AR029741A1 - USE OF N-SUBSTITUTED HETEROCICLICAL COMPOUNDS FOR THE PREPARATION OF MEDICINES FOR THE PROPHYLAXIS AND THERAPY OF THE BRAIN ISCHEMIA AND THE APOPLEJIA - Google Patents
USE OF N-SUBSTITUTED HETEROCICLICAL COMPOUNDS FOR THE PREPARATION OF MEDICINES FOR THE PROPHYLAXIS AND THERAPY OF THE BRAIN ISCHEMIA AND THE APOPLEJIAInfo
- Publication number
- AR029741A1 AR029741A1 ARP000100036A ARP000100036A AR029741A1 AR 029741 A1 AR029741 A1 AR 029741A1 AR P000100036 A ARP000100036 A AR P000100036A AR P000100036 A ARP000100036 A AR P000100036A AR 029741 A1 AR029741 A1 AR 029741A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- alkyl
- branched
- unbranched
- prophylaxis
- Prior art date
Links
- 201000006474 Brain Ischemia Diseases 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000011321 prophylaxis Methods 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 abstract 2
- MWPLVEDNUUSJAV-UHFFFAOYSA-N anthracene Chemical group C1=CC=CC2=CC3=CC=CC=C3C=C21 MWPLVEDNUUSJAV-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- PQNFLJBBNBOBRQ-UHFFFAOYSA-N indane Chemical compound C1=CC=C2CCCC2=C1 PQNFLJBBNBOBRQ-UHFFFAOYSA-N 0.000 abstract 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000006681 (C2-C10) alkylene group Chemical group 0.000 abstract 1
- FUFZNHHSSMCXCZ-UHFFFAOYSA-N 5-piperidin-4-yl-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole Chemical group FC(F)(F)C1=CC=CC(C=2N=C(ON=2)C2CCNCC2)=C1 FUFZNHHSSMCXCZ-UHFFFAOYSA-N 0.000 abstract 1
- 206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
- 150000001421 N-substituted heterocyclic compounds Chemical class 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 206010008118 cerebral infarction Diseases 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Uso de compuestos heterocíclicos N-sustituidos de formula (1) donde: A representa alquileno C1-10 ramificado o no ramificado, o alquileno C2-10 de cadena recta o ramificada, que por lo menos comprende un grupo Z que está elegido entre O, S, NR8, ciclopropilo, CO2, CHOH, un doble o triple enlace; B representa 4-piperidina, 4-tetrahidro-1,2,3,6-piridina, 4-piperazina o los correspondientes compuestos anulares agrandados por el agregado de un grupo metileno, donde el enlace con A se produce a través de un átomo de N de B; y Ar representa fenilo que, dado el caso, está sustituido por alquilo C1-6 ramificado o no ramificado, O-alquilo C1-6 ramificado o no ramificado, OH, F, Cl, Br, I, trifluorometilo, NR22, CO2R2, ciano o fenilo, tetralina, indano, grupos aromáticos de condensacion superior, como naftaleno que, dado el caso, está sustituido por alquilo C1-4 u O-alquilo C1-4, antraceno o heterociclos aromáticos de 5 o 6 eslabones, de 1 a 2 heteroátomos que, independientemente entre sí, están elegidos entre O y N, que además pueden estar anillados todavía con otros restos aromáticos; la parte cíclica que contiene al Nitrogeno está representada por las estructuras (2) o (3); uno de los dos restos X, Y representa CH2 y el otro NR9; y los sustituyentes R1, R2, R3, R4, R5, R6, R7, R8 y R9 son como se definen en la memoria descriptiva; como también sus sales con ácidos farmacologicamente tolerables, para la profilaxis y la terapia de la isquemia cerebral y la apoplejía.Use of N-substituted heterocyclic compounds of formula (1) wherein: A represents branched or unbranched C1-10 alkylene, or straight or branched C2-10 alkylene, which at least comprises a group Z which is chosen from O, S, NR8, cyclopropyl, CO2, CHOH, a double or triple bond; B represents 4-piperidine, 4-tetrahydro-1,2,3,6-pyridine, 4-piperazine or the corresponding ring compounds enlarged by the addition of a methylene group, where the bond with A occurs through an atom of N of B; and Ar represents phenyl which, if necessary, is substituted by branched or unbranched C1-6 alkyl, branched or unbranched C1-6 alkyl, OH, F, Cl, Br, I, trifluoromethyl, NR22, CO2R2, cyano or phenyl, tetralin, indane, higher condensation aromatic groups, such as naphthalene which, if necessary, is substituted by C1-4 alkyl or C1-4 alkyl, anthracene or aromatic heterocycles of 5 or 6 links, 1 to 2 heteroatoms that, independently of each other, are chosen from O and N, which may also be ringed with other aromatic moieties; the cyclic part containing Nitrogen is represented by structures (2) or (3); one of the two residues X, Y represents CH2 and the other NR9; and the substituents R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the specification; as well as its salts with pharmacologically tolerable acids, for the prophylaxis and therapy of cerebral ischemia and stroke.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19900544A DE19900544A1 (en) | 1999-01-11 | 1999-01-11 | Use of compounds of formula I for the prophylaxis and therapy of cerebral ischemia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR029741A1 true AR029741A1 (en) | 2003-07-16 |
Family
ID=7893835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000100036A AR029741A1 (en) | 1999-01-11 | 2000-01-06 | USE OF N-SUBSTITUTED HETEROCICLICAL COMPOUNDS FOR THE PREPARATION OF MEDICINES FOR THE PROPHYLAXIS AND THERAPY OF THE BRAIN ISCHEMIA AND THE APOPLEJIA |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1140099A1 (en) |
| JP (1) | JP2002534467A (en) |
| KR (1) | KR20010101440A (en) |
| CN (1) | CN1333685A (en) |
| AR (1) | AR029741A1 (en) |
| AU (1) | AU2285100A (en) |
| BG (1) | BG105688A (en) |
| BR (1) | BR9916888A (en) |
| CA (1) | CA2359390A1 (en) |
| DE (1) | DE19900544A1 (en) |
| HU (1) | HUP0200520A3 (en) |
| IL (1) | IL144145A0 (en) |
| MX (1) | MXPA01006966A (en) |
| NO (1) | NO20013408L (en) |
| PL (1) | PL348916A1 (en) |
| SK (1) | SK9682001A3 (en) |
| TR (1) | TR200102009T2 (en) |
| WO (1) | WO2000041697A1 (en) |
| ZA (1) | ZA200105473B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004041210A2 (en) | 2002-11-05 | 2004-05-21 | Smithkline Beecham Corporation | Antibacterial agents |
| CA2539479C (en) * | 2003-09-23 | 2010-07-06 | Merck & Co., Inc. | Isoquinoline potassium channel inhibitors |
| EP1939189A4 (en) * | 2005-08-26 | 2013-03-13 | Shionogi & Co | Derivative having ppar agonistic activity |
| MX2010002890A (en) * | 2007-09-20 | 2010-07-02 | Cortex Pharma Inc | 3-substituted 1,2,3-triazin-4-one's and 3-substituted 1,3-pyrimidinone's for enhancing glutamatergic synaptic responses. |
| MA41168A (en) | 2014-12-17 | 2017-10-24 | Acraf | NEW ANTIBACTERIAL COMPOUNDS |
| CN108484594B (en) * | 2018-02-09 | 2020-08-04 | 福建医科大学 | Alkoxy substituted tetrahydropyridopyrimidine compound or available salt thereof, and preparation method and application thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3620643A1 (en) * | 1985-06-22 | 1987-01-22 | Sandoz Ag | Thiazoles, their preparation and use |
| DE3831888A1 (en) * | 1988-09-20 | 1990-03-29 | Troponwerke Gmbh & Co Kg | MEDICINES FOR TREATING APOPLEXIA CEREBRI |
| JP3036789B2 (en) * | 1990-06-22 | 2000-04-24 | 三井化学株式会社 | Novel heterocyclic compounds and pharmaceutical compositions |
| DE19746612A1 (en) * | 1997-10-22 | 1999-04-29 | Basf Ag | New 2-substituted 1,2-benzisothiazole derivatives |
| DE19747063A1 (en) * | 1997-10-24 | 1999-04-29 | Basf Ag | New 3-substituted tetrahydropyridopyrimidinone derivatives |
-
1999
- 1999-01-11 DE DE19900544A patent/DE19900544A1/en not_active Withdrawn
- 1999-12-22 PL PL99348916A patent/PL348916A1/en not_active Application Discontinuation
- 1999-12-22 AU AU22851/00A patent/AU2285100A/en not_active Abandoned
- 1999-12-22 TR TR2001/02009T patent/TR200102009T2/en unknown
- 1999-12-22 HU HU0200520A patent/HUP0200520A3/en unknown
- 1999-12-22 WO PCT/EP1999/010275 patent/WO2000041697A1/en not_active Application Discontinuation
- 1999-12-22 MX MXPA01006966A patent/MXPA01006966A/en unknown
- 1999-12-22 SK SK968-2001A patent/SK9682001A3/en unknown
- 1999-12-22 EP EP99966990A patent/EP1140099A1/en not_active Withdrawn
- 1999-12-22 CN CN99815452A patent/CN1333685A/en active Pending
- 1999-12-22 BR BR9916888-0A patent/BR9916888A/en not_active IP Right Cessation
- 1999-12-22 KR KR1020017008690A patent/KR20010101440A/en not_active Application Discontinuation
- 1999-12-22 IL IL14414599A patent/IL144145A0/en unknown
- 1999-12-22 CA CA002359390A patent/CA2359390A1/en not_active Abandoned
- 1999-12-22 JP JP2000593308A patent/JP2002534467A/en active Pending
-
2000
- 2000-01-06 AR ARP000100036A patent/AR029741A1/en unknown
-
2001
- 2001-07-03 ZA ZA200105473A patent/ZA200105473B/en unknown
- 2001-07-10 NO NO20013408A patent/NO20013408L/en not_active Application Discontinuation
- 2001-07-10 BG BG105688A patent/BG105688A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20013408D0 (en) | 2001-07-10 |
| PL348916A1 (en) | 2002-06-17 |
| SK9682001A3 (en) | 2002-03-05 |
| HUP0200520A2 (en) | 2002-07-29 |
| HUP0200520A3 (en) | 2003-04-28 |
| DE19900544A1 (en) | 2000-07-13 |
| BR9916888A (en) | 2001-11-20 |
| IL144145A0 (en) | 2002-05-23 |
| JP2002534467A (en) | 2002-10-15 |
| BG105688A (en) | 2002-02-28 |
| WO2000041697A1 (en) | 2000-07-20 |
| CA2359390A1 (en) | 2000-07-20 |
| ZA200105473B (en) | 2002-10-03 |
| KR20010101440A (en) | 2001-11-14 |
| NO20013408L (en) | 2001-08-21 |
| MXPA01006966A (en) | 2002-04-10 |
| EP1140099A1 (en) | 2001-10-10 |
| AU2285100A (en) | 2000-08-01 |
| TR200102009T2 (en) | 2002-01-21 |
| CN1333685A (en) | 2002-01-30 |
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