AR015164A1 - NEW 1-ARIL-3-HETEROARIL-TIOUREAS REPLACED AND 1-ARIL-3-HETEROARIL-ISOTIOUREAS REPLACED AS ANTIATEROSCLEROTIC AGENTS, ITS USE IN THE MANUFACTURING A MEDICINAL AND PHARMACEUTICAL COMPOSITION CONTAINING THEM - Google Patents

NEW 1-ARIL-3-HETEROARIL-TIOUREAS REPLACED AND 1-ARIL-3-HETEROARIL-ISOTIOUREAS REPLACED AS ANTIATEROSCLEROTIC AGENTS, ITS USE IN THE MANUFACTURING A MEDICINAL AND PHARMACEUTICAL COMPOSITION CONTAINING THEM

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Publication number
AR015164A1
AR015164A1 ARP980104386A ARP980104386A AR015164A1 AR 015164 A1 AR015164 A1 AR 015164A1 AR P980104386 A ARP980104386 A AR P980104386A AR P980104386 A ARP980104386 A AR P980104386A AR 015164 A1 AR015164 A1 AR 015164A1
Authority
AR
Argentina
Prior art keywords
heteroaril
aril
replaced
lower alkyl
pharmaceutical composition
Prior art date
Application number
ARP980104386A
Other languages
Spanish (es)
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of AR015164A1 publication Critical patent/AR015164A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/48—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/84—Naphthothiazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1-aril-3-heteroaril-tioureas e isotioureas sustituidas como agentes antiateroscleroticos que son representados por las formulas (I) o (II) en donde: R esun compuesto seleccionado del grupo (III), en donde R9, R10, R11, R12, R13 y R14 son cada uno, independientemente, hidrogeno o un alquilo inferior C1-6; R6 yR7 son cada uno independientemente, hidrogeno, alquilo inferior C1-6, o CH2COOR8, donde R8 es un alquilo inferior C1-6; y X es O o S; R1 es hidrogeno, o unalquilo inferior C1-6; R2, R3 y R4son cada uno, independientemente, hidrogeno o halogeno; y R5 es un alquilo inferior C1-6; o una sal farmacéuticamenteaceptable de los mismos, su uso para la manufactura de un medicamento utiles para elevar la concentracion de colesterol HDL que pueden ser utiles en eltratamiento de aterosclerosis y condiciones relacionadas, como dislipoproteinemias y enfermedades coronarias del corazon y composicion farmacéutica que lascontiene.1-aryl-3-heteroaryl-thioureas and substituted isothioureas as anti-atherosclerotic agents that are represented by formulas (I) or (II) where: R is a compound selected from group (III), where R9, R10, R11, R12 , R13 and R14 are each independently hydrogen or a C1-6 lower alkyl; R6 and R7 are each independently hydrogen, C1-6 lower alkyl, or CH2COOR8, where R8 is a C1-6 lower alkyl; and X is O or S; R1 is hydrogen, or a C1-6 lower alkyl; R2, R3 and R4 are each independently hydrogen or halogen; and R5 is a C1-6 lower alkyl; or a pharmaceutically acceptable salt thereof, its use for the manufacture of a medicament useful for raising the concentration of HDL cholesterol that may be useful in the treatment of atherosclerosis and related conditions, such as dyslipoproteinemias and coronary heart disease and pharmaceutical composition containing them.

ARP980104386A 1997-09-03 1998-09-02 NEW 1-ARIL-3-HETEROARIL-TIOUREAS REPLACED AND 1-ARIL-3-HETEROARIL-ISOTIOUREAS REPLACED AS ANTIATEROSCLEROTIC AGENTS, ITS USE IN THE MANUFACTURING A MEDICINAL AND PHARMACEUTICAL COMPOSITION CONTAINING THEM AR015164A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92229997A 1997-09-03 1997-09-03

Publications (1)

Publication Number Publication Date
AR015164A1 true AR015164A1 (en) 2001-04-18

Family

ID=25446856

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980104386A AR015164A1 (en) 1997-09-03 1998-09-02 NEW 1-ARIL-3-HETEROARIL-TIOUREAS REPLACED AND 1-ARIL-3-HETEROARIL-ISOTIOUREAS REPLACED AS ANTIATEROSCLEROTIC AGENTS, ITS USE IN THE MANUFACTURING A MEDICINAL AND PHARMACEUTICAL COMPOSITION CONTAINING THEM

Country Status (5)

Country Link
AR (1) AR015164A1 (en)
AU (1) AU8924098A (en)
TW (1) TW415942B (en)
WO (1) WO1999011638A1 (en)
ZA (1) ZA987973B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2744893A1 (en) 2002-06-27 2004-01-08 Novo Nordisk A/S Aryl carbonyl derivatives as glucokinase activators

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2712630A1 (en) * 1977-03-23 1978-09-28 Bayer Ag 1,3,4-THIADIAZOL-2-YL-UREA, METHOD OF MANUFACTURING AND USE AS FUNGICIDES
IL67417A (en) * 1982-01-26 1989-10-31 American Cyanamid Co Antiatherosclerotic substituted ureas,process for their preparation and pharmaceutical compositions containing them
US4623662A (en) * 1985-05-23 1986-11-18 American Cyanamid Company Antiatherosclerotic ureas and thioureas
JPH049375A (en) * 1990-04-25 1992-01-14 Takeda Chem Ind Ltd Thiourea derivative and age generation inhibitor
US5420164A (en) * 1991-04-04 1995-05-30 Yoshitomi Pharmaceutical Industries, Ltd. Cycloalkylurea compounds
US5185358A (en) * 1991-06-24 1993-02-09 Warner-Lambert Co. 3-heteroatom containing urea and thiourea ACAT inhibitors
HUT62558A (en) * 1991-07-01 1993-05-28 Sandoz Ag Process for producing n-phenylthiourea derivaties and pharmaceutical compositions comprising same
NZ250916A (en) * 1993-02-27 1995-08-28 Nihon Nohyaku Co Ltd N-heteroaryl-n'-phenylureas, their use as acat inhibitors
US5547966A (en) * 1993-10-07 1996-08-20 Bristol-Myers Squibb Company Aryl urea and related compounds
DE4438021A1 (en) * 1994-10-25 1996-05-02 Thomae Gmbh Dr K New N-cyclohexyl-N-phenyl-urea cholesterol biosynthesis inhibitors
JPH08301841A (en) * 1995-05-10 1996-11-19 Green Cross Corp:The Squalene-epoxydase activity inhibitor
WO1997019932A1 (en) * 1995-11-28 1997-06-05 American Home Products Corporation 2-thioxo-imidazolidin-4-one derivatives and their use for increasing hdl cholesterol concentration

Also Published As

Publication number Publication date
AU8924098A (en) 1999-03-22
TW415942B (en) 2000-12-21
WO1999011638A1 (en) 1999-03-11
ZA987973B (en) 2000-03-22

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