AR012156A1 - NEUROMUSCULAR BLOCKERS DERIVED FROM ISOQUINOLINIO OF ULTRA SHORT ACTION, COMPOSITION CONTAINING THEM, USE OF SUCH COMPOUND, INTERMEDIARIES AND PROCESS FOR ITS PREPARATION. - Google Patents
NEUROMUSCULAR BLOCKERS DERIVED FROM ISOQUINOLINIO OF ULTRA SHORT ACTION, COMPOSITION CONTAINING THEM, USE OF SUCH COMPOUND, INTERMEDIARIES AND PROCESS FOR ITS PREPARATION.Info
- Publication number
- AR012156A1 AR012156A1 ARP980101340A ARP980101340A AR012156A1 AR 012156 A1 AR012156 A1 AR 012156A1 AR P980101340 A ARP980101340 A AR P980101340A AR P980101340 A ARP980101340 A AR P980101340A AR 012156 A1 AR012156 A1 AR 012156A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- ultra short
- isoquinolinio
- intermediaries
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Surgery (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Se describen agentes bloqueadores neuromusculares de accion ultra corta de la formula (I) que son utiles como relajantes del musculo esquelético duranteel proceso de intubacion de emergencia, cirugía de rutina y los medios postoperatorios,en donde X es halogeno, h es 1 a 2; Y es hidrogeno o metoxi;Z1 y Z2 son metilo; W1 y W2 son átomos de carbono; y A es un anion farmacéuticamente aceptable. También se descubren composiciones farmacéuticasque los contienen, método parain ducir la parálisis utilizando dichos compuestos, uso de dichos compuestos intermediarios y proceso para lapreparacion.Ultra short acting neuromuscular blocking agents of formula (I) are described that are useful as relaxants of the skeletal muscle during the process of emergency intubation, routine surgery and the postoperative means, where X is halogen, h is 1 to 2; Y is hydrogen or methoxy, Z1 and Z2 are methyl; W1 and W2 are carbon atoms; and A is a pharmaceutically acceptable anion. Pharmaceutical compositions containing them are also discovered, a method to induce paralysis using said compounds, use of said intermediates and a process for the preparation.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9706117.0A GB9706117D0 (en) | 1997-03-25 | 1997-03-25 | Ultra-short acting neuromuscular blockers |
| GBGB9724987.4A GB9724987D0 (en) | 1997-11-27 | 1997-11-27 | Ultra-short acting neuromuscular blockers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR012156A1 true AR012156A1 (en) | 2000-09-27 |
Family
ID=26311255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980101340A AR012156A1 (en) | 1997-03-25 | 1998-03-24 | NEUROMUSCULAR BLOCKERS DERIVED FROM ISOQUINOLINIO OF ULTRA SHORT ACTION, COMPOSITION CONTAINING THEM, USE OF SUCH COMPOUND, INTERMEDIARIES AND PROCESS FOR ITS PREPARATION. |
Country Status (37)
| Country | Link |
|---|---|
| US (2) | US6187789B1 (en) |
| EP (4) | EP1526130A1 (en) |
| JP (3) | JP4112016B2 (en) |
| KR (2) | KR100554601B1 (en) |
| CN (1) | CN1203061C (en) |
| AP (1) | AP1797A (en) |
| AR (1) | AR012156A1 (en) |
| AT (3) | ATE295351T1 (en) |
| AU (2) | AU745382B2 (en) |
| BR (1) | BR9808422B1 (en) |
| CA (1) | CA2284802C (en) |
| CO (1) | CO4940499A1 (en) |
| CZ (1) | CZ293786B6 (en) |
| DE (3) | DE69840816D1 (en) |
| DK (2) | DK0975599T3 (en) |
| EA (1) | EA002224B1 (en) |
| EE (1) | EE04113B1 (en) |
| ES (2) | ES2210757T3 (en) |
| HK (1) | HK1023342A1 (en) |
| HR (1) | HRP980157B1 (en) |
| HU (1) | HU228230B1 (en) |
| ID (1) | ID22901A (en) |
| IL (1) | IL131918A (en) |
| IS (2) | IS2346B (en) |
| MA (1) | MA26476A1 (en) |
| MY (1) | MY121316A (en) |
| NO (1) | NO314726B1 (en) |
| NZ (1) | NZ337797A (en) |
| PE (1) | PE68399A1 (en) |
| PL (1) | PL190860B1 (en) |
| PT (2) | PT975599E (en) |
| RS (1) | RS49869B (en) |
| SI (1) | SI0975599T1 (en) |
| TR (1) | TR199902330T2 (en) |
| TW (1) | TW505635B (en) |
| UY (1) | UY24933A1 (en) |
| WO (2) | WO1998042674A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111662230A (en) * | 2019-03-06 | 2020-09-15 | 四川道珍科技有限公司 | Benzyl isoquinoline compound, preparation method and application |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2284802C (en) * | 1997-03-25 | 2009-06-16 | Cornell Research Foundation, Inc. | Substituted isoquinolines as ultra short acting neuromuscular blockers |
| US6911455B2 (en) * | 1999-12-22 | 2005-06-28 | Smithkline Beecham Corporation | Methods for preparing pharmaceutical formulations |
| US6844904B2 (en) * | 2002-12-07 | 2005-01-18 | Cubic Corporation | Fast PDLC device |
| WO2005041960A2 (en) * | 2003-10-28 | 2005-05-12 | Cornell Research Foundation, Inc. | Neuromuscular blocking agents and antagonists thereof |
| US8148398B2 (en) * | 2006-12-06 | 2012-04-03 | Cornell Research Foundation, Inc. | Intermediate duration neuromuscular blocking agents and antagonists thereof |
| AU2008222298A1 (en) * | 2007-03-08 | 2008-09-12 | Chemagis Ltd. | (1R,1'R)-atracurium salts separation process |
| AU2008231470A1 (en) * | 2007-03-26 | 2008-10-02 | Chemagis Ltd. | (1R,1'R)-atracurium salts separation process |
| WO2008132746A1 (en) * | 2007-05-01 | 2008-11-06 | Chemagis Ltd. | Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates |
| WO2008132748A1 (en) * | 2007-05-01 | 2008-11-06 | Chemagis Ltd. | Process for producing cisatracurium compounds and associated intermediates |
| CA2687157A1 (en) * | 2007-06-18 | 2008-12-24 | Chemagis Ltd. | (1r,1'r)-atracurium salts separation process |
| US20100256381A1 (en) * | 2007-07-09 | 2010-10-07 | Chemagis Ltd. | Process for producing cisatracurium and associated intermediates |
| BRPI0816519A2 (en) | 2007-10-29 | 2015-03-24 | Chemagis Ltd | Process for preparing an isomerically enriched r, r'-atracurium salt and r, r'-atracurium salt |
| CA2722651A1 (en) * | 2008-05-01 | 2009-11-05 | Chemagis Ltd. | Cisatracurium derivatives, preparation and uses thereof |
| WO2010107488A1 (en) * | 2009-03-17 | 2010-09-23 | Cornell University | Reversible nondepolarizing neuromuscular blockade agents and methods for their use |
| US9220700B2 (en) | 2009-08-19 | 2015-12-29 | Cornell University | Cysteine for physiological injection |
| WO2014005122A2 (en) * | 2012-06-29 | 2014-01-03 | Savarese John J | Asymmetrical reversible neuromuscular blocking agents of ultra-short, short, or intermediate duration |
| CN103373959A (en) * | 2013-06-14 | 2013-10-30 | 安徽省先锋制药有限公司 | Preparation method of cis-benzyl isoquinoline compound and application thereof |
| WO2014210369A2 (en) * | 2013-06-28 | 2014-12-31 | Cornell University | Reversal of cysteine-inactivated neuromuscular blocking drugs with combinations of reversal agents |
| CN108375644B (en) * | 2016-12-07 | 2021-11-30 | 四川科瑞德制药股份有限公司 | Analysis method of neuromuscular blocker intermediate |
| CN108938573B (en) * | 2017-05-26 | 2021-08-10 | 四川科瑞德制药股份有限公司 | Neuromuscular blocker composition and preparation method and application thereof |
| CN110776481B (en) * | 2018-07-24 | 2023-06-16 | 四川大学华西医院 | Biscationic compound, preparation method and application thereof |
| CN109776486A (en) * | 2019-02-26 | 2019-05-21 | 武汉松石科技股份有限公司 | A kind of preparation method of sulfuric acid Asia propyl ester |
| CN110117297A (en) * | 2019-04-10 | 2019-08-13 | 珠海市赛纬电子材料股份有限公司 | A kind of preparation method of 2- phosphate base sulfuric acid acrylic ester |
| TW202128628A (en) * | 2019-12-11 | 2021-08-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | A neuromuscular blocker and preparation method thereof |
| CN111471013B (en) * | 2020-05-26 | 2021-04-30 | 朗天药业(湖北)有限公司 | Mickura ammonium chloride and preparation method of injection thereof |
| CN111909089B (en) * | 2020-08-14 | 2023-04-14 | 广东嘉博制药有限公司 | Preparation method of mikui ammonium chloride reference substance |
| CN114057642B (en) * | 2021-12-10 | 2023-03-28 | 广东嘉博制药有限公司 | Synthetic method of mickey ammonium chloride intermediate |
| CN115073373A (en) * | 2022-07-08 | 2022-09-20 | 广东嘉博制药有限公司 | Method for asymmetric synthesis of (R) -5' -methoxy labdanin |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3004031A (en) * | 1958-07-03 | 1961-10-10 | Allen & Hauburys Ltd | Diquaternary salts of papaverino esters |
| AU506657B2 (en) * | 1975-12-10 | 1980-01-17 | Wellcome Foundation Limited, The | Isoquinoline derivatives |
| ZA784331B (en) * | 1977-08-01 | 1979-12-27 | Massachusetts Gen Hospital | Neuromuscular blocking agents |
| US4701460A (en) * | 1980-12-17 | 1987-10-20 | Burroughs Wellcome Co. | Long duration neuromuscular blocking agents |
| JPS5899465A (en) * | 1981-11-23 | 1983-06-13 | ザ・ウエルカム・フアウンデ−シヨン・リミテツド | Isoquinoline derivative |
| GB8418303D0 (en) * | 1984-07-18 | 1984-08-22 | Wellcome Found | Compounds |
| BG41897A1 (en) | 1985-07-19 | 1987-09-15 | Ivanov | Dichlormethylate of n, n'- 4, 10- dioxa- 3, 11- bis- tetrahydropapaverine and method for its preparation |
| GB9015473D0 (en) * | 1990-07-13 | 1990-08-29 | Wellcome Found | Neuromuscular blocking agents |
| JPH04112016A (en) * | 1990-09-03 | 1992-04-14 | Fuji Electric Co Ltd | Plunger for transfer mold and transfer molding device |
| US5240939A (en) * | 1991-10-31 | 1993-08-31 | Anaquest, Inc. | Nitrogen bridge tetrahydroisoquinolines |
| CA2284802C (en) * | 1997-03-25 | 2009-06-16 | Cornell Research Foundation, Inc. | Substituted isoquinolines as ultra short acting neuromuscular blockers |
-
1998
- 1998-03-23 CA CA002284802A patent/CA2284802C/en not_active Expired - Fee Related
- 1998-03-23 AT AT98912494T patent/ATE295351T1/en not_active IP Right Cessation
- 1998-03-23 ID IDW991103A patent/ID22901A/en unknown
- 1998-03-23 ES ES98922626T patent/ES2210757T3/en not_active Expired - Lifetime
- 1998-03-23 US US09/381,719 patent/US6187789B1/en not_active Expired - Lifetime
- 1998-03-23 WO PCT/EP1998/001651 patent/WO1998042674A1/en not_active Application Discontinuation
- 1998-03-23 CZ CZ19993404A patent/CZ293786B6/en not_active IP Right Cessation
- 1998-03-23 JP JP54323398A patent/JP4112016B2/en not_active Expired - Fee Related
- 1998-03-23 DE DE69840816T patent/DE69840816D1/en not_active Expired - Lifetime
- 1998-03-23 SI SI9830593T patent/SI0975599T1/en unknown
- 1998-03-23 AT AT98922626T patent/ATE254107T1/en active
- 1998-03-23 KR KR1019997008687A patent/KR100554601B1/en not_active IP Right Cessation
- 1998-03-23 EP EP05001475A patent/EP1526130A1/en not_active Withdrawn
- 1998-03-23 TR TR1999/02330T patent/TR199902330T2/en unknown
- 1998-03-23 NZ NZ337797A patent/NZ337797A/en not_active IP Right Cessation
- 1998-03-23 ES ES98912494T patent/ES2242275T3/en not_active Expired - Lifetime
- 1998-03-23 DE DE69830157T patent/DE69830157T2/en not_active Expired - Lifetime
- 1998-03-23 HU HU0001556A patent/HU228230B1/en not_active IP Right Cessation
- 1998-03-23 KR KR1020057019867A patent/KR100578443B1/en not_active IP Right Cessation
- 1998-03-23 IL IL13191898A patent/IL131918A/en not_active IP Right Cessation
- 1998-03-23 EE EEP199900424A patent/EE04113B1/en not_active IP Right Cessation
- 1998-03-23 AT AT03020565T patent/ATE430734T1/en not_active IP Right Cessation
- 1998-03-23 AU AU75210/98A patent/AU745382B2/en not_active Ceased
- 1998-03-23 BR BRPI9808422-4A patent/BR9808422B1/en not_active IP Right Cessation
- 1998-03-23 DK DK98922626T patent/DK0975599T3/en active
- 1998-03-23 PL PL335885A patent/PL190860B1/en not_active IP Right Cessation
- 1998-03-23 EP EP98912494A patent/EP0971898B1/en not_active Expired - Lifetime
- 1998-03-23 WO PCT/EP1998/001652 patent/WO1998042675A1/en active IP Right Grant
- 1998-03-23 MY MYPI98001252A patent/MY121316A/en unknown
- 1998-03-23 EP EP98922626A patent/EP0975599B1/en not_active Expired - Lifetime
- 1998-03-23 EA EA199900756A patent/EA002224B1/en not_active IP Right Cessation
- 1998-03-23 PE PE1998000209A patent/PE68399A1/en not_active Application Discontinuation
- 1998-03-23 US US09/381,721 patent/US6177445B1/en not_active Expired - Fee Related
- 1998-03-23 AU AU67305/98A patent/AU6730598A/en not_active Abandoned
- 1998-03-23 MA MA25006A patent/MA26476A1/en unknown
- 1998-03-23 JP JP54323298A patent/JP4112015B2/en not_active Expired - Fee Related
- 1998-03-23 DK DK98912494T patent/DK0971898T3/en active
- 1998-03-23 DE DE69819703T patent/DE69819703T2/en not_active Expired - Lifetime
- 1998-03-23 PT PT98922626T patent/PT975599E/en unknown
- 1998-03-23 PT PT98912494T patent/PT971898E/en unknown
- 1998-03-23 EP EP03020565A patent/EP1380573B1/en not_active Expired - Lifetime
- 1998-03-23 CN CNB988053004A patent/CN1203061C/en not_active Expired - Fee Related
- 1998-03-23 AP APAP/P/1999/001658A patent/AP1797A/en active
- 1998-03-23 RS YUP-483/99A patent/RS49869B/en unknown
- 1998-03-24 AR ARP980101340A patent/AR012156A1/en active IP Right Grant
- 1998-03-24 UY UY24933A patent/UY24933A1/en not_active IP Right Cessation
- 1998-03-24 HR HR980157A patent/HRP980157B1/en not_active IP Right Cessation
- 1998-03-25 CO CO98016617A patent/CO4940499A1/en unknown
- 1998-04-29 TW TW087106631A patent/TW505635B/en not_active IP Right Cessation
-
1999
- 1999-09-17 IS IS5185A patent/IS2346B/en unknown
- 1999-09-24 NO NO19994680A patent/NO314726B1/en not_active IP Right Cessation
-
2000
- 2000-04-25 HK HK00102447A patent/HK1023342A1/en not_active IP Right Cessation
-
2007
- 2007-09-25 JP JP2007247928A patent/JP2008019272A/en active Pending
-
2008
- 2008-03-03 IS IS8717A patent/IS8717A/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111662230A (en) * | 2019-03-06 | 2020-09-15 | 四川道珍科技有限公司 | Benzyl isoquinoline compound, preparation method and application |
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