Se relaciona con nuevos derivados de piperazina y proceso de preparacion, que comprende, un nuevo compuesto que tiene intensas actividades antitumor dela formula general (I), en la que R1 y R2 son independientemente hidrogeno, C1-C8 alquilosub stituido o no substituido, C3-C6 cicloalquilo substituido ono substituido, C2-C8 alquilo no saturado substituido o no substituido, ketona, arilo substituido o no substituido, C1-C4 alcoxi substituido o no substituido,arilohidroxi substituido ono sub stituido, amina substituido o no substituido, C1-C4 éster inferior, C1-C4 tioéster inferior, tiol, carboxilo substituido o nosubstituido, epoxi,C1-C4 tioalcoxi inferior substituido o no substituido; o se fusionan R1 y R2 para formar cadenasC3-C4 s aturado o no saturado; R3, R4, R5,R6, y R7 son independientemente hidrogeno, halogeno, hidroxi, nitro, C1-C4 éster inferior, C1-C4 alquilo inferior, C1-C4 tioalquilo inferior, C3-C6cicloalquilo substituido o no substituido, C1-C4 alcoxiinferior , C1-C4 tioalcoxi inferior, arilo substituido o no substituido, arilalcoxi inferiorsubstituido o no substituido, alquiloamino inferior substituido o no substituido, o alquilo inferior substituido o carbamato nosubstituido; oentre R3, R4, R5, R6 y R7, dos grupos adyacentes están ligados entre sí para formar 1,2-fenileno o 2,3-naftileno; X es oxígeno, azufre, o imino substituidoo no substituido; Y está ligado en la posicion 3- o posicion 4- de la parte del anillo aromáti ca en donde Y es oxígeno o -NR8_- (en qué, R8 son el mismocon el antedicho R3-); Z es hidroxi, C1-C4 alcoxi inferior, C1-C4 tioalcoxi inferior, ariloxi substituido o no substituido, C1-C4 alquiloamino inferior,substituido ocicloamina no substitu ida que contiene 1-5 átomos de nitrogeno; A es nitrogeno o -CH=; sus sales de agregado ácido farmacéuticamente aceptable yIt is related to new piperazine derivatives and the preparation process, which comprises a new compound that has intense antitumor activities of the general formula (I), in which R1 and R2 are independently hydrogen, C1-C8 alkyl substituted or unsubstituted, C3 -C6 substituted or unsubstituted cycloalkyl, C2-C8 substituted or unsubstituted unsaturated alkyl, ketone, substituted or unsubstituted aryl, C1-C4 substituted or unsubstituted alkoxy, substituted or unsubstituted or unsubstituted arylohydroxy, substituted or unsubstituted amine, C1-C4 lower ester, C1-C4 lower thioester, thiol, substituted or unsubstituted carboxyl, epoxy, C1-C4 substituted or unsubstituted lower thioalkoxy; or R1 and R2 fuse to form C3-C4 chains s unsaturated or unsaturated; R3, R4, R5, R6, and R7 are independently hydrogen, halogen, hydroxy, nitro, C1-C4 lower ester, C1-C4 lower alkyl, C1-C4 lower thioalkyl, substituted or unsubstituted C3-C6cycloalkyl, C1-C4 lower alkoxy , C1-C4 thio lower alkoxy, substituted or unsubstituted aryl, substituted or unsubstituted arylalkoxy lower, substituted or unsubstituted lower alkyl amine, or substituted lower alkyl or unsubstituted carbamate; Between R3, R4, R5, R6 and R7, two adjacent groups are linked together to form 1,2-phenylene or 2,3-naphthylene; X is oxygen, sulfur, or substituted or unsubstituted imino; Y is linked at position 3- or position 4- of the part of the aromatic ring where Y is oxygen or -NR8_- (in which, R8 are the same with the aforementioned R3-); Z is hydroxy, C1-C4 lower alkoxy, C1-C4 lower thioalkoxy, substituted or unsubstituted aryloxy, C1-C4 lower alkyl, substituted or unsubstituted ocycloamine containing 1-5 nitrogen atoms; A is nitrogen or -CH =; its pharmaceutically acceptable acid aggregate salts and