AR013149A1 - Derivados de (1h-imidazol-4-il)piperidina, su preparacion y su aplicacion en terapeutica - Google Patents
Derivados de (1h-imidazol-4-il)piperidina, su preparacion y su aplicacion en terapeuticaInfo
- Publication number
- AR013149A1 AR013149A1 ARP980103161A ARP980103161A AR013149A1 AR 013149 A1 AR013149 A1 AR 013149A1 AR P980103161 A ARP980103161 A AR P980103161A AR P980103161 A ARP980103161 A AR P980103161A AR 013149 A1 AR013149 A1 AR 013149A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl group
- group
- linear
- branched
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos de la formula (I) en la cual R1 y R2 representan cada uno independientemente del otro, o bien un átomo de hidrogeno, o bien un grupo(C1-4)alquilo, lineal o ramificado, R3 y R4 representana cada uno independientementedel otro ya sea un átomo de hidrogeno o de halogeno, o bienun grupo C1-4 alquilo, o bien un grupo trifluorometilo, C1-4 alcoxi, S(O)pR, con R grupo C1-4 alquilo lineal o ramificado y p = 0 a 2, y A representa o bienun átomo de hidrogeno, o bienun grupo C1-6 alquilo lineal o ramificado, fenil C1-4 alquilo, -COR5, COOR5, -CONHR5, -SO2R5, donde R5 es un grupo C1-6alquilo lineal o ramificado, un grupo C3-7 cicloalquilo, un grupo C3-7 cicloalquilo C1-5 alquilo, un grupo C1-4 alcoxiC1-6 alquilo, un grupo fenilo,un grupo fenil C1-4 alquilo, un grupo fenil C1-4 alquilideno, o bien un grupo -COCH2NR6R7 donde R6 es un átomo de hidrogeno o un grupo C1-4 alquilo linealo ramificado y R7 es un grupo C1-4 alquilo lineal o ramificadoo aci lo o R1, R3 y R4 son tal como se los ha definido anteriormente, A y R2 forman un ciclode tipo -(CH2)nCO- donde n puede tomar un valor comprendido entre 2 y 6, en estado de bases libres o de sales de adicion con ácidosfarmacéuticamenteaceptables. Aplicacion en terapéutica, propiedad inhibidora del cambiador sodio/proton.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9708256A FR2765580B1 (fr) | 1997-07-01 | 1997-07-01 | Derives de (1h-imidazol-4-yl)piperidine, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR013149A1 true AR013149A1 (es) | 2000-12-13 |
Family
ID=9508676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980103161A AR013149A1 (es) | 1997-07-01 | 1998-06-30 | Derivados de (1h-imidazol-4-il)piperidina, su preparacion y su aplicacion en terapeutica |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0994857A1 (es) |
| JP (1) | JP2002507983A (es) |
| AR (1) | AR013149A1 (es) |
| AU (1) | AU8220598A (es) |
| FR (1) | FR2765580B1 (es) |
| WO (1) | WO1999001435A1 (es) |
| ZA (1) | ZA985727B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6887870B1 (en) | 1999-10-12 | 2005-05-03 | Bristol-Myers Squibb Company | Heterocyclic sodium/proton exchange inhibitors and method |
| GB0011089D0 (en) * | 2000-05-08 | 2000-06-28 | Black James Foundation | Gastrin and cholecystokinin receptor ligands (11) |
| TW200614995A (en) | 2004-11-10 | 2006-05-16 | Nicholas Piramal India Ltd | Tricyclic guanidine derivatives as sodium-proton exchange inhibitors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4357341A (en) * | 1981-05-22 | 1982-11-02 | The United States Of America As Represented By The Department Of Health And Human Services | Specific irreversible antagonism of histamine receptors by photoaffinity actuated compounds |
| FR2674855B1 (fr) * | 1991-04-03 | 1994-01-14 | Synthelabo | Derives de piperidine, leur preparation et leur application en therapeutique. |
-
1997
- 1997-07-01 FR FR9708256A patent/FR2765580B1/fr not_active Expired - Fee Related
-
1998
- 1998-06-19 AU AU82205/98A patent/AU8220598A/en not_active Abandoned
- 1998-06-19 JP JP50651199A patent/JP2002507983A/ja active Pending
- 1998-06-19 WO PCT/FR1998/001287 patent/WO1999001435A1/fr not_active Application Discontinuation
- 1998-06-19 EP EP98932236A patent/EP0994857A1/fr not_active Withdrawn
- 1998-06-30 AR ARP980103161A patent/AR013149A1/es unknown
- 1998-06-30 ZA ZA985727A patent/ZA985727B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0994857A1 (fr) | 2000-04-26 |
| FR2765580A1 (fr) | 1999-01-08 |
| WO1999001435A1 (fr) | 1999-01-14 |
| JP2002507983A (ja) | 2002-03-12 |
| FR2765580B1 (fr) | 1999-08-06 |
| AU8220598A (en) | 1999-01-25 |
| ZA985727B (en) | 1999-01-27 |
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