AR015428A1 - DERIVATIVES OF 2- (ARILFENIL) AMINO-IMIDAZOLIDINE, PROCESS FOR PREPARATION, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND USE FOR THE MANUFACTURE OF A MEDICINE - Google Patents

DERIVATIVES OF 2- (ARILFENIL) AMINO-IMIDAZOLIDINE, PROCESS FOR PREPARATION, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND USE FOR THE MANUFACTURE OF A MEDICINE

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Publication number
AR015428A1
AR015428A1 ARP980104390A AR015428A1 AR 015428 A1 AR015428 A1 AR 015428A1 AR P980104390 A ARP980104390 A AR P980104390A AR 015428 A1 AR015428 A1 AR 015428A1
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Argentina
Prior art keywords
integer
alkyl
independently
case
heterocyclyl
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Spanish (es)
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Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR015428A1 publication Critical patent/AR015428A1/en

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Abstract

Derivados de 2-(arilfenil)amino-imidazolidina representados por la formula I en la que R1 es un grupo representado por la formula (A), (B) o (C); en la queX es independientemente en cada caso S, O o N; R2 y R4 son cada uno independientemente en cadacaso: (1) hidrogeno, (2) alquiloxi, o (3) halogeno; R3 esindependientemente en cada caso (1) alquilo, (2) cicloalquilo, (3) halogeno, (4) heterociclilo, (5) -NR8R9, (6) -(CH2)mCONR8R9, donde m es un entero de 0 a 3,(7)-(CH2)mSO2NR8R9, donde m es un entero de 0 a 3;(8) -(CH2)mNR7COR9, donde m es un entero de 0 a 3,(9)-(CH2)mNR7SO2R9,donde m es un entero de 0 a 3,(10)-(CH2)mNR7C(V)NR8R9,donde V es S o O, y m es entero de 0 a 3,(11)-(CH2)mOY,donde m es un entero de 0 a 3 y Y es: hidrogeno, alquilo,alquiloxialquilo, cicloalquilo,haloalquilo,hidroxialquilo, heterociclilo o carboxialquilo o,(12)-O(CH2)nZ,donde n es un entero de 1 a 4 y Z es:cicloalquilo, hidroxialquilo, cicloalquiloxi,heterociclilo,ariloxi, heteroarilo, -COR9,-CONR9R9,-SO2R9,-SO2NR8R9, -NR7SO2R9,o arilo no sustituido, o arilo mono-, di- o tri-sustituido, seleccionándose lossustituyentes independientemente de alquilo, halogeno o alquiloxi; R5 es independientemente en cada caso: (1) -(CH2)mOY, en el que m es un entero de 0 a3 y Yes H, alquilo, alquiloxialquilo, cicloalquilo, haloalquilo, hidroxialquilo, heterociclilo o carboxialquilo, o (2) -O(CH2)nZ en el que n es un entero de 1 a 4 yZ es cicloalquilo, hidroxialquilo, cicloalquiloxi, heterociclilo, ariloxi, heteroarilo, -COR. -CONR8R9, -SO2R9, -SO2NR8R9, -NR7SO2R9, o arilo no sustituido, oarilo mono-, di- o tri-sustituido seleccionándose los sustituyentes independientemente de alquilo, halogeno o alquiloxi; R6 es independientemente en cada caso;(1) hidrogeno, (2)-COR9, (3) -CONR8R9, (4) -C(V)NR8R9, donde V es O o S, (5) -SO2R9, (6) -SO2NR8R9; R7 y R8 son cada uno independientemente en cada caso; (1)hidrogeno, (2) alquilo, o (3) hidroxialquilo; R9 es independientemente en cada caso: (1)alquilo, (2) cicloalquilo, (3) arilalquilo, (4) hidroxialquilo, (5)haloalquilo, (6) heterociclilo, (7) arilo no sustituido, o arilo mono-, di- o tri-sustituido, seleccionándose los sustituyentes independientemente de alquilo,2- (Arylphenyl) amino-imidazolidine derivatives represented by formula I in which R 1 is a group represented by formula (A), (B) or (C); where X is independently in each case S, O or N; R2 and R4 are each independently in each case: (1) hydrogen, (2) alkyloxy, or (3) halogen; R3 is independently in each case (1) alkyl, (2) cycloalkyl, (3) halogen, (4) heterocyclyl, (5) -NR8R9, (6) - (CH2) mCONR8R9, where m is an integer from 0 to 3, (7) - (CH2) mSO2NR8R9, where m is an integer from 0 to 3; (8) - (CH2) mNR7COR9, where m is an integer from 0 to 3, (9) - (CH2) mNR7SO2R9, where m is an integer from 0 to 3, (10) - (CH2) mNR7C (V) NR8R9, where V is S or O, and m is an integer from 0 to 3, (11) - (CH2) mOY, where m is an integer of 0 to 3 and Y is: hydrogen, alkyl, alkyloxyalkyl, cycloalkyl, haloalkyl, hydroxyalkyl, heterocyclyl or carboxyalkyl or, (12) -O (CH2) nZ, where n is an integer from 1 to 4 and Z is: cycloalkyl, hydroxyalkyl , cycloalkyloxy, heterocyclyl, aryloxy, heteroaryl, -COR9, -CONR9R9, -SO2R9, -SO2NR8R9, -NR7SO2R9, or unsubstituted aryl, or mono-, di- or tri-substituted aryl, the substituents being independently selected from alkyl, halogen or alkyloxy ; R5 is independently in each case: (1) - (CH2) mOY, in which m is an integer from 0 to 3 and Yes H, alkyl, alkyloxyalkyl, cycloalkyl, haloalkyl, hydroxyalkyl, heterocyclyl or carboxyalkyl, or (2) -O (CH2) nZ in which n is an integer from 1 to 4 and Z is cycloalkyl, hydroxyalkyl, cycloalkyloxy, heterocyclyl, aryloxy, heteroaryl, -COR. -CONR8R9, -SO2R9, -SO2NR8R9, -NR7SO2R9, or unsubstituted aryl, mono-, di- or tri-substituted oaryl with the substituents independently selected from alkyl, halogen or alkyloxy; R6 is independently in each case; (1) hydrogen, (2) -COR9, (3) -CONR8R9, (4) -C (V) NR8R9, where V is O or S, (5) -SO2R9, (6) -SO2NR8R9; R7 and R8 are each independently in each case; (1) hydrogen, (2) alkyl, or (3) hydroxyalkyl; R9 is independently in each case: (1) alkyl, (2) cycloalkyl, (3) arylalkyl, (4) hydroxyalkyl, (5) haloalkyl, (6) heterocyclyl, (7) unsubstituted aryl, or mono-, di-aryl - or tri-substituted, the substituents being independently selected from alkyl,

ARP980104390 1997-09-04 1998-09-02 DERIVATIVES OF 2- (ARILFENIL) AMINO-IMIDAZOLIDINE, PROCESS FOR PREPARATION, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND USE FOR THE MANUFACTURE OF A MEDICINE AR015428A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5780897P 1997-09-04 1997-09-04

Publications (1)

Publication Number Publication Date
AR015428A1 true AR015428A1 (en) 2001-05-02

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ID=22012881

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980104390 AR015428A1 (en) 1997-09-04 1998-09-02 DERIVATIVES OF 2- (ARILFENIL) AMINO-IMIDAZOLIDINE, PROCESS FOR PREPARATION, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND USE FOR THE MANUFACTURE OF A MEDICINE

Country Status (10)

Country Link
AR (1) AR015428A1 (en)
BR (1) BR9803373A (en)
CO (1) CO4810372A1 (en)
HR (1) HRP980487A2 (en)
ID (1) ID20883A (en)
PE (1) PE107499A1 (en)
PL (1) PL328363A1 (en)
TR (1) TR199801735A2 (en)
YU (1) YU38498A (en)
ZA (1) ZA987925B (en)

Also Published As

Publication number Publication date
CO4810372A1 (en) 1999-06-30
HRP980487A2 (en) 1999-06-30
TR199801735A3 (en) 1999-03-22
ZA987925B (en) 1999-03-04
TR199801735A2 (en) 1999-03-22
PE107499A1 (en) 1999-11-03
ID20883A (en) 1999-03-18
YU38498A (en) 2001-09-28
PL328363A1 (en) 1999-03-15
BR9803373A (en) 2001-04-24

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