AR013424A1 - USE OF URIDINE FOR THE PREPARATION OF A USEFUL PHARMACEUTICAL COMPOSITION TO INHIBIT THE TOXICITY OF PIRIMIDINE ANALOGS - Google Patents

USE OF URIDINE FOR THE PREPARATION OF A USEFUL PHARMACEUTICAL COMPOSITION TO INHIBIT THE TOXICITY OF PIRIMIDINE ANALOGS

Info

Publication number
AR013424A1
AR013424A1 ARP980104066A AR013424A1 AR 013424 A1 AR013424 A1 AR 013424A1 AR P980104066 A ARP980104066 A AR P980104066A AR 013424 A1 AR013424 A1 AR 013424A1
Authority
AR
Argentina
Prior art keywords
uridine
tissue
pharmaceutical composition
inhibit
pyrimidine analog
Prior art date
Application number
Other languages
Spanish (es)
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of AR013424A1 publication Critical patent/AR013424A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof

Abstract

Uso de uridina para preparar una composicion farmacéutica util para inhibir la toxicidad inducida por un análogo de pirimidina en un tejido de unpaciente, el cual está siendo sometido a un tratamiento con un análogo de pirimidina. Dichotejido se pone en contacto con una cantidad terapéuticamenteefectiva de uridina en la forma de una composicion farmacéutica. En una forma de realizacion, se describe el uso de la uridina para inhibir la estomatitisinducida por quimioterapia en unpaciente que se somete a un tratamiento con un análogo de pirimidina. El análogo de pirimidina es un agente quimioterapéuticoque induce estomatitis, tal como el 5-fluorouracilo o la 5-fluoro-2- desoxiuridina y el tejido es un tejido intraoral, tal como un tejido mucosooral o un tejido blando intraoral.Use of uridine to prepare a pharmaceutical composition useful for inhibiting toxicity induced by a pyrimidine analog in a patient's tissue, which is undergoing treatment with a pyrimidine analog. Such a tissue is contacted with a therapeutically effective amount of uridine in the form of a pharmaceutical composition. In one embodiment, the use of uridine to inhibit chemotherapy-induced stomatitis in a patient undergoing treatment with a pyrimidine analog is described. The pyrimidine analog is a chemotherapeutic agent that induces stomatitis, such as 5-fluorouracil or 5-fluoro-2-deoxyuridine, and the tissue is an intraoral tissue, such as a mucosooral tissue or an intraoral soft tissue.

ARP980104066 1997-08-21 1998-08-18 USE OF URIDINE FOR THE PREPARATION OF A USEFUL PHARMACEUTICAL COMPOSITION TO INHIBIT THE TOXICITY OF PIRIMIDINE ANALOGS AR013424A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91576997A 1997-08-21 1997-08-21

Publications (1)

Publication Number Publication Date
AR013424A1 true AR013424A1 (en) 2000-12-27

Family

ID=25436223

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980104066 AR013424A1 (en) 1997-08-21 1998-08-18 USE OF URIDINE FOR THE PREPARATION OF A USEFUL PHARMACEUTICAL COMPOSITION TO INHIBIT THE TOXICITY OF PIRIMIDINE ANALOGS

Country Status (4)

Country Link
AR (1) AR013424A1 (en)
AU (1) AU8388198A (en)
HR (1) HRP980436A2 (en)
WO (1) WO1999008686A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE529064C2 (en) * 2005-01-03 2007-04-24 Selectica Pharmaceuticals Ab Topical compositions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2016921B (en) * 1978-03-27 1982-08-18 Taiho Pharmaceutical Co Ltd Anti cancer compositions containing uracil derivatives
US5968914A (en) * 1987-10-28 1999-10-19 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
JPH04503814A (en) * 1989-06-21 1992-07-09 ザ・キャソリック・ユニバーシティー・オブ・アメリカ Antimalarial composition and method of use
AU6081294A (en) * 1993-05-14 1994-12-12 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides

Also Published As

Publication number Publication date
WO1999008686A1 (en) 1999-02-25
HRP980436A2 (en) 1999-04-30
AU8388198A (en) 1999-03-08

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