AR028775A1 - DERIVATIVES OF PYRIMIDINE AND ITS USE FOR PROFILAXIS AND THERAPY OF CEREBRAL ISCHEMIA - Google Patents

DERIVATIVES OF PYRIMIDINE AND ITS USE FOR PROFILAXIS AND THERAPY OF CEREBRAL ISCHEMIA

Info

Publication number
AR028775A1
AR028775A1 ARP010103153A ARP010103153A AR028775A1 AR 028775 A1 AR028775 A1 AR 028775A1 AR P010103153 A ARP010103153 A AR P010103153A AR P010103153 A ARP010103153 A AR P010103153A AR 028775 A1 AR028775 A1 AR 028775A1
Authority
AR
Argentina
Prior art keywords
therapy
cerebral ischemia
profilaxis
pyrimidine
derivatives
Prior art date
Application number
ARP010103153A
Other languages
Spanish (es)
Original Assignee
Knoll Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll Ag filed Critical Knoll Ag
Publication of AR028775A1 publication Critical patent/AR028775A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Un derivado 3-sustituido de 5,6,7,8-tetrahidropirido [4,3:4,5]tieno[2,3-d]pirimidin-4(3H)-ona de la formula (1), donde R1 es hidrogeno o alquilo C1-4, y las sales fisiologicamente toleradas de ellos. Uso de los compuestos de formula (1) para producir drogas para la profilaxis y la terapia de la neurodegeneracion, el trauma cerebral y la isquemia cerebral, en particular el ataque apoplético, y de las secuelas ocasionadas por estas enfermedades.A 3-substituted derivative of 5,6,7,8-tetrahydropyrid [4,3: 4,5] thieno [2,3-d] pyrimidin-4 (3H) -one of the formula (1), wherein R1 is hydrogen or C1-4 alkyl, and the physiologically tolerated salts thereof. Use of the compounds of formula (1) to produce drugs for the prophylaxis and therapy of neurodegeneration, brain trauma and cerebral ischemia, in particular apopletic attack, and the sequelae caused by these diseases.

ARP010103153A 2000-07-03 2001-07-02 DERIVATIVES OF PYRIMIDINE AND ITS USE FOR PROFILAXIS AND THERAPY OF CEREBRAL ISCHEMIA AR028775A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10031389A DE10031389A1 (en) 2000-07-03 2000-07-03 Pyrimidine derivatives and their use for the prophylaxis and therapy of cerebral ischemia

Publications (1)

Publication Number Publication Date
AR028775A1 true AR028775A1 (en) 2003-05-21

Family

ID=7647038

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010103153A AR028775A1 (en) 2000-07-03 2001-07-02 DERIVATIVES OF PYRIMIDINE AND ITS USE FOR PROFILAXIS AND THERAPY OF CEREBRAL ISCHEMIA

Country Status (4)

Country Link
AR (1) AR028775A1 (en)
AU (1) AU2001287578A1 (en)
DE (1) DE10031389A1 (en)
WO (1) WO2002002569A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60335536D1 (en) * 2002-04-19 2011-02-10 Bristol Myers Squibb Co METHOD FOR DETECTING OR MODULATING THE INTERACTION OF A CYTOKINE RECEPTOR WITH ITS LIGAND

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19636769A1 (en) * 1996-09-10 1998-03-12 Basf Ag 3-Substituted pyrido [4 ', 3': 4,5] thieno [2,3-d] pyrimidine derivatives, their preparation and use
DE19724980A1 (en) * 1997-06-13 1998-12-17 Basf Ag 3-Substituted 3,4-dihydro-thieno [2,3-d] pyrimidine derivatives, their preparation and use
DE19724979A1 (en) * 1997-06-13 1998-12-17 Basf Ag 3-Substituted pyrido [3,4,5] thieno [2,3-d] pyrimidine derivatives, their preparation and use
US5960613A (en) * 1997-08-28 1999-10-05 Murray, Inc. Ride-on mower having bag-full indicator
DE19900545A1 (en) * 1999-01-11 2000-07-13 Basf Ag Use of pyrimidine derivatives for the prophylaxis and therapy of cerebral ischemia
DE19900673A1 (en) * 1999-01-11 2000-07-13 Basf Ag Use of binding partners for 5-HT5 receptors for the treatment of neurodegenerative and neuropsychiatric disorders

Also Published As

Publication number Publication date
DE10031389A1 (en) 2002-01-17
WO2002002569A1 (en) 2002-01-10
AU2001287578A1 (en) 2002-01-14

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