AR009627A1 - DERIVATIVES OF N- (IMIDAZOLYLBUTYL) BENZENOSULFONAMIDE ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS - Google Patents

DERIVATIVES OF N- (IMIDAZOLYLBUTYL) BENZENOSULFONAMIDE ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS

Info

Publication number
AR009627A1
AR009627A1 ARP970105455A ARP970105455A AR009627A1 AR 009627 A1 AR009627 A1 AR 009627A1 AR P970105455 A ARP970105455 A AR P970105455A AR P970105455 A ARP970105455 A AR P970105455A AR 009627 A1 AR009627 A1 AR 009627A1
Authority
AR
Argentina
Prior art keywords
alkyl
application
benzenosulfonamide
imidazolylbutyl
therapeutics
Prior art date
Application number
ARP970105455A
Other languages
Spanish (es)
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of AR009627A1 publication Critical patent/AR009627A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos de formula (I): en donde, entre otros significados R1 y R1 representan hidrogeno, halogeno o (C1-C4)alquilo; R2 representa un grupopiperidin-1-ilo, 1,2,3,6-tetrahidropidin-1-ilo eventualmente substituidos, hexahidro-1H-azepin-1-ilo, heptahidroazocin-1-ilo, octahidro-1H-azonin-1-ilo,(1) donde: (A-B = ONR, m = 1 a 2 y p = 1 a 2); (2) donde: (Q = carbono o nitrogeno, D = (C1-C4)alquilo o -CH2CH3, y r = 1 a 3), R3 representa (C1-C5)alquilo, -COR5 [siendo R5 (C1-C4)alquilo,-(CH-2)nOCH3, -CH2O(C2H4O)nCH3, -(CH2)nCF3, -(CH-2)nOH (n igual 1 a 4)], -SO2R6, -CONHR6, -SO2N(R6)2 (siendo R6(C1-C4)alquilo; R4 representa hidrogeno o halogeno y A representa fenilo o heterociclo eventualmente substituidos o ciclo(C5-C8)alquilo. Aplicacion enterapéutica: propiedades antitromboticas.Compounds of formula (I): wherein, among other meanings R1 and R1 represent hydrogen, halogen or (C1-C4) alkyl; R2 represents a group piperidin-1-yl, optionally substituted 1,2,3,6-tetrahydropidin-1-yl, hexahydro-1H-azepin-1-yl, heptahydroazocin-1-yl, octahydro-1H-azonin-1-yl , (1) where: (AB = ONR, m = 1 to 2 and p = 1 to 2); (2) where: (Q = carbon or nitrogen, D = (C1-C4) alkyl or -CH2CH3, and r = 1 to 3), R3 represents (C1-C5) alkyl, -COR5 [where R5 (C1-C4) alkyl, - (CH-2) nOCH3, -CH2O (C2H4O) nCH3, - (CH2) nCF3, - (CH-2) nOH (n equal 1 to 4)], -SO2R6, -CONHR6, -SO2N (R6) 2 (where R6 (C1-C4) is alkyl; R4 represents hydrogen or halogen and A represents optionally substituted phenyl or heterocycle or (C5-C8) alkyl. Enteratherapeutic application: antithrombotic properties.

ARP970105455A 1996-11-22 1997-11-21 DERIVATIVES OF N- (IMIDAZOLYLBUTYL) BENZENOSULFONAMIDE ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS AR009627A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9614309A FR2756285B1 (en) 1996-11-22 1996-11-22 N- (IMIDAZOLYLBUTYL) BENZENESULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (1)

Publication Number Publication Date
AR009627A1 true AR009627A1 (en) 2000-04-26

Family

ID=9497920

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970105455A AR009627A1 (en) 1996-11-22 1997-11-21 DERIVATIVES OF N- (IMIDAZOLYLBUTYL) BENZENOSULFONAMIDE ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS

Country Status (20)

Country Link
EP (1) EP0946517A1 (en)
JP (1) JP2001504128A (en)
KR (1) KR20000069063A (en)
CN (1) CN1238765A (en)
AR (1) AR009627A1 (en)
AU (1) AU5226498A (en)
BG (1) BG103414A (en)
BR (1) BR9713291A (en)
CA (1) CA2270478A1 (en)
CO (1) CO4910158A1 (en)
CZ (1) CZ178299A3 (en)
EE (1) EE9900201A (en)
FR (1) FR2756285B1 (en)
HU (1) HUP9904599A2 (en)
IL (1) IL129546A0 (en)
NO (1) NO992436L (en)
SK (1) SK66799A3 (en)
TR (1) TR199901143T2 (en)
WO (1) WO1998022443A1 (en)
ZA (1) ZA9710515B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2783521B1 (en) * 1998-09-18 2002-04-26 Synthelabo N- (ARGINYL) BENZENESULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2806722B1 (en) * 2000-03-23 2002-05-17 Sanofi Synthelabo N- (HETEROCYCLYLBUTYL) BENZENE- OR PYRIDINE SULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
JP6698643B2 (en) 2014-09-29 2020-05-27 セリックス バイオ プライヴェート リミテッドＣｅｌｌｉｘ Ｂｉｏ Ｐｒｉｖａｔｅ Ｌｉｍｉｔｅｄ Compositions and methods for the treatment of multiple sclerosis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2689130B1 (en) * 1992-03-30 1994-05-27 Synthelabo DERIVATIVES OF 1- [2 (ARYLSULFONYLAMINO) ETHYL-1-OXO] PIPERIDINE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION.
FR2710066B1 (en) * 1993-09-14 1995-10-20 Synthelabo 1- [2-amino-5- [1- (triphenylmethyl-1H-imidazol-4-yl] -1-oxopentyl] piperidine derivatives, their preparation and their use as synthesis intermediates.
FR2727410B1 (en) * 1994-11-25 1996-12-20 Synthelabo SULFONYL CHLORIDES, THEIR PREPARATION AND THEIR USE AS SYNTHESIS INTERMEDIATES
FR2728570B1 (en) * 1994-12-23 1997-04-11 Synthelabo 1-OXO-2- (PHENYLSULFONYLAMINO) PENTYLPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
DE19548797A1 (en) * 1995-12-27 1997-07-03 Thomae Gmbh Dr K New amino-imidazole substituted amino acid derivatives

Also Published As

Publication number Publication date
CN1238765A (en) 1999-12-15
AU5226498A (en) 1998-06-10
WO1998022443A1 (en) 1998-05-28
EP0946517A1 (en) 1999-10-06
IL129546A0 (en) 2000-02-29
CZ178299A3 (en) 1999-08-11
BR9713291A (en) 1999-10-26
TR199901143T2 (en) 1999-08-23
NO992436D0 (en) 1999-05-20
BG103414A (en) 2000-01-31
EE9900201A (en) 1999-12-15
KR20000069063A (en) 2000-11-25
NO992436L (en) 1999-07-22
JP2001504128A (en) 2001-03-27
ZA9710515B (en) 1998-06-10
CO4910158A1 (en) 2000-04-24
CA2270478A1 (en) 1998-05-28
HUP9904599A2 (en) 2000-06-28
FR2756285B1 (en) 1998-12-18
SK66799A3 (en) 2000-02-14
FR2756285A1 (en) 1998-05-29

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