AR013115A1 - COMPUESTOS DE 2,6-DI-t-BUTIL-4-[(DIMETIL-METOXIFENILSILIL)METIL-OXI]FENOL UTILES EN LA INHIBICION DE LA ARTERIOESCLEROSIS, COMPOSICIONES FARMACEUTICASY USOS EN LA FABRICACION DE MEDICAMENTOS QUE INCLUYEN DICHOS COMPUESTOS - Google Patents
COMPUESTOS DE 2,6-DI-t-BUTIL-4-[(DIMETIL-METOXIFENILSILIL)METIL-OXI]FENOL UTILES EN LA INHIBICION DE LA ARTERIOESCLEROSIS, COMPOSICIONES FARMACEUTICASY USOS EN LA FABRICACION DE MEDICAMENTOS QUE INCLUYEN DICHOS COMPUESTOSInfo
- Publication number
- AR013115A1 AR013115A1 ARP980102978A ARP980102978A AR013115A1 AR 013115 A1 AR013115 A1 AR 013115A1 AR P980102978 A ARP980102978 A AR P980102978A AR P980102978 A ARP980102978 A AR P980102978A AR 013115 A1 AR013115 A1 AR 013115A1
- Authority
- AR
- Argentina
- Prior art keywords
- butyl
- inhibition
- methyl
- compounds
- manufacture
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 230000005764 inhibitory process Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 title 1
- PVQMRIYBVJAQBE-UHFFFAOYSA-N 2,6-ditert-butyl-4-[[(2-methoxyphenyl)-dimethylsilyl]methoxy]phenol Chemical compound COC1=CC=CC=C1[Si](C)(C)COC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 PVQMRIYBVJAQBE-UHFFFAOYSA-N 0.000 abstract 1
- PJKUTMONJXDZNR-UHFFFAOYSA-N 2,6-ditert-butyl-4-[[(4-methoxyphenyl)-dimethylsilyl]methoxy]phenol Chemical compound C1=CC(OC)=CC=C1[Si](C)(C)COC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 PJKUTMONJXDZNR-UHFFFAOYSA-N 0.000 abstract 1
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 230000002930 anti-sclerotic effect Effects 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Vascular Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88184397A | 1997-06-25 | 1997-06-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR013115A1 true AR013115A1 (es) | 2000-12-13 |
Family
ID=25379324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980102978A AR013115A1 (es) | 1997-06-25 | 1998-06-22 | COMPUESTOS DE 2,6-DI-t-BUTIL-4-[(DIMETIL-METOXIFENILSILIL)METIL-OXI]FENOL UTILES EN LA INHIBICION DE LA ARTERIOESCLEROSIS, COMPOSICIONES FARMACEUTICASY USOS EN LA FABRICACION DE MEDICAMENTOS QUE INCLUYEN DICHOS COMPUESTOS |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0996623A1 (xx) |
| JP (1) | JP2002506443A (xx) |
| AR (1) | AR013115A1 (xx) |
| AU (1) | AU7588498A (xx) |
| CA (1) | CA2295232A1 (xx) |
| WO (1) | WO1998058937A1 (xx) |
| ZA (1) | ZA985324B (xx) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5155250A (en) * | 1990-07-05 | 1992-10-13 | Merrell Dow Pharmaceuticals Inc. | 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents |
| EP1468692B1 (en) * | 1993-12-10 | 2006-04-26 | Merrell Pharmaceuticals Inc. | Use of 2,6-di-alkyl-4-silyl-phenols for treating xanthoma |
| US5677291A (en) * | 1993-12-10 | 1997-10-14 | Hoechst Marion Roussel, Inc. | Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols |
| AU2209097A (en) * | 1996-04-30 | 1997-11-19 | Hoechst Marion Roussel, Inc. | Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2,6-di-alkyl-4-silyl-phenols |
| US5608095A (en) * | 1996-04-30 | 1997-03-04 | Hoechst Marion Roussel, Inc. | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents |
-
1998
- 1998-05-21 JP JP50442699A patent/JP2002506443A/ja active Pending
- 1998-05-21 AU AU75884/98A patent/AU7588498A/en not_active Abandoned
- 1998-05-21 EP EP98923645A patent/EP0996623A1/en not_active Withdrawn
- 1998-05-21 CA CA002295232A patent/CA2295232A1/en not_active Abandoned
- 1998-05-21 WO PCT/US1998/010443 patent/WO1998058937A1/en not_active Application Discontinuation
- 1998-06-18 ZA ZA985324A patent/ZA985324B/xx unknown
- 1998-06-22 AR ARP980102978A patent/AR013115A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2295232A1 (en) | 1998-12-30 |
| JP2002506443A (ja) | 2002-02-26 |
| EP0996623A1 (en) | 2000-05-03 |
| WO1998058937A1 (en) | 1998-12-30 |
| ZA985324B (en) | 1999-01-07 |
| AU7588498A (en) | 1999-01-04 |
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