AR018908A1 - PIRAZOL [3,4-D] PIRIMIDINE COMPOUNDS THAT HAVE AFFINITY FOR ADENOSINE RECEPTORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THAT HAVE ANTI-CONVERSIONING AND ANTI-ALLERGIC / ANTIASMATIC EFFECT, PROCESSING OF DIFFERENT COMPOSITION AND PROCESSING - Google Patents

PIRAZOL [3,4-D] PIRIMIDINE COMPOUNDS THAT HAVE AFFINITY FOR ADENOSINE RECEPTORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THAT HAVE ANTI-CONVERSIONING AND ANTI-ALLERGIC / ANTIASMATIC EFFECT, PROCESSING OF DIFFERENT COMPOSITION AND PROCESSING

Info

Publication number
AR018908A1
AR018908A1 ARP990102974A ARP990102974A AR018908A1 AR 018908 A1 AR018908 A1 AR 018908A1 AR P990102974 A ARP990102974 A AR P990102974A AR P990102974 A ARP990102974 A AR P990102974A AR 018908 A1 AR018908 A1 AR 018908A1
Authority
AR
Argentina
Prior art keywords
compounds
processing
allergic
antiasmatic
pirazol
Prior art date
Application number
ARP990102974A
Other languages
Spanish (es)
Original Assignee
Dresden Arzneimittel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19827679A external-priority patent/DE19827679A1/en
Application filed by Dresden Arzneimittel filed Critical Dresden Arzneimittel
Publication of AR018908A1 publication Critical patent/AR018908A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se trata de compuestos de pirazol [3,4-d]pirimidin-4(5H)-onas y pirazol[3,4-d]pirimidin-4(5H)-tionas y sus tautomeros, que en posicion 2 contienen un restobencilo, también se propone un procedimiento para su elaboracion y la utilizacion de dichoscom puestos para la preparacion de formas, como también deenfermedades alérgicas/asmáticas, tales como asma bronquial, rinoconjuntivitis, alergia o dermatitis atopica. Dichos compuestos responden a la formula donde Xes azufre u oxígeno, Y es halo,alqui lo (C1-4), -CF3, o C1-4 alcoxi. Los compuetos I poseen propiedades farmacologicas mejoradas con respecto a losanticonvulsionantes y antialérgicos conocidos.These are compounds of pyrazol [3,4-d] pyrimidin-4 (5H) -onas and pyrazol [3,4-d] pyrimidin-4 (5H) -thiones and their tautomers, which in position 2 contain a benzyl moiety, A procedure is also proposed for its preparation and the use of such compounds for the preparation of forms, as well as allergic / asthmatic diseases, such as bronchial asthma, rhinoconjunctivitis, allergy or atopic dermatitis. Said compounds respond to the formula where X is sulfur or oxygen, Y is halo, (C1-4) alkyl, -CF3, or C1-4 alkoxy. The compounds I have improved pharmacological properties with respect to known anticonvulsants and antiallergics.

ARP990102974A 1998-06-22 1999-06-22 PIRAZOL [3,4-D] PIRIMIDINE COMPOUNDS THAT HAVE AFFINITY FOR ADENOSINE RECEPTORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THAT HAVE ANTI-CONVERSIONING AND ANTI-ALLERGIC / ANTIASMATIC EFFECT, PROCESSING OF DIFFERENT COMPOSITION AND PROCESSING AR018908A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19827679A DE19827679A1 (en) 1998-06-22 1998-06-22 New pyrazolo(3,4-d)pyrimidine derivative adenosine A3 receptor antagonists, used for treating epilepsy, asthma or allergy

Publications (1)

Publication Number Publication Date
AR018908A1 true AR018908A1 (en) 2001-12-12

Family

ID=40956502

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990102974A AR018908A1 (en) 1998-06-22 1999-06-22 PIRAZOL [3,4-D] PIRIMIDINE COMPOUNDS THAT HAVE AFFINITY FOR ADENOSINE RECEPTORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THAT HAVE ANTI-CONVERSIONING AND ANTI-ALLERGIC / ANTIASMATIC EFFECT, PROCESSING OF DIFFERENT COMPOSITION AND PROCESSING

Country Status (3)

Country Link
KR (1) KR100350823B1 (en)
AR (1) AR018908A1 (en)
CO (1) CO5241271A1 (en)

Also Published As

Publication number Publication date
KR20010023124A (en) 2001-03-26
CO5241271A1 (en) 2003-01-31
KR100350823B1 (en) 2002-08-29

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