AR034022A1 - Acridinas como estimuladoras de la apoptosis mediada por fas - Google Patents

Acridinas como estimuladoras de la apoptosis mediada por fas

Info

Publication number
AR034022A1
AR034022A1 ARP020100859A ARP020100859A AR034022A1 AR 034022 A1 AR034022 A1 AR 034022A1 AR P020100859 A ARP020100859 A AR P020100859A AR P020100859 A ARP020100859 A AR P020100859A AR 034022 A1 AR034022 A1 AR 034022A1
Authority
AR
Argentina
Prior art keywords
acridines
apoptosis
phas
stimulators
approved
Prior art date
Application number
ARP020100859A
Other languages
English (en)
Original Assignee
Telik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Telik Inc filed Critical Telik Inc
Publication of AR034022A1 publication Critical patent/AR034022A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Las 9-[(3-aminopropil)amino]acridinas optativamente sustituidas estimulan la apoptosis medida por Fas. Estos compuestos, optativamente en forma de estereoisómeros únicos o mezclas de estereoisómeros, o sus sales farmacéuticamente aceptables así como las composiciones que los contienen, son útiles en métodos para tratar enfermedades autoinmunes e hiperplásicas.
ARP020100859A 2001-03-08 2002-03-08 Acridinas como estimuladoras de la apoptosis mediada por fas AR034022A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27453501P 2001-03-08 2001-03-08

Publications (1)

Publication Number Publication Date
AR034022A1 true AR034022A1 (es) 2004-01-21

Family

ID=23048595

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020100859A AR034022A1 (es) 2001-03-08 2002-03-08 Acridinas como estimuladoras de la apoptosis mediada por fas

Country Status (3)

Country Link
US (1) US20020169183A1 (es)
AR (1) AR034022A1 (es)
WO (1) WO2002072096A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1778209B8 (en) * 2004-08-18 2010-06-16 Concordia Pharmaceuticals, Inc. Methods and compositions for oral delivery of fts
US9221760B2 (en) 2011-05-09 2015-12-29 Van Andel Research Institute Autophagy inhibitors
CN107721925B (zh) * 2017-09-12 2020-02-14 上海交通大学 一种新型乙酰胆碱酯酶抑制剂及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ200715A (en) * 1982-05-24 1986-06-11 New Zealand Dev Finance Acridine derivatives and pharmaceutical compositions containing such
RU2024509C1 (ru) * 1991-05-07 1994-12-15 Всероссийский научный центр по безопасности биологически активных веществ Производные 9-аминоакридина или их соли с органическими или неорганическими кислотами, проявляющие психотропную, антиамнестическую и липидрегулирующую активность
US6093725A (en) * 1997-01-06 2000-07-25 Cerus Corporation Frangible compounds for pathogen inactivation
US6187787B1 (en) * 1997-06-16 2001-02-13 Trustees Of Dartmouth College Bis(9-aminoacridine) DNA intercalating agents having antitumor activity
WO1999063981A2 (en) * 1998-06-11 1999-12-16 Cerus Corporation Use of alkylating compounds for inhibiting proliferation of arterial smooth muscle cells
CA2412345A1 (en) * 1999-06-16 2000-12-21 University Of Iowa Research Foundation Antagonism of immunostimulatory cpg-oligonucleotides by 4-aminoquinolines and other weak bases
US6589961B2 (en) * 2000-02-18 2003-07-08 New York Medical College 9-alkylamino-1-nitroacridine derivatives
US6525091B2 (en) * 2001-03-07 2003-02-25 Telik, Inc. Substituted diarylureas as stimulators for Fas-mediated apoptosis

Also Published As

Publication number Publication date
WO2002072096A1 (en) 2002-09-19
US20020169183A1 (en) 2002-11-14

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal