AR013149A1 - DERIVATIVES OF (1H-IMIDAZOL-4-IL) PIPERIDINE, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS - Google Patents

DERIVATIVES OF (1H-IMIDAZOL-4-IL) PIPERIDINE, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS

Info

Publication number
AR013149A1
AR013149A1 ARP980103161A ARP980103161A AR013149A1 AR 013149 A1 AR013149 A1 AR 013149A1 AR P980103161 A ARP980103161 A AR P980103161A AR P980103161 A ARP980103161 A AR P980103161A AR 013149 A1 AR013149 A1 AR 013149A1
Authority
AR
Argentina
Prior art keywords
alkyl group
group
linear
branched
phenyl
Prior art date
Application number
ARP980103161A
Other languages
Spanish (es)
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of AR013149A1 publication Critical patent/AR013149A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compuestos de la formula (I) en la cual R1 y R2 representan cada uno independientemente del otro, o bien un átomo de hidrogeno, o bien un grupo(C1-4)alquilo, lineal o ramificado, R3 y R4 representana cada uno independientementedel otro ya sea un átomo de hidrogeno o de halogeno, o bienun grupo C1-4 alquilo, o bien un grupo trifluorometilo, C1-4 alcoxi, S(O)pR, con R grupo C1-4 alquilo lineal o ramificado y p = 0 a 2, y A representa o bienun átomo de hidrogeno, o bienun grupo C1-6 alquilo lineal o ramificado, fenil C1-4 alquilo, -COR5, COOR5, -CONHR5, -SO2R5, donde R5 es un grupo C1-6alquilo lineal o ramificado, un grupo C3-7 cicloalquilo, un grupo C3-7 cicloalquilo C1-5 alquilo, un grupo C1-4 alcoxiC1-6 alquilo, un grupo fenilo,un grupo fenil C1-4 alquilo, un grupo fenil C1-4 alquilideno, o bien un grupo -COCH2NR6R7 donde R6 es un átomo de hidrogeno o un grupo C1-4 alquilo linealo ramificado y R7 es un grupo C1-4 alquilo lineal o ramificadoo aci lo o R1, R3 y R4 son tal como se los ha definido anteriormente, A y R2 forman un ciclode tipo -(CH2)nCO- donde n puede tomar un valor comprendido entre 2 y 6, en estado de bases libres o de sales de adicion con ácidosfarmacéuticamenteaceptables. Aplicacion en terapéutica, propiedad inhibidora del cambiador sodio/proton.Compounds of formula (I) in which R1 and R2 each represent independently of the other, either a hydrogen atom, or a linear or branched (C1-4) alkyl group, R3 and R4 each represent independently of the other either a hydrogen or halogen atom, or a C1-4 alkyl group, or a trifluoromethyl, C1-4 alkoxy group, S (O) pR, with R C1-4 linear or branched alkyl group and p = 0 to 2 , and A represents either a hydrogen atom, or a C1-6 linear or branched alkyl group, phenyl C1-4 alkyl, -COR5, COOR5, -CONHR5, -SO2R5, where R5 is a linear or branched C1-6alkyl group, a C3-7 cycloalkyl group, a C3-7 cycloalkyl C1-5 alkyl group, a C1-4 alkoxyC1-6 alkyl group, a phenyl group, a phenyl C1-4 alkyl group, or a phenyl C1-4 alkylidene group, or a -COCH2NR6R7 group where R6 is a hydrogen atom or a C1-4 branched linear alkyl group and R7 is a C1-4 linear or branched alkyl group or R1, R3 and R4 are as As previously defined, A and R2 form a cyclode type - (CH2) nCO- where n can take a value between 2 and 6, in the state of free bases or addition salts with pharmaceutically acceptable acids. Therapeutic application, inhibitory property of the sodium / proton exchanger.

ARP980103161A 1997-07-01 1998-06-30 DERIVATIVES OF (1H-IMIDAZOL-4-IL) PIPERIDINE, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS AR013149A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9708256A FR2765580B1 (en) 1997-07-01 1997-07-01 (1H-IMIDAZOL-4-YL) PIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (1)

Publication Number Publication Date
AR013149A1 true AR013149A1 (en) 2000-12-13

Family

ID=9508676

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980103161A AR013149A1 (en) 1997-07-01 1998-06-30 DERIVATIVES OF (1H-IMIDAZOL-4-IL) PIPERIDINE, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS

Country Status (7)

Country Link
EP (1) EP0994857A1 (en)
JP (1) JP2002507983A (en)
AR (1) AR013149A1 (en)
AU (1) AU8220598A (en)
FR (1) FR2765580B1 (en)
WO (1) WO1999001435A1 (en)
ZA (1) ZA985727B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6887870B1 (en) 1999-10-12 2005-05-03 Bristol-Myers Squibb Company Heterocyclic sodium/proton exchange inhibitors and method
GB0011089D0 (en) 2000-05-08 2000-06-28 Black James Foundation Gastrin and cholecystokinin receptor ligands (11)
TW200614995A (en) 2004-11-10 2006-05-16 Nicholas Piramal India Ltd Tricyclic guanidine derivatives as sodium-proton exchange inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4357341A (en) * 1981-05-22 1982-11-02 The United States Of America As Represented By The Department Of Health And Human Services Specific irreversible antagonism of histamine receptors by photoaffinity actuated compounds
FR2674855B1 (en) * 1991-04-03 1994-01-14 Synthelabo PIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION.

Also Published As

Publication number Publication date
EP0994857A1 (en) 2000-04-26
AU8220598A (en) 1999-01-25
ZA985727B (en) 1999-01-27
JP2002507983A (en) 2002-03-12
WO1999001435A1 (en) 1999-01-14
FR2765580A1 (en) 1999-01-08
FR2765580B1 (en) 1999-08-06

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