La composicion terapéutica consiste en un inhibidor de ciclo-oxigenasa-2 o una sal farmacéuticamente aceptable o derivado del mismo y su uso para prevenirla afeccion cardiovascular relacionada con la inflamacion en un individuo que necesita taltrata miento, composicion que es seleccionada entre meloxicam,nimesulida, MK-966, L-783003, T-614, D-1367, L-748731, , CT3, CGP-28238, BF-389, GR-253035, ácido (E)-4-(1,3BIS(ciclohexilmetil)-1,2,3,6-tetrahidro-2,6-dioxo-9H-purin-8-il)cinámico, L-745337 y c ompuestos de formula 1: donde A es un sustituyente seleccionado a partir de anillos heterocíclicos parcialmente insaturadoso insaturados y carbocíclicos parcialmente insaturados o insaturados; donde R1 es como mínimo un sustituyenteseleccionado a pa rtir de heterociclo,cicloalquilo, cicloalquenilo y arilo, donde R1 es opcionalmente sustituido en una posicion sustituible con uno o más radicales seleccionados entre alquilohaloalquilo, ciano, carboxilo, alcoxicarbonilo,hidroxilo, hidroxialquilo, h aloalcoxi, amino, alquilamino, arilamino, nitro, alcoxialquilo, alquilsulfinilo,halo, alcoxi y alquiltio, donde R2 es metilo o amino; y donde R3 es un radical seleccionado a partir de hidruro, halo, alquilo, alquenilo,alquinilo, oxo,ciano, carboxilo , cianoalquilo, heterocicliloxi, alquiloxi, alquiltio, alquilcarbonilo, cicloalquilo, arilo, haloalquilo, heterociclilo cicloalquenilo,aralquilo, heterociclilalquilo, acilo, alquiltioalquilo, hidroxialquilo,alcoxicarbonilo, arilcarbonilo, aralquilca rbonilo, aralquenilo, alcoxialquilo,ariltioalquilo, ariloxialquilo, aralquiltioalquilo, aralcoxialquilo, aralcoxialquilo, alcoxiaralcoxialquilo, alcoxicarbonilalquilo, aminocarbonilo,aminocarbonilalquilo,alquilaminocarbonilo, N-arilaminocarbonilo, N -alquil-N-arilaminocarbonilo, alquilaminocarbonilalquilo, carboxialquilo, alquilamino,N-arilamino, N-aralquilamino, N-alquil-N-aralquilamino, Nalquil-N-arilamino, aminoalquilo, alquilaminoalquilo, N-arilaminoalquilo, N-aralquilaminoalquilo,N-alquil-N -aralquilaminoalquilo, N-alquil-N-arilaminoalquilo, ariloxi, aralcoxi, ariltio, aralquiltio, alquilsulfinilo, alquilsulfonilo, aminosulfonilo,The therapeutic composition consists of a cyclo-oxygenase-2 inhibitor or a pharmaceutically acceptable salt or derivative thereof and its use to prevent cardiovascular disease related to inflammation in an individual in need of taltering, composition that is selected from meloxicam, nimesulide, MK-966, L-783003, T-614, D-1367, L-748731,, CT3, CGP-28238, BF-389, GR-253035, acid (E) -4- (1,3BIS (cyclohexylmethyl) - 1,2,3,6-tetrahydro-2,6-dioxo-9H-purin-8-yl) cinnamic, L-745337 and c formula 2: where A is a substituent selected from partially unsaturated heterocyclic rings unsaturated and partially unsaturated or unsaturated carbocyclics; where R1 is at least one substituent selected from heterocycle, cycloalkyl, cycloalkenyl and aryl, where R1 is optionally substituted in a substitutable position with one or more radicals selected from alkylhaloalkyl, cyano, carboxyl, alkoxycarbonyl, hydroxyl, hydroxyalkyl, h aloalkoxy, amino, alkylamino, arylamino, nitro, alkoxyalkyl, alkylsulfinyl, halo, alkoxy and alkylthio, where R2 is methyl or amino; and where R3 is a radical selected from hydride, halo, alkyl, alkenyl, alkynyl, oxo, cyano, carboxyl, cyanoalkyl, heterocyclyloxy, alkyloxy, alkylthio, alkylcarbonyl, cycloalkyl, aryl, haloalkyl, heterocyclyl cycloalkenyl, aralkyl, heterocyclyl, heterocyclyl, heterocyclyl, heterocyclyl , alkylthioalkyl, hydroxyalkyl, alkoxycarbonyl, arylcarbonyl, rbonilo aralquilca, aralkenyl, alkoxyalkyl, arylthioalkyl, aryloxyalkyl, aralkylthioalkyl, aralkoxyalkyl, aralkoxyalkyl, alkoxyaralkoxyalkyl, alkoxycarbonylalkyl, aminocarbonyl, aminocarbonyl, alkylaminocarbonyl, N-arylaminocarbonyl, N-alkyl-N-arylaminocarbonyl, alkylaminocarbonylalkyl, carboxyalkyl, alkylamino, N-arylamino, N-aralkylamino, N-alkyl-N-aralkylamino, Nalkyl-N-arylamino, aminoalkyl, alkylaminoalkyl, N-arylaminoalkyl, N-aralkylaminoalkyl, N-alkyl-N-aralkylaminoalkyl, N-alkyl- N-arylaminoalkyl, aryloxy, aralkoxy, arylthio, aralkylthio, alkylsulfinyl, alkylsulfonyl, aminos ulfonil,