AR015621A1 - DERIVATIVES OF 1-THIOGALACTOSE, PHARMACEUTICAL COMPOSITION, TREATMENT METHODS AND SUPPORT CONTAINING SUCH DERIVATIVES - Google Patents
DERIVATIVES OF 1-THIOGALACTOSE, PHARMACEUTICAL COMPOSITION, TREATMENT METHODS AND SUPPORT CONTAINING SUCH DERIVATIVESInfo
- Publication number
- AR015621A1 AR015621A1 ARP980102031A ARP980102031A AR015621A1 AR 015621 A1 AR015621 A1 AR 015621A1 AR P980102031 A ARP980102031 A AR P980102031A AR P980102031 A ARP980102031 A AR P980102031A AR 015621 A1 AR015621 A1 AR 015621A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- alkyl
- cycloalkenyl
- derivatives
- hydrogen
- Prior art date
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Derivados de 1-tiogalactosa que inhiben el enlace de toxinas, como enterotoxina lábil por calor o toxina de colera, a sus receptores, ya sea in vitro o invivo de la formula (I) en donde: R1 es seleccionado del grupo que consiste de hidrogeno, alquilo, alquilo sustituido, alquenilo, alcarilo, alcoxialquilo,arilo, ciclalquilo, cicloalquenilo, heteroarilo, heterocíclico y tioalcoxialquilo,; R2 es seleccionado del grupo que consiste de hidrogeno, alquilo, alquilosustituido, alquenilo, alcarilo, alcoxialquilo, arilo, cicloalquilo, cicloalquenilo, heteroarilo, heterocíclico y tioalcoxialquilo; R3 es seleccionado delgrupo que consiste en hidrogeno, alquilo, alquilo sustituido, alquenilo, alcarilo, alcoxialquilo, arilo, cicloalquilo, cicloalquenilo, heteroarilo,heterocíclico y tioalcoxialquilo; o R1 y R2 o R1 y R3, o R2 y R3 o R1 R2 y R3 se pueden unir, junto con los átomos de carbono a los cuales R1 y/o R2 y/o R3están adheridos, para formar un anillo heterocíclico, cicloalquilo o cicloalquenilo; R4 es seleccionado del grupo que consiste de -XR5, -XC(W)R6, -XC(W)XR7, y-C(W)XR8; en donde W es seleccionado del grupo que consiste de oxígeno, azufre y NH; y X y X son cada uno independientemente seleccionados del grupo queconsiste de oxígeno,azufre y -NR9-, en donde R9 es seleccionado del grupo que consiste de hidrogeno y alquilo; o cuando R4 es -XR5 y R5 no es hidrogeno, Xpuede ser además seleccionado del grupo que consiste de -S(O)- y -SO2; R5 es seleccionado del grupo que consiste dehidrogeno, alquilo, alquenilo, alcarilo,alcoxialquilo, arilo, cicloalquilo, cicloalquenilo, heteroarilo, heterocíclico y tioalcoxialquilo, y cuando X es -NR9-, entonces R9 junto con X pueden formarun aminoácido o R5 y R1 o R5 y R2, o R5 y R3 se pueden unir junto con X del grupo -XR5 y los átomos de carbono a los cuales R1 y/o R2 y/o R3 están adheridos,para formar un anillo heterocíclico; R6 es seleccionado del grupo que consiste de alquilo, alquenilo, alcarilo, alcoxialquilo, arilo, cicloalquilo,cicloalquenilo, heteroarilo, heterocíclico y tioalcoxialquilo; o R6 y R1, o R6 y R2, o R6 y R3 se pueden unir, junto con la porcion -XC(W)- del grupo -XC(W)R61-Thiogalactose derivatives that inhibit the binding of toxins, such as heat labile enterotoxin or cholera toxin, to their receptors, either in vitro or invivo of formula (I) where: R1 is selected from the group consisting of hydrogen , alkyl, substituted alkyl, alkenyl, alkaryl, alkoxyalkyl, aryl, cyclolalkyl, cycloalkenyl, heteroaryl, heterocyclic and thioalkoxyalkyl; R2 is selected from the group consisting of hydrogen, alkyl, substituted alkyls, alkenyl, alkaryl, alkoxyalkyl, aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocyclic and thioalkoxyalkyl; R3 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, alkaryl, alkoxyalkyl, aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocyclic and thioalkoxyalkyl; or R1 and R2 or R1 and R3, or R2 and R3 or R1 R2 and R3 can be attached, together with the carbon atoms to which R1 and / or R2 and / or R3 are attached, to form a heterocyclic ring, cycloalkyl or cycloalkenyl; R4 is selected from the group consisting of -XR5, -XC (W) R6, -XC (W) XR7, and-C (W) XR8; wherein W is selected from the group consisting of oxygen, sulfur and NH; and X and X are each independently selected from the group consisting of oxygen, sulfur and -NR9-, wherein R9 is selected from the group consisting of hydrogen and alkyl; or when R4 is -XR5 and R5 is not hydrogen, X can also be selected from the group consisting of -S (O) - and -SO2; R5 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkaryl, alkoxyalkyl, aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocyclic and thioalkoxyalkyl, and when X is -NR9-, then R9 together with X can form an amino acid or R5 and R1 or R5 and R2, or R5 and R3 can be joined together with X of the group -XR5 and the carbon atoms to which R1 and / or R2 and / or R3 are attached, to form a heterocyclic ring; R6 is selected from the group consisting of alkyl, alkenyl, alkaryl, alkoxyalkyl, aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocyclic and thioalkoxyalkyl; or R6 and R1, or R6 and R2, or R6 and R3 can be joined, together with the -XC (W) - portion of the group -XC (W) R6
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/970,384 US5968907A (en) | 1996-11-14 | 1997-11-14 | 1-thiogalactose derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR015621A1 true AR015621A1 (en) | 2001-05-16 |
Family
ID=25516875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980102031A AR015621A1 (en) | 1997-11-14 | 1998-04-30 | DERIVATIVES OF 1-THIOGALACTOSE, PHARMACEUTICAL COMPOSITION, TREATMENT METHODS AND SUPPORT CONTAINING SUCH DERIVATIVES |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR015621A1 (en) |
| TW (1) | TW467917B (en) |
| ZA (1) | ZA983692B (en) |
-
1998
- 1998-04-28 TW TW087106568A patent/TW467917B/en active
- 1998-04-30 ZA ZA983692A patent/ZA983692B/en unknown
- 1998-04-30 AR ARP980102031A patent/AR015621A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA983692B (en) | 1998-11-11 |
| TW467917B (en) | 2001-12-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |