AR004223A1 - COMPOSITIONS TO INHIBIT THE ADDING OF PLATELETS AND THE USE OF THE SAME IN THE MANUFACTURE OF A MEDICINAL PRODUCT. - Google Patents

COMPOSITIONS TO INHIBIT THE ADDING OF PLATELETS AND THE USE OF THE SAME IN THE MANUFACTURE OF A MEDICINAL PRODUCT.

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Publication number
AR004223A1
AR004223A1 ARP960104786A ARP960104786A AR004223A1 AR 004223 A1 AR004223 A1 AR 004223A1 AR P960104786 A ARP960104786 A AR P960104786A AR P960104786 A ARP960104786 A AR P960104786A AR 004223 A1 AR004223 A1 AR 004223A1
Authority
AR
Argentina
Prior art keywords
manufacture
effective
platelets
inhibit
compositions
Prior art date
Application number
ARP960104786A
Other languages
Spanish (es)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of AR004223A1 publication Critical patent/AR004223A1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención es una composición farmacéutica para inhibir la agregación de plaquetas, para administrarla intra-venosamente a un paciente, que comprende:a) una cantidad farmacéuticamente efectiva de una compuesto que tiene la fórmula (I), donde: R4 es arilo, alquilo C1-10 ó arilalquilo C1-10; R5 es (II),donde R8 es hidroxi o alquiloxi C1-10; p es cero ó uno; y m es un número entero desde dos hasta seis; por ej. ácido 2-S-(n-butilsulfonilamino)-3-[4-(4-(piperidin-4-il)butiloxi)fenil]propiónico: b) una cantidad farmacéuticamente aceptable de un tampón citrato, efectivo para proveer un pH desde alrededor de5 hasta alrededor de 7; y c) una cantidad farmacéuticamente aceptable de un agente ajustador de tonicidad, efectivo para hacer a la formulaciónsustancialmente isotónica con la presión osmótica del sistema biológico del paciente. Se describe además el uso de la misma en la manufactura de unmedicamento.The invention is a pharmaceutical composition for inhibiting platelet aggregation, for intravenous administration to a patient, comprising: a) a pharmaceutically effective amount of a compound having formula (I), where: R4 is aryl, C1-alkyl -10 or C1-10 arylalkyl; R5 is (II), where R8 is hydroxy or C1-10 alkyloxy; p is zero or one; and m is an integer from two to six; for example 2-S- (n-Butylsulfonylamino) -3- [4- (4- (piperidin-4-yl) butyloxy) phenyl] propionic acid: b) a pharmaceutically acceptable amount of a citrate buffer, effective in providing a pH from about from 5 to around 7; and c) a pharmaceutically acceptable amount of a tonicity adjusting agent, effective to render the formulation substantially isotonic with the osmotic pressure of the patient's biological system. The use of it in the manufacture of a drug is also described.

ARP960104786A 1995-10-27 1996-10-17 COMPOSITIONS TO INHIBIT THE ADDING OF PLATELETS AND THE USE OF THE SAME IN THE MANUFACTURE OF A MEDICINAL PRODUCT. AR004223A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US590795P 1995-10-27 1995-10-27
GBGB9603721.3A GB9603721D0 (en) 1996-02-22 1996-02-22 Composition for inhibiting platelet aggregation

Publications (1)

Publication Number Publication Date
AR004223A1 true AR004223A1 (en) 1998-11-04

Family

ID=10789191

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960104786A AR004223A1 (en) 1995-10-27 1996-10-17 COMPOSITIONS TO INHIBIT THE ADDING OF PLATELETS AND THE USE OF THE SAME IN THE MANUFACTURE OF A MEDICINAL PRODUCT.

Country Status (2)

Country Link
AR (1) AR004223A1 (en)
GB (1) GB9603721D0 (en)

Also Published As

Publication number Publication date
GB9603721D0 (en) 1996-04-24

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