AR000283A1 - Un procedimiento para preparar ranitidina n-Ä2-ÄÄÄ5-(dimetilamino)metil-2-furalnilÜmetilÜetilÜ-n'-metil-2-nitro-1,1-etenodiamina y sus sales farmacéuticamente aceptables - Google Patents

Un procedimiento para preparar ranitidina n-Ä2-ÄÄÄ5-(dimetilamino)metil-2-furalnilÜmetilÜetilÜ-n'-metil-2-nitro-1,1-etenodiamina y sus sales farmacéuticamente aceptables

Info

Publication number
AR000283A1
AR000283A1 AR33449995A AR33449995A AR000283A1 AR 000283 A1 AR000283 A1 AR 000283A1 AR 33449995 A AR33449995 A AR 33449995A AR 33449995 A AR33449995 A AR 33449995A AR 000283 A1 AR000283 A1 AR 000283A1
Authority
AR
Argentina
Prior art keywords
methyl
dimethylamino
pharmaceutically acceptable
furan
acceptable salts
Prior art date
Application number
AR33449995A
Other languages
English (en)
Inventor
Robert Michael Strom
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of AR000283A1 publication Critical patent/AR000283A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

El nuevo procedimiento para preparar ranitidina y sus sales farmacéuticamente aceptables comprende hacer reaccionar2-nitrometilenotiazolidina con metilamina para dar una mezcla de reacción y hacer reaccionar después a la mezclade reacción con un derivado de5-[(dimetilamino)metil]furano o una sal del mismo seleccionado entre 5-[(dimetilamino)metil]-2-(clorometil)furano,5-[(dimetilamino)metil]-2-(bromometil)furano, 5-[(dimetilamino) metil]-2-(metalsulfoniloximetil)furano,5-[(dimetilamino)metil]-2-(bencensulfoniloximetil)furano, y eventualmente poner en contacto la ranitidina obtenida con un ácido farmacéuticamente aceptablepara obtener la correspondiente sal.
AR33449995A 1994-12-08 1995-12-05 Un procedimiento para preparar ranitidina n-Ä2-ÄÄÄ5-(dimetilamino)metil-2-furalnilÜmetilÜetilÜ-n'-metil-2-nitro-1,1-etenodiamina y sus sales farmacéuticamente aceptables AR000283A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US35198594A 1994-12-08 1994-12-08

Publications (1)

Publication Number Publication Date
AR000283A1 true AR000283A1 (es) 1997-06-18

Family

ID=23383289

Family Applications (1)

Application Number Title Priority Date Filing Date
AR33449995A AR000283A1 (es) 1994-12-08 1995-12-05 Un procedimiento para preparar ranitidina n-Ä2-ÄÄÄ5-(dimetilamino)metil-2-furalnilÜmetilÜetilÜ-n'-metil-2-nitro-1,1-etenodiamina y sus sales farmacéuticamente aceptables

Country Status (5)

Country Link
US (1) US5672724A (es)
KR (1) KR100395703B1 (es)
AR (1) AR000283A1 (es)
TW (1) TW305825B (es)
ZA (1) ZA9510276B (es)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1565966A (en) * 1976-08-04 1980-04-23 Allen & Hanburys Ltd Aminoalkyl furan derivatives
US4169855A (en) * 1976-08-04 1979-10-02 Allen & Hansbury, Limited N'-derivatives of n-(2-mercapto-ethyl)-2-nitro-1,1-ethenediamine
CA1171096A (en) * 1980-01-08 1984-07-17 Glaxo Group Limited Process for the preparation of a furan derivative
CA1181084A (en) * 1980-01-08 1985-01-15 Glaxo Group Limited Process for the preparation of a furan derivative
AR229878A1 (es) * 1981-05-07 1983-12-30 Glaxo Group Ltd Procedimiento para preparar ranitidina
KR950009825B1 (ko) * 1986-03-28 1995-08-29 자누스 화마스티씨 에스.알.엘. 치료학적 항궤양 활성이 있는 니페로티딘의 합성방법
IT1215344B (it) * 1987-01-27 1990-02-08 Dessy S R L Ora Recordati Farm Procedimento per la preparazione di composti ad attivita' anti-ulcera.

Also Published As

Publication number Publication date
ZA9510276B (en) 1996-05-30
TW305825B (es) 1997-05-21
US5672724A (en) 1997-09-30
KR100395703B1 (ko) 2003-11-28

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