AR036948A1 - CHEMICAL PROCESS - Google Patents

CHEMICAL PROCESS

Info

Publication number
AR036948A1
AR036948A1 ARP020104017A ARP020104017A AR036948A1 AR 036948 A1 AR036948 A1 AR 036948A1 AR P020104017 A ARP020104017 A AR P020104017A AR P020104017 A ARP020104017 A AR P020104017A AR 036948 A1 AR036948 A1 AR 036948A1
Authority
AR
Argentina
Prior art keywords
general formula
compound
isochromanone
halo
treating
Prior art date
Application number
ARP020104017A
Other languages
Spanish (es)
Original Assignee
Syngenta Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syngenta Ltd filed Critical Syngenta Ltd
Publication of AR036948A1 publication Critical patent/AR036948A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/58—Preparation of carboxylic acid halides
    • C07C51/60—Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/58—Preparation of carboxylic acid halides
    • C07C51/62—Preparation of carboxylic acid halides by reactions not involving the carboxylic acid halide group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Un proceso para la preparación de 3-isocromanona con la fórmula general (1): que comprende hacer reaccionar ácido o-tolilacético con un agente halogenante apropiado para formar un compuesto de la fórmula general (3) donde R es halo, haciendo reaccionar el compuesto de la fórmula general (3) con un agente halogenante apropiado para formar un compuesto de la fórmula general (2) donde X es halo; y (a) tratar un compuesto de fórmula general (2) con una base acuosa hasta un pH entre 7 y 14 seguido de acidificación; o (b) agregar el compuesto de fórmula general (2) sobre agua con la adición simultánea a base para mantener el pH, entre 5 y 8; o (c) tratar el compuesto de fórmula general (2) con agua o ácido acuoso seguido de un ajuste de pH hasta un pH entre 5 y 8. Típicamente ambos R y X son cloro. Las 3-Isocromanona es útil, entre otras cosas, como intermediario en la fabricación de productos agrícolas, especialmente fungicidas del tipo de la estrobilurina.A process for the preparation of 3-isochromanone with the general formula (1): which comprises reacting o-tolylacetic acid with an appropriate halogenating agent to form a compound of the general formula (3) where R is halo, reacting the compound of the general formula (3) with an appropriate halogenating agent to form a compound of the general formula (2) where X is halo; and (a) treating a compound of general formula (2) with an aqueous base to a pH between 7 and 14 followed by acidification; or (b) add the compound of the general formula (2) over water with the simultaneous addition based to maintain the pH, between 5 and 8; or (c) treating the compound of general formula (2) with water or aqueous acid followed by a pH adjustment to a pH between 5 and 8. Typically both R and X are chlorine. 3-Isochromanone is useful, among other things, as an intermediary in the manufacture of agricultural products, especially fungicides of the strobilurin type.

ARP020104017A 2001-10-24 2002-10-23 CHEMICAL PROCESS AR036948A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0125473.9A GB0125473D0 (en) 2001-10-24 2001-10-24 Chemical process

Publications (1)

Publication Number Publication Date
AR036948A1 true AR036948A1 (en) 2004-10-13

Family

ID=9924396

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020104017A AR036948A1 (en) 2001-10-24 2002-10-23 CHEMICAL PROCESS

Country Status (4)

Country Link
AR (1) AR036948A1 (en)
AU (1) AU2002329441A1 (en)
GB (1) GB0125473D0 (en)
WO (1) WO2003035636A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0716997B8 (en) 2006-09-10 2021-05-25 Glycotope Gmbh protein or composition of protein molecules, methods for producing and using it
EP1920781B1 (en) 2006-11-10 2015-03-04 Glycotope GmbH Compositions comprising a core-1 positive microorganism and their use for the treatment or prophylaxis of tumors
WO2013026887A1 (en) 2011-08-22 2013-02-28 Glycotope Gmbh Microorganisms carrying a tumor antigen
CN105061375B (en) * 2015-08-31 2017-05-17 江苏七洲绿色化工股份有限公司 Method for preparing 3-isochromanone
US20210187118A1 (en) 2018-05-18 2021-06-24 Daiichi Sankyo Co., Ltd. Anti-muc1 antibody-drug conjugate
CN115772147B (en) * 2022-12-23 2024-03-22 长沙钰腾新材料有限公司 Synthesis method of 3-isochromone or derivative thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9612623D0 (en) * 1996-06-17 1996-08-21 Zeneca Ltd Chemical process

Also Published As

Publication number Publication date
WO2003035636A3 (en) 2003-10-30
GB0125473D0 (en) 2001-12-12
AU2002329441A1 (en) 2003-05-06
WO2003035636A2 (en) 2003-05-01

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Legal Events

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FA Abandonment or withdrawal