AR003767A1 - A POLYMERIZABLE MACROMER OF FREE RADICALS, PROCEDURE FOR ITS PREPARATION, POLYMER THAT INCLUDES SUCH MACROMER, MOLDED PIECE, BIOMEDICAL ARTICLE, CORNEAL IMPLANT, MEDICAL GROWTH SUBSTRATE, CONTAINING SUCH A MACRO POLYMER AND - Google Patents

A POLYMERIZABLE MACROMER OF FREE RADICALS, PROCEDURE FOR ITS PREPARATION, POLYMER THAT INCLUDES SUCH MACROMER, MOLDED PIECE, BIOMEDICAL ARTICLE, CORNEAL IMPLANT, MEDICAL GROWTH SUBSTRATE, CONTAINING SUCH A MACRO POLYMER AND

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Publication number
AR003767A1
AR003767A1 ARP960104570A ARP960104570A AR003767A1 AR 003767 A1 AR003767 A1 AR 003767A1 AR P960104570 A ARP960104570 A AR P960104570A AR P960104570 A ARP960104570 A AR P960104570A AR 003767 A1 AR003767 A1 AR 003767A1
Authority
AR
Argentina
Prior art keywords
macromer
polymer
independently
procedure
preparation
Prior art date
Application number
ARP960104570A
Other languages
Spanish (es)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Priority to ARP960104570A priority Critical patent/AR003767A1/en
Publication of AR003767A1 publication Critical patent/AR003767A1/en

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  • Macromonomer-Based Addition Polymer (AREA)

Abstract

La presente invención se refiere a un macrómero polimerizable de radicales libres de la fórmula (I) basado en un perfluoroalquiléter no substituido osimétricamente substituido; un polímero que comprende el producto de la polimerización deun macrómero nuevo, sólo o junto con por lo menos uncomonómero vínilico; un procedimiento para la preparación de un macrómero y un polímero; piezas moldeadas, lentes de contacto, implantes córneos y artículosbiomédicos fabricados a partir de unpolíme ro; y artículos recubiertos con un macrómero de la fórmula (I) o un producto de polimerización del mismo.P1-(Y)m -(L-X1)p - Q-(X1-L)p -(Y)m -P1 (I) en donde cada P1 independientemente de los otros, es ungrupo p olimerizable deradicales libres; cada Y, independientemente de los otros, es -CONHCOO-, CONHCONH-, -OCONHCO-, -NHCO-, -CONH-, NHCONH-, -COO-, -OCO-, -NHCOO- ú-OCONH-; m y p, independientemente uno del otro, son 0 ó 1; cada L, indep endientemente de los otros, es un radical divalente de un compuestoorgánico que tiene hasta 20 átomos de carbono; cada X1 independientemente de los otros, es -NHCO-, -CONH-, -NHCONH-, -COO-, OCO-, -NHCOO- ú OCONH- ; y Q esun fragmento depolímero bivalente compuesto por los segmentos: (a) -(E)k-Z-CF2- (OCF2)x -(OCF2CF2)y -OCF2-Z- (E)k-, en donde x + y es unnúmero en el rango de 10 a 30; cada Z, independientemente de los otros, es un radical divalente que tienehasta 12 átomo s de carbono o un enlace; cada E,independientemente de los otros, es -(OCH2CH2)q-, en donde q tiene un valor de desde 0 a 2 y en donde la ligadura -Z-E- representa la secuencia -Z-(OCH2CH2)q-y k es 0 ó 1; fórmula (b) en donde n es unentero de 5 a 1 00; Alk es alquileno que tiene hasta 20 átomos de carbono; 80-100% de los radicales R1, R2, R3 y R4The present invention relates to a free radical polymerizable macromer of formula (I) based on an osymmetrically substituted unsubstituted perfluoroalkyl ether; a polymer comprising the product of the polymerization of a new macromer, alone or together with at least one vinyl comonomer; a procedure for the preparation of a macromer and a polymer; castings, contact lenses, corneal implants, and biomedical articles made from a polymer; and articles coated with a macromer of formula (I) or a polymerization product thereof. P1- (Y) m - (L-X1) p - Q- (X1-L) p - (Y) m -P1 ( I) where each P1 independently of the others is a polymerizable group of free radicals; each Y, independently of the others, is -CONHCOO-, CONHCONH-, -OCONHCO-, -NHCO-, -CONH-, NHCONH-, -COO-, -OCO-, -NHCOO- ú-OCONH-; m and p, independently of each other, are 0 or 1; each L, independently of the others, is a divalent radical of an organic compound having up to 20 carbon atoms; each X1 independently of the others, is -NHCO-, -CONH-, -NHCONH-, -COO-, OCO-, -NHCOO- or OCONH-; and Q is a bivalent polymer fragment composed of the segments: (a) - (E) kZ-CF2- (OCF2) x - (OCF2CF2) and -OCF2-Z- (E) k-, where x + y is a number in the range of 10 to 30; each Z, independently of the others, is a divalent radical having up to 12 carbon atoms or a bond; each E, independently of the others, is - (OCH2CH2) q-, where q has a value from 0 to 2 and where the ligature -ZE- represents the sequence -Z- (OCH2CH2) q and k is 0 or 1 ; formula (b) where n is an integer from 5 to 1 00; Alk is alkylene having up to 20 carbon atoms; 80-100% of radicals R1, R2, R3 and R4

ARP960104570A 1996-10-02 1996-10-02 A POLYMERIZABLE MACROMER OF FREE RADICALS, PROCEDURE FOR ITS PREPARATION, POLYMER THAT INCLUDES SUCH MACROMER, MOLDED PIECE, BIOMEDICAL ARTICLE, CORNEAL IMPLANT, MEDICAL GROWTH SUBSTRATE, CONTAINING SUCH A MACRO POLYMER AND AR003767A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ARP960104570A AR003767A1 (en) 1996-10-02 1996-10-02 A POLYMERIZABLE MACROMER OF FREE RADICALS, PROCEDURE FOR ITS PREPARATION, POLYMER THAT INCLUDES SUCH MACROMER, MOLDED PIECE, BIOMEDICAL ARTICLE, CORNEAL IMPLANT, MEDICAL GROWTH SUBSTRATE, CONTAINING SUCH A MACRO POLYMER AND

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ARP960104570A AR003767A1 (en) 1996-10-02 1996-10-02 A POLYMERIZABLE MACROMER OF FREE RADICALS, PROCEDURE FOR ITS PREPARATION, POLYMER THAT INCLUDES SUCH MACROMER, MOLDED PIECE, BIOMEDICAL ARTICLE, CORNEAL IMPLANT, MEDICAL GROWTH SUBSTRATE, CONTAINING SUCH A MACRO POLYMER AND

Publications (1)

Publication Number Publication Date
AR003767A1 true AR003767A1 (en) 1998-09-09

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ARP960104570A AR003767A1 (en) 1996-10-02 1996-10-02 A POLYMERIZABLE MACROMER OF FREE RADICALS, PROCEDURE FOR ITS PREPARATION, POLYMER THAT INCLUDES SUCH MACROMER, MOLDED PIECE, BIOMEDICAL ARTICLE, CORNEAL IMPLANT, MEDICAL GROWTH SUBSTRATE, CONTAINING SUCH A MACRO POLYMER AND

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AR (1) AR003767A1 (en)

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