AR003925A1 -
MUSCARINIC ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, USE OF SUCH MUSCARINIC ANTAGONISTS TO PREPARE MEDICINES FOR THE TREATMENT OF COGNITIVE DISORDERS, KIT FOR THE TREATMENT CONTAINING THEM
- Google Patents
MUSCARINIC ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, USE OF SUCH MUSCARINIC ANTAGONISTS TO PREPARE MEDICINES FOR THE TREATMENT OF COGNITIVE DISORDERS, KIT FOR THE TREATMENT CONTAINING THEM
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Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Los compuestos de piperazina di-N-substituida o de piperazina 1,4- disubstituida, de acuerdo con la fórmula (I) (inclusive todos los isómeros,sales, ésteres y solvatos), donde R, R1, R2, R3, R4, R21, R27, R28, X, Y y Z tienen ladefinició n indicada en la memoria, son antagonistas muscarínicosútiles para el tratamiento de desórdenes cognoscitivos, tales como la enfermedad de Alzheimer, uso de los antagonistas muscarínicos para lapreparación de medicamentos.Asimismo se dan a conocer composiciones farmacéuticas y métodos de preparación. También se dan a conocer combinacionesde los compuestos de la fórmula anterior y otros compuestos capaces de incrementar la liberación deacetilcolina con inhibidores de la acetilcolinesterasa; y un kit para tratamiento que los contiene.Di-N-substituted piperazine or 1,4-disubstituted piperazine compounds according to formula (I) (including all isomers, salts, esters and solvates), where R, R1, R2, R3, R4, R21, R27, R28, X, Y and Z have the definition indicated in the specification, they are muscarinic antagonists useful for the treatment of cognitive disorders, such as Alzheimer's disease, the use of muscarinic antagonists for the preparation of drugs. To know pharmaceutical compositions and preparation methods. Combinations of the compounds of the above formula and other compounds capable of increasing acetylcholine release with acetylcholinesterase inhibitors are also disclosed; and a treatment kit that contains them.
ARP960101424A1995-02-231996-02-16
MUSCARINIC ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, USE OF SUCH MUSCARINIC ANTAGONISTS TO PREPARE MEDICINES FOR THE TREATMENT OF COGNITIVE DISORDERS, KIT FOR THE TREATMENT CONTAINING THEM
AR003925A1
(en)
MUSCARINIC ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, USE OF SUCH MUSCARINIC ANTAGONISTS TO PREPARE MEDICINES FOR THE TREATMENT OF COGNITIVE DISORDERS, KIT FOR THE TREATMENT CONTAINING THEM
IMIDAZOPIRIMIDINE DERIVATIVES AND TRIAZOLOPIRIMIDINE DERIVATIVES, A PROCEDURE FOR THEIR PREPARATION, MEDICINES, A PHARMACEUTICAL COMPOSITION, AND THE USE OF SUCH DERIVATIVES FOR THE PREPARATION OF MEDICINES
DERIVATIVES OF SULFONAMIDE, A PROCEDURE FOR ITS PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM, USE OF SUCH DERIVATIVES FOR THE PREPARATION OF A MEDICINAL PRODUCT.
COMPOUNDS DERIVED FROM 3H-QUINAZOLIN-4-ONA, ITS PREPARATION PROCESS, PHARMACEUTICAL COMPOSITION CONTAINING THEM, AND USE IN THE TREATMENT AND PREVENTION OF DISEASES MEDIATED BY MAO-B INHIBITORS, SUCH AS THE DISEASE OF ALZHEIMER AND DEMENCIER
COMPOUNDS DERIVED FROM OCTAHIDRO-PIRROLO [1,2-A] -PYRAZINE 2,7-SUBSTITUTES, PHARMACEUTICAL COMPOSITIONS AND USE OF SUCH COMPOUNDS FOR THE MANUFACTURE OF A MEDICINAL PRODUCT.
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COMPOUNDS OF 4-AMINO-AZEPAN-3-ONA, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM, USEFUL INTERMEDIARIES IN THE SYNTHESIS OF SUCH COMPOUNDS, PROCEDURE FOR THE SYNTHESIS OF SUCH COMPOUNDS, AND USE OF SUCH COMPOUNDS IN THE MANUFACTURE OF MEDICINES