AR025318A1 - Una nueva asociacion medicamentosa de liberacion programada - Google Patents
Una nueva asociacion medicamentosa de liberacion programadaInfo
- Publication number
- AR025318A1 AR025318A1 ARP000104271A ARP000104271A AR025318A1 AR 025318 A1 AR025318 A1 AR 025318A1 AR P000104271 A ARP000104271 A AR P000104271A AR P000104271 A ARP000104271 A AR P000104271A AR 025318 A1 AR025318 A1 AR 025318A1
- Authority
- AR
- Argentina
- Prior art keywords
- mononitrate
- isossorbide
- acetylsalicylic acid
- vascular
- multiparticulate
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente se relaciona con composiciones farmacéuticas para uso oral y los procesos de obtencion de las mismas. Particularmente, composiciones conaplicacion en la terapia/profilaxia de enfermedades cardiovasculares y/o de sus senales/síntomascomo, por ejemplo, angina péctoris,infarto de miocardio uotras enfermedades vasculares cardíacas, cerebrales o periféricas. Más específicamente, el invento se relaciona con formulaciones combinadas de ácidoacetilsalicílico -un eficaz agenteantiinflamator io, analgésico e antipirético, ampliamente utilizado para el tratamiento de la artritis reumatoide oosteoartritis- y 5-mononitrato de isossorbida, en el que 5-mononitrato de isossorbida es vehiculado en formas multiparticuladas deliberacion programa da y elácido acetilsalicílico vehiculado en forma multiparticulada análoga a la del 5-mononitrato de isossorbida o en formulacion de liberacion normal, aisladamente,en forma de gránulos o también bajo la forma de cristalesrevestidos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR9905261-0A BR9905261A (pt) | 1999-09-30 | 1999-09-30 | Uma nova associação medicamentosa de liberação programada |
Publications (1)
Publication Number | Publication Date |
---|---|
AR025318A1 true AR025318A1 (es) | 2002-11-20 |
Family
ID=4073907
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000104271A AR025318A1 (es) | 1999-09-30 | 2000-08-17 | Una nueva asociacion medicamentosa de liberacion programada |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1088554B1 (es) |
JP (1) | JP2001139469A (es) |
AR (1) | AR025318A1 (es) |
AT (1) | ATE254466T1 (es) |
BR (1) | BR9905261A (es) |
DE (1) | DE60006625D1 (es) |
UY (1) | UY26356A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2380937A (en) * | 2001-10-18 | 2003-04-23 | David Ian Slovick | Method of dispensing a plurality of medical substances into capsules |
US20040029959A1 (en) * | 2002-08-08 | 2004-02-12 | John Devane | Isosorbide mononitrate compositions and methods of their use |
CN104644589B (zh) * | 2015-03-12 | 2017-11-21 | 王加峰 | 一种单硝酸异山梨酯缓释片及其制备工艺 |
CN105902509B (zh) * | 2015-09-28 | 2018-08-17 | 天方药业有限公司 | 一种复方单硝酸异山梨酯缓释片及其制备方法 |
CN110151732A (zh) * | 2019-07-05 | 2019-08-23 | 华裕(无锡)制药有限公司 | 单硝酸异山梨酯缓释胶囊的制备方法 |
CN114456187A (zh) * | 2020-11-09 | 2022-05-10 | 鲁南制药集团股份有限公司 | 单硝酸异山梨酯棒状晶体及其制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5665766A (en) * | 1992-07-30 | 1997-09-09 | Cal International Limited | Ester of an organic nitrate and a salicylate |
WO1998005306A1 (en) * | 1996-08-02 | 1998-02-12 | Cal International Limited | Controlled release tablet formulation of isosorbide-5-mononitrate |
GB9713549D0 (en) * | 1996-10-18 | 1997-09-03 | Euro Celtique Sa | Pharmaceutical combination formulation |
-
1999
- 1999-09-30 BR BR9905261-0A patent/BR9905261A/pt not_active Application Discontinuation
-
2000
- 2000-08-17 AR ARP000104271A patent/AR025318A1/es not_active Application Discontinuation
- 2000-09-26 UY UY26356A patent/UY26356A1/es not_active Application Discontinuation
- 2000-09-28 JP JP2000297275A patent/JP2001139469A/ja active Pending
- 2000-09-29 EP EP00121143A patent/EP1088554B1/en not_active Expired - Lifetime
- 2000-09-29 AT AT00121143T patent/ATE254466T1/de not_active IP Right Cessation
- 2000-09-29 DE DE60006625T patent/DE60006625D1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2001139469A (ja) | 2001-05-22 |
BR9905261A (pt) | 2001-07-24 |
EP1088554B1 (en) | 2003-11-19 |
ATE254466T1 (de) | 2003-12-15 |
DE60006625D1 (de) | 2003-12-24 |
EP1088554A1 (en) | 2001-04-04 |
UY26356A1 (es) | 2000-10-31 |
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Legal Events
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