11 Ajinomoto Co., Inc. A method for producing an l-amino acid using a bacterium of the enterobacteriaceae family
RU2006129690A (en) 2006-08-16 2008-02-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) METHOD FOR PRODUCING L-AMINO ACID USING BACTERIA OF THE Enterobacteriaceae FAMILY IN WHICH EXPRESSION OF THE ydiN GENE, ydiB GENE OR THEIR COMBINATION IS DECREASED
RU2355763C2 (en) * 2006-09-13 2009-05-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Mutant acetolactase synthase and method of producing branched l-amino acids
JP2010017082A (en) 2006-10-10 2010-01-28 Ajinomoto Co Inc Method for producing l-amino acid
JP2010017081A (en) * 2006-10-10 2010-01-28 Ajinomoto Co Inc Method for producing l-amino acid
RU2006143864A (en) 2006-12-12 2008-06-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE ENTEROBACTERIACEAE FAMILY IN WHICH THE EXPRESSION OF GENES cynT, cynS, cynX, OR cynR, OR THEIR COMBINATION IS DECREASED
JP2010041920A (en) 2006-12-19 2010-02-25 Ajinomoto Co Inc Method for producing l-amino acid
KR100838036B1 (en) * 2006-12-29 2008-06-12 씨제이제일제당 (주) - - a microorganism producing l-tryptophan having an inactivated yjeo gene and the method for producing l-tryptophan using the same
KR100838037B1 (en) * 2006-12-29 2008-06-12 씨제이제일제당 (주) - - a microorganism producing l-tryptophan having an inactivated entc gene and the method for producing l-tryptophan using the same
CN101627110B (en) 2007-01-22 2014-08-13 味之素株式会社 Microorganism capable of producing l-amino acid, and method for production of l-amino acid
JP2010110216A (en) 2007-02-20 2010-05-20 Ajinomoto Co Inc Method for producing l-amino acid or nucleic acid
JP2010110217A (en) 2007-02-22 2010-05-20 Ajinomoto Co Inc L-amino acid-producing microorganism and method for producing l-amino acid
DE102007051024A1 (en) 2007-03-05 2008-09-11 Evonik Degussa Gmbh Process for the preparation of L-amino acids using strains of the family Enterobacteriaceae
EP2192170B1 (en) 2007-09-04 2017-02-15 Ajinomoto Co., Inc. Amino acid-producing microorganism and method of producing amino acid
JP2011067095A (en) 2008-01-10 2011-04-07 Ajinomoto Co Inc Method for producing target substance by fermentation process
KR20100120663A (en) 2008-01-23 2010-11-16 아지노모토 가부시키가이샤 Method of producing l-amino acid
JP5217780B2 (en) * 2008-02-08 2013-06-19 味の素株式会社 Microorganism producing L-amino acid and method for producing L-amino acid
RU2008105793A (en) 2008-02-19 2009-08-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) METHOD FOR DESIGNING OPERONS CONTAINING TRANSLATION-CONJUGATED GENES, BACTERIA CONTAINING SUCH OPERON, METHOD FOR PRODUCING USEFUL METABOLITIS AND METHOD FOR EXPRESS MONITORING
DE102008040352A1 (en) 2008-07-11 2010-01-14 Evonik Degussa Gmbh Process for the preparation of L-tryptophan using improved strains of the family Enterobacteriaceae
EP2336347B1 (en) 2008-09-08 2017-03-15 Ajinomoto Co., Inc. An l-amino acid-producing microorganism and a method for producing an l-amino acid
BRPI1007069A2 (en) 2009-01-23 2015-08-25 Ajinomoto Kk Method for producing an 1-amino acid.
JPWO2011013707A1 (en) 2009-07-29 2013-01-10 味の素株式会社 Method for producing L-amino acid
JP2012223092A (en) 2009-08-28 2012-11-15 Ajinomoto Co Inc Method for producing l-amino acid
JP2013013329A (en) 2009-11-06 2013-01-24 Ajinomoto Co Inc Method for producing l-amino acid
RU2460793C2 (en) 2010-01-15 2012-09-10 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) Method for producing l-amino acids with use of bacteria of enterobacteriaceae family
JP2013074795A (en) 2010-02-08 2013-04-25 Ajinomoto Co Inc MUTANT rpsA GENE AND METHOD FOR PRODUCING L-AMINO ACID
RU2471868C2 (en) 2010-02-18 2013-01-10 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) Mutant adenylate cyclase, dna coding it, bacteria of enterobacteriaceae family containing said dan and method for preparing l-amino acids
RU2501858C2 (en) 2010-07-21 2013-12-20 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) METHOD FOR OBTAINING L-AMINOACID USING BACTERIUM OF Enterobacteriaceae FAMILY
RU2482188C2 (en) 2010-07-21 2013-05-20 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) METHOD FOR PREPARING L-ARGININE WITH USE OF BACTERIA OF GENUS Escherichia WHEREIN astCADBE OPERON IS INACTIVATED
JP2014036576A (en) 2010-12-10 2014-02-27 Ajinomoto Co Inc Method for producing l-amino acids
RU2011134436A (en) 2011-08-18 2013-10-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") METHOD FOR PRODUCING L-AMINO ACID USING THE ENTEROBACTERIACEAE FAMILY POSSESSING AN INCREASED EXPRESSION OF GENES OF THE CASCADE OF THE FORMATION OF FLAGELLS AND CELL MOBILITY
RU2530171C2 (en) * 2012-02-29 2014-10-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") MUTANT PROTEIN, CODED BY GENE yddG, AND METHOD OF OBTAINING AROMATIC L-AMINO ACIDS WITH APPLICATION OF BACTERIA OF GENUS Escherichia
CN102604882B (en) * 2012-03-31 2013-05-22 福建省麦丹生物集团有限公司 Engineering bacterium for producing L-phenylalanine and application thereof
CN104379729B (en) 2012-07-03 2020-07-21 花王株式会社 Process for producing useful microorganism and target substance
RU2013118637A (en) 2013-04-23 2014-10-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE ENTEROBACTERIACEAE FAMILY IN WHICH THE yjjK GENE IS ADJUSTABLE
RU2013140115A (en) 2013-08-30 2015-03-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE Enterobacteriaceae FAMILY IN WHICH THE EXPRESSION OF THE znuACB GENERAL CLUSTER IS DISORDERED
JP2016192903A (en) 2013-09-17 2016-11-17 味の素株式会社 Method for manufacturing l-amino acid from biomass derived from seaweed
KR101783681B1 (en) 2013-10-02 2017-10-10 아지노모토 가부시키가이샤 Ammonia control apparatus and ammonia control method
RU2013144250A (en) 2013-10-02 2015-04-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE Enterobacteriaceae FAMILY IN WHICH THE EXPRESSION OF A GENE CODING A PHOSPHATE TRANSPORTER IS DECREASED
BR112015005215B1 (en) 2013-10-21 2022-12-13 Ajinomoto Co., Inc METHODS FOR THE PRODUCTION OF AN L-AMINO ACID AND FOR THE PRODUCTION OF L-LYSINE
RU2014105547A (en) * 2014-02-14 2015-08-20 Адзиномото Ко., Инк. METHOD FOR PRODUCING L-AMINO ACIDS USING THE ENTEROBACTERIACEAE FAMILY HAVING A SUPER EXPRESSED GENE yajL
RU2015114955A (en) 2015-04-22 2016-11-10 Аджиномото Ко., Инк. A method of obtaining L-isoleucine using bacteria of the Enterobacteriaceae family in which the cycA gene is overexpressed
RU2015120052A (en) 2015-05-28 2016-12-20 Аджиномото Ко., Инк. A method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family in which gshA gene expression is weakened
CN105316371B (en) * 2015-10-23 2018-08-14 安徽丰原发酵技术工程研究有限公司 A method of for improving tryptophan fermentation yield
WO2017122747A1 (en) 2016-01-12 2017-07-20 Ajinomoto Co., Inc. Method for producing benzaldehyde
CN109121422B (en) 2016-02-25 2021-12-21 味之素株式会社 Method for producing L-amino acids using bacteria of the Enterobacteriaceae family overexpressing genes coding for iron exporters
CN108504613B (en) * 2017-02-27 2021-03-30 四川利尔生物科技有限公司 L-homoserine production strain and construction method and application thereof
JP7066977B2 (en) 2017-04-03 2022-05-16 味の素株式会社 Manufacturing method of L-amino acid
KR101968317B1 (en) * 2018-02-23 2019-04-11 씨제이제일제당 주식회사 Novel L-tryptophan export protein and the method of producing L-tryptophan usingthe same
WO2019225658A1 (en) 2018-05-23 2019-11-28 Ajinomoto Co., Inc. A method of producing the tripeptide gamma-glu-val-gly using enterobacteriaceae
WO2020071538A1 (en) 2018-10-05 2020-04-09 Ajinomoto Co., Inc. Method for producing target substance by bacterial fermentation
KR102325835B1 (en) 2018-12-26 2021-11-12 대상 주식회사 Mutant of Escherichia coli or Mutant of Corynebacterium glutamicum for Producing L-amino acid and Method for Producing L-amino acid Using the Same
WO2020171227A1 (en) 2019-02-22 2020-08-27 Ajinomoto Co., Inc. METHOD FOR PRODUCING L-AMINO ACIDS USING A BACTERIUM BELONGING TO THE FAMILY Enterobacteriaceae HAVING OVEREXPRESSED ydiJ GENE
JP2022526181A (en) 2019-04-05 2022-05-23 味の素株式会社 Method for producing L-amino acid
KR102205717B1 (en) * 2019-04-05 2021-01-22 씨제이제일제당 주식회사 Novel variant of L-tryptophan exporter and the method of producing L-tryptophan using the same
WO2021060438A1 (en) 2019-09-25 2021-04-01 Ajinomoto Co., Inc. Method for producing l-amino acids by bacterial fermentation
JPWO2021085405A1 (en) 2019-10-28 2021-05-06
CN113122562A (en) * 2020-01-16 2021-07-16 南京理工大学 Expression vector of membrane protein YddG and expression and purification method thereof
KR102278000B1 (en) * 2020-03-17 2021-07-15 씨제이제일제당 주식회사 The method of producing L-tryptophan using enhancing the activity of prephenate dehydratase
KR102647745B1 (en) * 2020-05-27 2024-03-14 씨제이제일제당 주식회사 Novel L-tyrosine exporter variant and the method of producing L-tyrosine using the same

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3786039A (en) * 1969-04-30 1974-01-15 Ajinomoto Kk Method of producing alpha-l-aspartyl-l-phenylalanine lower alkyl esters
SU875663A1 (en) 1978-06-30 1982-09-15 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Strains e. coli vniigenetika voltage 334 ru no.6 and vniigenetika voltage 334 no.7 producersof l-treonite and method for preparing them
JPS561890A (en) 1979-06-15 1981-01-10 Ajinomoto Co Inc Preparation of l-phenylalanine by fermentation
JPS5618596A (en) 1979-07-23 1981-02-21 Ajinomoto Co Inc Production of l-lysine through fermentation process
US4371614A (en) 1980-08-22 1983-02-01 Ajinomoto Co., Inc. E.Coli bacteria carrying recombinant plasmids and their use in the fermentative production of L-tryptophan
SU974817A1 (en) 1981-06-16 1990-08-23 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Method of producing l-treonin
US4783403A (en) 1984-02-08 1988-11-08 Kyowa Hakko Kogyo Co., Ltd. Process for producing l-phenylalanine
KR890003681B1 (en) 1987-03-26 1989-09-30 주식회사 미원 Process for preparing l-phenyl-alanine by microorganism
SU1694643A1 (en) 1987-11-26 1991-11-30 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Strain of bacteria escherichia coli - a producer of l-threonine
DE69133587D1 (en) * 1990-11-30 2008-01-03 Ajinomoto Kk Recombinant DNA sequences encoding enzymes free of feedback inhibition, plasmids containing these sequences, transformed microorganisms useful for production of aromatic amino acids, and their methods of preparation by fermentation
DE4232468A1 (en) 1992-09-28 1994-03-31 Consortium Elektrochem Ind Microorganisms for the production of tryptophan and process for their production
DK0643135T3 (en) 1992-11-10 2001-10-15 Ajinomoto Kk DNA encoding aspartokinase III mutants and the use of mutants to produce L-threonine by fermentation
US5354672A (en) 1992-11-24 1994-10-11 Ian Fotheringham Materials and methods for hypersecretion of amino acids
JPH07155184A (en) 1993-12-08 1995-06-20 Ajinomoto Co Inc Production of l-lysine by fermentation method
JP4032441B2 (en) 1995-08-30 2008-01-16 味の素株式会社 Method for producing L-amino acid
GB2304718B (en) 1995-09-05 2000-01-19 Degussa The production of tryptophan by the bacterium escherichia coli
DE19548222A1 (en) 1995-12-22 1997-06-26 Forschungszentrum Juelich Gmbh Process for the microbial production of amino acids through increased activity of export carriers
DE19644566A1 (en) * 1996-10-26 1998-04-30 Forschungszentrum Juelich Gmbh Microbial production of substances from the aromatic metabolism / I
DE19726083A1 (en) 1997-06-19 1998-12-24 Consortium Elektrochem Ind Microorganisms and processes for the fermentative production of L-cysteine, L-cystine, N-acetyl-serine or thiazolidine derivatives
RU2144564C1 (en) * 1998-10-13 2000-01-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Dna fragment rhtb encoding synthesis of protein rhtb that determines resistance of bacterium escherichia coli to l-homoserine and method of l-amino acid producing
RU2148642C1 (en) 1998-12-23 2000-05-10 ЗАО "Научно-исследовательский институт АДЖИНОМОТО-Генетика" (ЗАО "АГРИ") Dna rhtc fragment encoding synthesis of rhtc protein that determines enhanced resistance of bacterium escherichia coli to l-threonine and method of l-amino acid producing
RU2175351C2 (en) * 1998-12-30 2001-10-27 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО "АГРИ") Escherichia coli dna fragment determining enhanced production of l-amino acids (variants) and method of l-amino acid producing
AU2002306849A1 (en) * 2001-03-21 2002-10-08 Elitra Pharmaceuticals, Inc. Identification of essential genes in microorganisms
RU2229513C2 (en) * 2001-11-23 2004-05-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Method for preparing l-amino acids, strain escherichia coli as producer of l-amino acids (variants)
US7256003B2 (en) * 2004-07-13 2007-08-14 The Research Foundation For Mental Hygiene, Inc. Method for differentiation of Alzheimer's Disease into subgroups

Also Published As

Publication number Publication date
AU2002355022A1 (en) 2003-06-10
CN101838628A (en) 2010-09-22
EP1449918B1 (en) 2010-06-09
CN101838628B (en) 2012-06-20
PL207852B1 (en) 2011-02-28
US20030157667A1 (en) 2003-08-21
CN1615359A (en) 2005-05-11
CA2468179C (en) 2013-05-21
PL369471A1 (en) 2005-04-18
AU2002355022B2 (en) 2007-09-20
MXPA04004874A (en) 2004-09-03
BRPI0214330B1 (en) 2015-06-16
BR0214330A (en) 2004-11-03
CN1615359B (en) 2010-04-28
JPWO2003044192A1 (en) 2005-03-24
US20100099153A1 (en) 2010-04-22
JP4305184B2 (en) 2009-07-29
WO2003044192A1 (en) 2003-05-30
KR20050044860A (en) 2005-05-13
US7935506B2 (en) 2011-05-03
ATE470711T1 (en) 2010-06-15
US7666655B2 (en) 2010-02-23
DE60236684D1 (en) 2010-07-22
CA2468179A1 (en) 2003-05-30
EP1449918A1 (en) 2004-08-25
KR101023925B1 (en) 2011-03-22
EP1449918A4 (en) 2005-05-18

Similar Documents

Publication Publication Date Title
AR037415A1 (en) METHOD TO PRODUCE L-AMINO ACIDS USING BACTERIA THAT BELONG TO THE GENERO ESCHERICHIA
AR037583A1 (en) METHOD TO PRODUCE L-AMINO ACIDS USING BACTERIA THAT BELONG TO THE GENERO ESCHERICHIA
ATE547516T1 (en) METHOD FOR PRODUCING L-AMINO ACIDS USING MUTANTS OF THE GLTA GENE CODING FOR CITRATE SYNTHASE
ATE404685T1 (en) METHOD FOR PRODUCING L-AMINO ACIDS USING STRAINS OF THE ENTEROBACTERIACEAE FAMILY IN WHICH THE FRUR GENE HAS BEEN DELETED
RU2006132818A (en) Mutant Acetolactate Synthase and Method for the Production of Branched L-Amino Acids
ATE518951T1 (en) MICROORGANISM OF THE GENUS CORYNEBACTERIUM HAVING ENHANCED L-LYSINE PRODUCTIVITY AND METHOD FOR PRODUCING L-LYSINE THEREFROM
PT1885850E (en) D-psicose production method by d-psicose epimerase
RU2005105292A (en) NEW PEPTIDE-GENERATING ENZYME GENE
DE60225288D1 (en) PROCESS FOR THE PREPARATION OF L-AMINO ACIDS USING TREES FROM THE FAMILY OF THE ENTEROBACTERIACEAE CONTAINING AN ATTENUATED UGPB GENE
AR071232A1 (en) HYBRID PROTEIN USED AS A VACCINE AGAINST SHIGA TOXINS BY E. COLI
DE502006008613D1 (en) Process for the fermentative production of proteins
Kowalczyk et al. Feather-degrading bacteria: their biochemical and genetic characteristics
AR118857A1 (en) MICROORGANISM THAT PRODUCES L-AMINO ACID AND METHOD OF PRODUCTION OF L-AMINO ACID USING THE SAME
Jabalia et al. Applications, challenges and future prospects of proteases: An overview
DE50115438D1 (en) Nucleotide sequences encoding the dapC gene and methods of producing L-lysine
CN101978056B (en) Plasmid vector
ATE458037T1 (en) LARGE-TECHNICALLY SUITABLE MICROORGANISM
RU2015105274A (en) METHOD FOR PRODUCING PROTEINS OF FAMILY CYSTEINE PROTEASES (Triticum aestivum) AND PROTEIN TRITIKAIN-ALPH PROTEIN OBTAINED BY THIS METHOD
HUP0002022A2 (en) Process for the fermentative production of l-amino acids and nucleotide sequences coding for the accda-gene
DK1472347T3 (en) Improved protein expression in Bacillus Subtilis
JPWO2021072298A5 (en)
RU2023125543A (en) MUTATED SPOT PROTEIN AND METHOD FOR PRODUCING L-AMINO ACIDS USING ITS
RU2004105179A (en) 6-PHOSPHOGLUCONOLACTONASE FROM ESCHERICHIA COLI, DNA FRAGMENT, BACTERIA BELONGING TO THE GENUS ESCHERICHIA, PRODUCER OF L-AMINO ACID, AND METHOD FOR PRODUCING L-AMINO ACID
JP2008035786A (en) Cysteine protease inhibitor and use thereof
AU2002342763A1 (en) Process for the preparation of non-aromatic l-amino acids using strains of the enterobacteriaceae family

Legal Events

Date Code Title Description
FG Grant, registration