WO2019137079A1

WO2019137079A1 - Auditory sensitivity detection system based on stimulus-frequency otoacoustic emissions

Info

Publication number: WO2019137079A1
Application number: PCT/CN2018/113601
Authority: WO
Inventors: 宫琴
Original assignee: 清华大学
Priority date: 2018-01-11
Filing date: 2018-11-02
Publication date: 2019-07-18
Also published as: CN108209934B; CN108209934A

Abstract

An auditory sensitivity detection system based on stimulus-frequency otoacoustic emissions. The detection system comprises an audio card (2), an acoustic sensor (3), a computer (1) and a signal feedback device. An input end of a micro loudspeaker (31) is connected to the audio card (2); an output end of a micro microphone (32) is connected to the audio card (2); the signal feedback device is connected to the computer (1); an auditory sensitivity comprehensive detection system is provided in the computer (1); and a test execution system comprises an intensity sensitivity detection module based on SFOAEs and a frequency sensitivity detection module based on SFOAEs, wherein the intensity sensitivity detection module based on SFOAEs is used for determining an auditory intensity threshold value corresponding to a corresponding frequency point by detecting stimulus-frequency otoacoustic emission detection data at each frequency point, and the frequency sensitivity detection module based on SFOAEs is used for extracting a stimulus-frequency otoacoustic emission suppression tuning curve at a designated frequency point and determining the frequency sensitivity at the designated frequency point.

Description

Auditory sensitivity detection system based on stimulation frequency otoacoustic emission

Technical field

The present invention relates to an auditory detection system, and more particularly to an auditory sensitivity detection system for objective, quantitative, and comprehensive detection of intensity sensitivity and frequency sensitivity of an auditory system based on stimulation frequency otoacoustic emissions.

Background technique

Otoacoustic Emissions (OAEs) are weak audio energy generated in the inner ear cochlea, transmitted through the ossicular chain and tympanic membrane, and released into the external auditory canal. They are part of the normal function of the human ear. This phenomenon was first discovered in 1978 by British scholar David Kemp and applied to the clinic. The discovery of otoacoustic emission confirmed that the cochlea is used as the auditory terminal sensor, which can not only passively convert the external acoustic signal into a bioelectric signal, but also induces the auditory energy. At the same time, there is an active release process, which establishes that the cochlea is a two-way exchange. The theory of energy. Because the presence or absence of OAE has become an objective indicator to evaluate whether the function of the auditory peripheral system is intact, it provides a new concept and research direction for auditory physiology research, and its discovery has become one of the important breakthroughs in modern auditory physiology. According to the presence or absence of external stimuli, otoacoustic emissions can be divided into two categories: Spontaneous Otoacoustic Emissions (SOAEs) and Evoked Otoacoustic Emissions (EOAEs). EOAEs can be divided into Transient-Evoked Otoacoustic Emissions (TEOAEs), Distortion-Product Otoacoustic Emissions (DPOAEs) and Stimulus-frequency Otoacoustic Emissions (Stimulus). -Frequency Otoacoustic Emissions, SFOAEs).

At present, the auditory threshold intensity test adopts a subjective behavioral response audiometry method, for example, pure tone audiometry, which requires subjective cooperation and cannot objectively test infants and young children. The clinically used transient evoked otoacoustic emissions (TEOAEs) and distortion product otoacoustic emissions (DPOAEs) can only be qualitatively screened, giving the results of normal auditory peripheral function, and lack of intensity threshold identification. Quantitative detection results of sensitivity (referred to as: intensity sensitivity). Therefore, there is currently no clinically quantitative, objective, and comprehensive detection method for the intensity sensitivity of the auditory system. In addition, there is no objective, quantitative, and comprehensive detection method for the frequency identification sensitivity of the auditory system (referred to as: frequency sensitivity).

Stimulating frequency otoacoustic emissions (SFOAEs) are those in which the inner ear cochlea is stimulated by a single frequency signal and actively emits a weak acoustic signal at the same frequency as the stimuli. Because it can reflect the active mechanism of the outer hair cells of the cochlea, it further reflects the function of the auditory peripheral system. Therefore, stimulation frequency otoacoustic emissions have the potential to detect the function of the auditory system objectively, quantitatively, and non-invasively. Since the frequency of the stimulation frequency otoacoustic emission is exactly the same as the frequency of the stimulation sound, it is called the stimulation frequency otoacoustic emission. The intensity of the stimulus frequency otoacoustic emissions is very low, typically between -15dB SPL and +20dB SPL. The frequency sensitivity at a certain characteristic frequency can be characterized by the Q value of the tuning characteristic represented by the stimulation frequency otoacoustic emission suppression tuning curve. SFOAEs under pure tone stimulation are pure tones with the same frequency of stimulus, so the intensity of SFOAEs has the potential to objectively and quantitatively reflect the hearing threshold at a certain frequency. Since the SFOAEs signal and the stimuli signal are completely aliased in the frequency domain; and most of the time, the SFOAEs signal and the stimulus artifact are also aliased in the time domain. In addition, the intensity of the SFOAEs signal is extremely small relative to the intensity of the stimuli. Usually, the SFOAEs are 30 dB lower or more than the stimuli. Therefore, using the SFOAEs signal to quantitatively and objectively reflect the threshold of auditory intensity requires a more sophisticated detection technique to suppress the stimulus artifacts.

In the prior art, Patent Application No. 200910237175.3, entitled "A Portable Full-Featured Otoacoustic Emission Detection System" discloses a portable ear acoustic emission detection system based on a USB multimedia sound card, based on the VC++Studio 2005 software platform, Full-featured quantitative detection and analysis of transient evoked otoacoustic emissions (TEOAEs) and distorted otoacoustic emissions (DPOAEs) signals. However, this patent does not cover the detection of stimuli-frequency otoacoustic emissions, and the techniques and methods for the objective quantitative detection of the auditory system's intensity threshold using SFOAEs. At the same time, there is no technology related to the quantitative detection of the frequency sensitivity of the auditory system using SFOAE STCs. And the method; in addition, the patent application number is 201210333260.1, the invention name is "a stimulation frequency otoacoustic emission tuning curve detection and calibration system" only discloses the detection method of the stimulation frequency otoacoustic emission tuning curve and the detection technology of the calibration system, but There are no techniques and methods related to the objective, quantitative detection of the intensity threshold of the auditory system using stimulus frequency otoacoustic emissions, nor the detailed techniques and methods for quantitative detection of the frequency sensitivity of the auditory system using SFOAE STCs.

Summary of the invention

In view of the above problems, an object of the present invention is to provide an auditory sensitivity detecting system based on stimulation frequency otoacoustic emission, which can realize quantitative and objective detection of intensity threshold identification sensitivity at different frequencies not only by stimulation frequency otoacoustic emission test. Moreover, it is also possible to suppress the tuning curve by stimulating the frequency otoacoustic emission to complete the quantitative and objective detection of the frequency resolution sensitivity at different frequencies.

To achieve the above object, the present invention adopts the following technical solution: an auditory sensitivity detecting system based on stimulation frequency otoacoustic emissions, characterized in that the detection system comprises a sound card, an acoustic sensor and a computer, wherein the acoustic sensor comprises a microspeaker And a micro microphone; the computer is provided with an auditory sensitivity integrated detection system, including a sound card driving system and a test execution system; the sound card driving system is configured to drive the sound card to receive a signal from the computer, and pass the micro speaker Sending to the subject's ear; simultaneously driving the sound card to receive the signal sent back by the miniature microphone and transmitting it to the test execution system; the test execution system includes an SFOAEs-based intensity sensitivity detection module and SFOAEs-based a frequency sensitivity detecting module, wherein the SFOAEs-based intensity sensitivity detecting module is configured to determine an auditory intensity threshold corresponding to a corresponding frequency point by detecting stimulation frequency otoacoustic emission data of each frequency point; and the SFOAEs-based frequency sensitivity detecting module is used for Extract in the specified The stimulation frequency at the frequency point is used to suppress the tuning curve of the otoacoustic emissions, determining the frequency sensitivity at the specified frequency point.

Further, the SFOAEs-based intensity sensitivity detection module includes a stimulation sound parameter setting module, a suppression sound parameter setting module, a stimulation sound signal generation module, a suppression sound signal generation module, a stimulation sound signal stimulation module, a suppression sound signal stimulation module, and detection. a signal acquisition module, a signal processing module, a frequency domain waveform display module, a test data display module, an intensity sensitivity conversion module, and a test result report generation and saving module; the stimulation sound parameter setting module is configured to set a stimulation sound frequency, a frequency band range, and a stimulus The sound frequency test step size and the stimulation intensity; the suppression sound parameter setting module is configured to set the frequency and intensity of the suppression sound; the stimulation sound signal generation module and the suppression sound signal generation module respectively generate corresponding digital stimulation sounds according to the set parameters Signaling and digitally suppressing the acoustic signal and transmitting a corresponding signal to the stimulation acoustic signal stimulation module and the suppression acoustic signal stimulation module; the stimulation acoustic signal stimulation module and the suppression acoustic signal stimulation module emit a stimulation acoustic signal and a suppression acoustic signal via the sound card And miniature speakers Going to the ear of the subject, the miniature microphone receives a signal sent back from the external auditory canal of the subject, and then transmits the signal to the sound card, and the sound card transmits the signal to the detection signal acquisition module after performing A/D conversion. The detection signal acquisition module sends the collected signal to the signal processing module, and the signal processing module extracts the stimulation frequency otoacoustic emission at different stimulation frequencies, and sends the detection result to the frequency domain waveform display module, a test data display module, an intensity sensitivity conversion module, and a test result report generation and save module, the waveform display module dynamically displaying amplitude, baseline, phase, and noise waveforms of the detected data of the SFOAEs at different frequencies; the test data display module The dynamic display shows that the detection data of the SFOAEs at different frequencies includes amplitude, waveform, phase, baseline, and noise. The intensity sensitivity conversion module groups according to the detection frequency, and performs cluster analysis according to amplitude, waveform, baseline, and noise in each group. According to the prior mathematical relationship model, the specific intensity is obtained. Value; the test result and save report generation module for generating a detection result and save all the information and the test subject.

Further, the specific calculation process of the intensity sensitivity conversion module is divided into four categories according to the signal spectrum appearing at the detection frequency:

The first category: no pure audio spectrum appears or the signal to noise ratio is below 0 dB;

The second category: pure audio spectrum appears and the signal to noise ratio is higher than 10dB;

The third category: pure audio spectrum appears and the signal to noise ratio is between 5dB and 10dB;

The fourth category: pure audio spectrum appears and the signal to noise ratio is between 5dB and 0dB;

For the first type of secondary classification, if there is no pure audio spectrum, it is judged as detection failure, re-detection or frequency detection. For signal-to-noise ratio lower than 0dB but higher than the baseline by 6dB, the SFOAEs intensity sensitivity = a*( SFOAE amplitude - baseline amplitude), a value is set according to the frequency;

For the second category, a pure audio spectrum appears with a signal-to-noise ratio above 10 dB for secondary classification. For baselines above noise greater than 3 dB, SFOAEs intensity sensitivity = b* (SFOAE amplitude - baseline amplitude) + c* (SFOAE baseline) Amplitude-noise amplitude), b and c values are set according to the frequency; if the baseline is greater than the noise value less than 3dB, the SFOAEs intensity sensitivity mathematical model = d * (SFOAE amplitude - baseline amplitude), d value according to the frequency Setting

For the third category, a pure audio spectrum appears with a signal-to-noise ratio between 5 dB and 10 dB for secondary classification. For baselines above noise, SFOAEs intensity sensitivity = e* (SFOAE amplitude - f * baseline amplitude), for If the baseline is lower than the noise, the SFOAEs intensity sensitivity = g * (SFOAE amplitude - h * noise amplitude), e, f, g, h values are set according to the frequency;

For the fourth category, a pure audio spectrum appears with a signal-to-noise ratio between 5 dB and 0 dB for secondary classification. For baselines above noise, the SFOAEs intensity sensitivity = i* (SFOAE amplitude - j * noise amplitude), For baselines below noise, SFOAEs intensity sensitivity = k * (SFOAE amplitude - l * baseline amplitude), i, j, k, l values are set according to the frequency.

Further, the SFOAEs frequency sensitivity detecting module comprises a stimulation sound parameter setting module, a suppression sound parameter setting module, a stimulation sound signal generation module, a suppression sound signal generation module, a stimulation sound signal stimulation module, a suppression sound signal stimulation module, and a detection signal collection. Module, detection signal processing module, SFOAE STCs waveform display module, test data display module, frequency sensitivity conversion module, test result report generation and save module; the stimulation sound parameter setting module is used to set the stimulation sound frequency and the stimulation sound intensity; The suppression sound parameter setting module is configured to set an upper limit of the suppression sound frequency, a lower limit of the suppression sound frequency, a suppression sound frequency step size, and a suppression criterion; the stimulation sound signal generation module and the suppression sound signal generation module generate corresponding digital stimulation according to the set parameters. a signal and a digital suppression signal; the stimulation sound signal stimulation module and the suppression sound signal stimulation module emit a stimulation sound at a stimulation frequency and a suppression sound of different frequencies and different intensities to the ear of the subject via the sound card and the microspeaker, and suppress the sound Frequency of stimulation The left and right ranges are adjusted in a set suppression sound frequency step. The micro microphone amplifies the signal in the ear canal and sends the signal to the sound card, and finally transmits the signal to the detection signal processing module via the detection signal acquisition module. The detection signal processing module extracts a test result of obtaining a SFOAE STCs curve by using a stimulus frequency otoacoustic emission satisfying a set suppression criterion at each suppression frequency within a range of the suppression sound frequency, wherein the SFOAE STCs waveform display module is configured to display a test waveform; The test data display module dynamically displays the detection data of the SFOAE STCs at different frequencies, and the frequency sensitivity conversion module groups the detection frequencies, and performs cluster classification according to the amplitude, waveform, baseline and noise of the SFOAE STCs curve in each group. And according to the a priori mathematical relationship model, a specific frequency sensitivity value is obtained; the test result report generation and saving module is used to generate and save all the test results and test information of the subject.

Further, the specific calculation process of the frequency sensitivity conversion module is: according to the shape and position of the SFOAE STCs curve appearing at the detection frequency, the first type is the SFOAE STCs curve with double vertices, and the second type is the appearance list. SFOAE STCs curve of the apex;

For the first category, the SFOAE STCs curve with double vertices is sub-classified. If the apex is higher than the stimulus intensity, the frequency sensitivity = a*Q10+b* high-end slope-c* low-end slope, if the apex is lower than the stimuli Intensity, then frequency sensitivity = a * Q10;

For the second type of SFOAE STCs curve with a single vertex, if the right offset, the frequency sensitivity = d * Q10 + e * (high end slope - f * low end slope), if left offset, the frequency sensitivity = g * Q10 +h* (high-end slope), if there is no offset, the frequency sensitivity = i * Q10, where Q10 refers to the quality factor of 10dB point, according to the detected frequency, select different a, b, c, d, e , f, g, and h values.

Further, the detection system further includes a pure tone audiometry detection module with a resolution of 1 dB, and the pure tone audiometry detection module uses a subjective behavior method to obtain a hearing threshold with a resolution of 1 dB at each frequency point, and is used for The results of the SFOAEs intensity sensitivity detection module were compared to establish a model relationship between the intensity detection based on SFOAEs and the auditory threshold of pure tone audiometry.

Further, the detection system further comprises a psychophysical tuning curve detection module, wherein the psychophysical tuning curve detection module uses a subjective behavior method to obtain a frequency sensitivity at a specified frequency point for comparison with a result based on the SFOAEs frequency sensitivity detection module. By establishing a model relationship between the frequency sensitivity detection results based on SFOAEs and the frequency sensitivity detection results of PTCs.

Further, the detection system further includes a preamplifier, an input end of the preamplifier is connected to an output end of the micro microphone, and an output end of the preamplifier is connected to the sound card.

Further, the detection system further includes a signal feedback device coupled to the computer for signal feedback by the subject and transmitting feedback results of the subject to the computer; the signal feedback device employing A handle that connects to the computer via a USB interface.

The invention adopts the above technical solutions, and has the following advantages: 1. The test module based on the SFOAEs intensity sensitivity of the present invention (including the conventional test module and the test module at the designated frequency point) is used for objective, quantitative and rapid extraction. The intensity sensitivity at the frequency point enables clinically objective detection of the hearing threshold. 2. The test based on the stimulation frequency otoacoustic emission suppression tuning curve (SFOAE STCs) of the present invention realizes quantitative and objective detection of frequency resolution sensitivity at different frequencies, and psychophysical tuning curves (PTCs) corresponding to subjective behavioral responses. The resolution of the detected frequency sensitivity is compared, and the quantitative detection of the frequency resolution sensitivity can be realized clinically. 3. The present invention extracts a weak SFOAEs signal in the frequency domain and time domain of the SFOAEs, and extracts the weak SFOAEs signal, and uses the intensity of the SFOAEs signal to objectively and quantitatively reflect the intensity sensitivity (hearing threshold) of the auditory system. Stimulus frequency Otoacoustic emission suppression tuning curve (SFOAE STCs) is a tuning curve at a certain stimulation frequency, with the potential to reflect the sensitivity of the cochlear resolution frequency at this frequency, using SFOAE STCs to objectively and quantitatively reflect the frequency sensitivity of the auditory system. In summary, the SFOAEs-based intensity sensitivity and frequency sensitivity test of the present invention achieve objective, quantitative, comprehensive, and rapid detection of the auditory system, and have broad prospects for auditory clinical application.

DRAWINGS

Figure 1 is a schematic view of the overall structure of the present invention;

2 is a schematic diagram of the principle of the test execution system of the present invention;

3 is a schematic diagram of the principle of the intensity sensitivity constant detection module based on SFOAEs of the present invention;

4 is a schematic diagram of the principle of the frequency sensitivity detecting module based on SFOAE STCs of the present invention;

5 is a schematic flow chart of a pure tone audiometry detection module with a resolution of 1 dB according to the present invention;

Figure 6 is a flow chart showing the detection module of the psychophysical tuning curve (PTCs) of the present invention.

Detailed ways

The invention is described in detail below with reference to the accompanying drawings. It is to be understood, however, that the appended claims

As shown in FIG. 1 , the present invention provides an auditory sensitivity detection system based on stimulation frequency otoacoustic emission for acquiring intensity sensitivity and frequency sensitivity of stimulation frequency otoacoustic emissions, including computer 1, sound card 2, and acoustic sensor (micro probe). 3. A preamplifier and a signal feedback device; wherein the acoustic sensor 3 includes a microspeaker 31 and a microspeaker 32, and the microspeaker 31 and the microspeaker 32 can be inserted in the same in order to isolate the sound in the external auditory canal of the subject from the external sound. Inside the soft earplugs.

The sound card 2 adopts a multimedia sound card capable of connecting with the computer 1 for converting the digital signal sent by the computer 1 into an analog voltage signal. The present invention adopts a sampling depth of 24 bits and a maximum sampling rate of 192 kHz produced by RME. The portable multimedia sound card is connected to the computer 1 through the IEEE 1394 interface. For example, the sound card 2 can also adopt other structural forms and connection modes, such as a multimedia sound card or a normal sound card of the computer 1 through a USB interface.

The micro-speaker 31 includes two electro-acoustic transducers for respectively generating a stimulation sound and a suppression sound for inducing a stimulation frequency otoacoustic emission signal, and two electro-acoustic transducers are inserted into the earplug through two sound tubes, two The input end of the electro-acoustic transducer is respectively connected to the sound card 2 through two TRS interfaces, and is used for electroacoustic conversion of the analog voltage signal into an acoustic signal, which is sent to the ear of the subject via the earplug. The microspeaker 31 can be used in various products of the prior art, such as the ER2 plug-in earphone manufactured by Etymotic Co., Ltd. when the invention is tested.

The micro-microphone 32 includes an acoustic-electric transducer for collecting an otoacoustic emission signal and other signals in the external auditory canal of the human ear, and converting the collected acoustic signal into an electrical signal, and the input end of the micro-microphone 32 is inserted through the transmission sound tube. Set in the earplug, the sound signal in the ear canal converts the acoustic signal into an analog voltage signal by transmitting a sound tube to the acoustic-electric transducer, and the output of the micro-microphone 32 is connected to the input of the preamplifier. The micro-microphone 32 can be used in various products of the prior art. For example, the ER-10B+ manufactured by Etymotic Corporation of the United States is used for the detection of the present invention.

The preamplifier is used to amplify the signal output from the micro microphone 32, and the amplification factor can be adjusted according to actual needs, and the adjustment multiple can be selected to be 0 dB, 20 dB, and 40 dB. In order to avoid signal interference caused by the ground loop, the preamplifier is powered by two 9V batteries, and the output of the preamplifier is connected to the sound card 2.

The signal feedback device is connected to the computer 1 for the feedback of the subject and the feedback result of the subject is sent to the computer 1. The signal feedback device can adopt various devices. The signal feedback device of the present invention adopts the handle 4, and the handle 4 passes. The USB interface is connected to the computer 1.

As shown in FIG. 2, the computer 1 is provided with an auditory sensitivity comprehensive detection system, including a sound card driving system and a test execution system. The sound card driving system is used to drive the sound card 2 to receive the signal from the computer 1 and transmit it to the ear of the subject through the micro speaker 31; at the same time, the sound card 2 is driven to receive the signal sent back by the preamplifier and send it to the test execution system. .

The test execution system includes an SFOAEs-based intensity sensitivity detection module, a SFOAEs-based frequency sensitivity detection module, a 1 dB resolution pure tone audiometry (PT) detection module, and a psychophysical tuning curve (PTCs) based detection module.

The detection module of the intensity sensitivity based on the SFOAEs is used to determine the auditory intensity threshold corresponding to the corresponding frequency point by detecting the amplitude, waveform, baseline, phase, and noise of the stimulation frequency of the stimulation frequency at each frequency point;

A frequency sensitivity detection module based on SFOAEs is used to extract a stimulus frequency otoacoustic emission suppression tuning curve (SFOAE STCs) at a specified frequency point to determine a frequency sensitivity at a specified frequency point;

The pure tone audiometry detection module with resolution of 1dB uses the subjective behavior method to obtain the hearing threshold of 1dB resolution at each frequency point, which is used to compare with the results based on the SFOAEs intensity sensitivity detection module, and early to establish the intensity detection based on SFOAEs. The model relationship of the auditory threshold of pure tone audiometry, achieving SFOAEs-based intensity sensitivity detection consistent with clinical pure tone audiometry detection results;

The psychophysical tuning curve detection module uses the subjective behavior method to obtain the frequency sensitivity at the specified frequency point for comparison with the results based on the SFOAEs frequency sensitivity detection module. The frequency sensitivity detection results based on SFOAEs and the frequency sensitivity detection of PTCs are established in the early stage. The model relationship between the results is implemented in clinically based SFOAEs frequency sensitivity detection.

In a preferred embodiment, as shown in FIG. 3, the SFOAEs-based intensity sensitivity detection module is configured to test each frequency, including a stimulation sound parameter setting module, a suppression sound parameter setting module, a stimulation sound signal generation module, and a suppression sound. The signal generation module, the stimulation sound signal stimulation module, the suppression sound signal stimulation module, the detection signal acquisition module, the signal processing module, the frequency domain waveform display module, the test data display module, the intensity sensitivity conversion module, and the test result report generation and saving module. The stimulation sound parameter setting module is configured to set the frequency of the stimulation sound, the frequency band range, the stimulation sound frequency test step length and the stimulation intensity; the suppression sound parameter setting module is used to set the frequency and intensity of the suppression sound; the stimulation sound signal generation module and the suppression sound signal The generating module respectively generates corresponding digital stimulation sound signals and digital suppression sound signals according to the set parameters and sends corresponding signals to the stimulation sound signal stimulation module and the suppression sound signal stimulation module; the stimulation sound signal stimulation module and the suppression sound signal stimulation module emit the stimulation sound The signal and the suppression sound signal pass through the sound card 2 and the micro-speaker 31 to the ear of the subject, and the micro-microphone 32 receives the signal sent back from the external auditory canal of the subject, sends it to the preamplifier for amplification, and sends it to the sound card 2, and the sound card 2 will The signal is subjected to A/D conversion transmission detection signal acquisition module, and the detection signal acquisition module sends the collected signal to the signal processing module, and the signal processing module extracts the stimulation frequency otoacoustic emission at different stimulation frequencies, and sends the detection result to the frequency separately. Domain waveform display module, test data display module, strength Acuity test result conversion module and report generation and saving module. The waveform display module dynamically displays the amplitude, baseline, phase, and noise waveforms of the detected data of the SFOAEs at different frequencies; the test data display module dynamically displays the detected data (amplitude, waveform, phase, baseline, and noise) of the SFOAEs at different frequencies. The intensity sensitivity conversion module groups according to the detection frequency; performs cluster analysis according to amplitude, waveform, baseline and noise in each group, and then obtains specific intensity sensitivity value according to the prior mathematical relationship model; test result report generation and save module Used to generate and save all test results and test information of the subject.

In a preferred embodiment, the intensity sensitivity conversion module groups according to the detection frequency, performs cluster analysis according to amplitude, waveform, baseline and noise in each group, and then obtains a specific intensity sensitivity value according to the prior mathematical relationship model. The specific process is:

According to the signal spectrum appearing at the detection frequency, it is divided into four categories:

The first category: no pure tone signal spectrum appears or the signal to noise ratio is below 0 dB;

The fourth category: pure audio spectrum appears and the signal to noise ratio is between 5dB-0;

In the first category, the second classification is performed. If the pure tone signal spectrum does not appear, it is judged as detection failure, re-detection or frequency change detection (possibly overlapping with SOAE), and the signal-to-noise ratio is lower than 0 dB but high. At 6dB from the baseline, the SFOAEs intensity sensitivity = a* (SFOAE amplitude - baseline amplitude), a value is set according to the frequency;

For the second category, a pure audio spectrum appears with a signal-to-noise ratio higher than 10 dB, and then a second classification. For baselines above noise greater than 3 dB, SFOAEs intensity sensitivity = b* (SFOAE amplitude - baseline amplitude) + c * ( SFOAE baseline amplitude - noise amplitude), select the appropriate b and c values according to the detected frequency; for the baseline greater than the noise value less than 3dB, the SFOAEs intensity sensitivity mathematical model = d * (SFOAE amplitude - baseline amplitude). Different d values are selected according to the detected frequencies;

For the third category, a pure audio spectrum appears with a signal-to-noise ratio between 5 dB and 10 dB, and then a second classification. For baselines above noise, the SFOAEs intensity sensitivity = e* (SFOAE amplitude - f * baseline amplitude) For baselines below noise, SFOAEs intensity sensitivity = g * (SFOAE amplitude - h * noise amplitude) according to the detected frequency, select different e, f, g, h values;

For the fourth category, pure audio spectrum appears and the signal-to-noise ratio is between 5dB-0; then the second classification is performed. For the baseline higher than the noise, the SFOAEs intensity sensitivity = i* (SFOAE amplitude - j * noise amplitude) For baselines below noise, SFOAEs intensity sensitivity = k * (SFOAE amplitude - l * baseline amplitude), depending on the frequency detected, select different i, j, k, l values

In a preferred embodiment, as shown in FIG. 4, the SFOAEs frequency sensitivity detecting module includes a stimulation sound parameter setting module, a suppression sound parameter setting module, a stimulation sound signal generation module, a suppression sound signal generation module, a stimulation sound signal stimulation module, The suppression sound signal stimulation module, the detection signal acquisition module, the detection signal processing module, the SFOAE STCs waveform display module, the test data display module, the frequency sensitivity conversion module, the test result report generation and the saving module. The stimulation sound parameter setting module is configured to set the stimulation sound frequency and the stimulation sound intensity; the suppression sound parameter setting module is configured to set the suppression sound frequency upper limit, the suppression sound frequency lower limit, the suppression sound frequency step size and the suppression criterion; the stimulation sound signal generation module and the suppression The acoustic signal generating module generates a corresponding digital stimulation signal and a digital suppression signal according to the set parameters; the stimulation sound signal stimulation module and the suppression sound signal stimulation module emit the stimulation sound at the stimulation frequency and the different frequencies and different intensities through the sound card 2 and the micro speaker 31. The sound is suppressed to the ear of the subject, and the frequency of the suppression sound is adjusted in the range of the suppression sound frequency in the range of the stimulation frequency, and the micro microphone 32 transmits the signal in the ear canal to the sound card 2 through the preamplifier, and finally The detection signal acquisition module transmits to the detection signal processing module, and the detection signal processing module extracts the stimulation frequency otoacoustic emission that satisfies the set suppression criterion at each suppression frequency within the suppression sound frequency range, and the specific process is: continuously increasing or decreasing the suppression sound Intensity, when the stimulus frequency otoacoustic emission residual amount reaches the setting When the adjustment is stopped, the point at this time (the corresponding suppression frequency point and suppression intensity) is the point in the tuning frequency otoacoustic emission tuning curve; and so on to measure the next suppression frequency point, the acoustic frequency range will be suppressed. The point-by-point connection of each point under different suppression frequencies is the test result of the stimulation frequency otoacoustic emission tuning curve. The SFOAE STCs waveform display module is used to display the test waveform; the test data display module dynamically displays the SFOAE STCs at different frequencies. Detecting data (amplitude, baseline, and noise); the frequency sensitivity conversion module first groups according to the detection frequency; then, within each group, clusters are classified according to the amplitude, waveform, baseline, and noise of the SFOAE STCs curve; in different classes, according to The prior mathematical relationship model is used to derive specific frequency sensitivity values; the test result report generation and preservation module is used to generate and save all test results and test information of the subject.

In a preferred embodiment, the frequency sensitivity conversion module first groups according to the detection frequency; then, within each group, clusters are classified according to the amplitude, waveform, baseline, and noise of the SFOAE STCs curve; in different classes, according to the priori The mathematical relationship model, the specific process of obtaining specific frequency sensitivity values is:

According to the shape and position of the SFOAE STCs curve appearing at the detection frequency, there are two types, and the SFOAE STCs curve of the double vertices and the single vertices appear.

For the first category, the SFOAE STCs curve with double vertices appears, and then the second classification. If the apex is higher than the stimuli, the frequency sensitivity = a * Q10 (quality factor of 10dB point) + b * high end slope - c * low End slope, if the apex is lower than the stimulus intensity, the frequency sensitivity = a * Q10 (quality factor of 10dB point);

2) For the second type of SFOAE STCs curve with a single vertex, if the right offset, the frequency sensitivity = d * Q10 (quality factor of 10Db point) + e * (high end slope - f * low end slope), if left bias Shift, frequency sensitivity = g * Q10 (quality factor of 10Db point) + h * (high end slope), if there is no offset, frequency sensitivity = i * Q10 (quality factor of 10Db point), depending on the detected frequency, Different values of a, b, c, d, e, f, g, and h are selected.

In a preferred embodiment, as shown in FIG. 5, the pure tone audiometry detection module with a resolution of 1 dB includes a handle configuration module, a feedback signal receiving module, a test type selection module, a test parameter selection module, a test control analysis module, and a pure tone. The signal stimulation module, the result analysis module and the display module; the handle configuration module is configured to bind the button of the handle 4, and send the binding configuration result to the feedback signal receiving module; the test type selection module is used to select the test type (available The selected test types include: ascending method and lifting method; the test parameter selection module is used to set the test method, test frequency and pure tone intensity upper and lower limits; the test control analysis module sends the test frequency and pure tone according to the selected test method and test parameters. The test intensity is sent to the pure tone signal stimulation module, and the pure tone signal stimulation module sends the digital pure tone stimulation signal to the subject's ear. The feedback signal receiving module receives the judgment result fed back by the subject through the handle button, and sends the judgment result back to the test control analysis. Module, test control analysis module increases according to the result Add or reduce the pure tone strength, obtain the hearing threshold under the stimulation of the pure tone signal, and send it to the result analysis module for saving or updating, and determine whether the hearing thresholds of all the test frequencies have been obtained; if all have been obtained, draw The audiogram is sent to the display module for display. The pure tone audiometry detection module with a resolution of 1dB is used to establish a mathematical model relationship with the SFOAEs based strength test results in the previous large data volume analysis to achieve a pure tone with clinical results. SFOAEs-based intensity sensitivity detection with consistent audiometry results.

In a preferred embodiment, as shown in FIG. 6, the detection module based on the psychophysical tuning curve includes a handle configuration module, a test parameter selection module, a test signal generation module, a test control module, a test signal stimulation module, and a feedback signal receiving module. The result analysis module and the display module; the handle configuration module is configured to bind the button of the handle 4, and send the binding configuration result to the feedback signal receiving module; the test parameter selection module sets the stimulation sound frequency, the stimulation sound intensity and the masking sound The upper limit of the intensity; the test signal generation module generates a pure tone stimulation sound and a sweep narrowband masking sound according to the received test parameters, and sends the sound to the test control module, and the test control module sends a signal to the test signal stimulation module to make the stimulus sound and Masking sound; the feedback signal receiving module receives the judgment result fed back by the subject through the handle button, and sends the judgment result back to the test control module, which increases or decreases the masking sound intensity according to the result, and records the masking sound intensity in real time, and records The value is sent to the result analysis module, the result The analysis module draws a masking sound intensity variation map, and performs smoothing and positive and negative averaging processing to obtain a psychophysical tuning curve, and sends it to the display module for display. The frequency sensitivity detection module based on the psychophysical tuning curve is used in the early stage. In the large data volume analysis, a mathematical model relationship is established with the test results of the SFOAEs-based suppression tuning curve, in order to prepare for the detection result of the frequency sensitivity based on the SFOAE STCs,

In a preferred embodiment, the detection signal acquisition module of the SFOAEs-based intensity sensitivity detection module and the SFOAEs-based frequency sensitivity detection module, ie, the test signal extraction of the stimulation frequency otoacoustic emission, the method for extracting the stimulation frequency otoacoustic emission is basically the same, It mainly includes three existing methods: nonlinear compression, dual tone suppression, and spectral smoothing. Each method uses a different cochlear phenomenon or signal processing technique to extract the stimulus frequency otoacoustic emissions, where nonlinear compression The method makes full use of the linear growth relationship between the compression growth of the stimulus frequency otoacoustic emission amplitude and the stimulation sound; the two-tone suppression method defines the SFOAEs as the ear canal detected near the stimulation frequency, increasing the suppression sound and not increasing the suppression sound. The composite difference between sound pressures, it is considered that the suppression sound can greatly reduce or remove the otoacoustic emission; the spectral smoothing process uses the smoothing function to convolve the spectrum of the composite ear canal sound pressure, and the analysis method utilizes the stimulation sound and The latency of otoacoustic emissions is different, equivalent to adding in the corresponding latency period .

The above embodiments are only used to illustrate the present invention, wherein the structure, the connection method, the manufacturing process, and the like of the components may be varied. Any equivalent transformation and improvement based on the technical solution of the present invention should not be used. It is excluded from the scope of protection of the present invention.

Claims

An auditory sensitivity detecting system based on stimulation frequency otoacoustic emission, characterized in that the detection system comprises a sound card, an acoustic sensor and a computer, wherein the acoustic sensor comprises a microspeaker and a micro microphone; the computer is provided with auditory sensitivity Integrated detection system, including sound card drive system and test execution system;

The sound card driving system is configured to drive the sound card to receive a signal sent by the computer, and send the signal to the ear of the subject through the micro speaker; and simultaneously drive the sound card to receive a signal sent back by the micro microphone, and Send it to the test execution system;

The test execution system includes an SFOAEs-based intensity sensitivity detection module and a SFOAEs-based frequency sensitivity detection module, and the SFOAEs-based intensity sensitivity detection module is configured to determine a corresponding frequency point by detecting stimulation frequency otoacoustic emission data at each frequency point. Corresponding auditory intensity threshold; the SFOAEs-based frequency sensitivity detection module is configured to extract a stimulation frequency otoacoustic emission suppression tuning curve at a specified frequency point, and determine a frequency sensitivity at a specified frequency point.
The hearing sensitivity detecting system based on the stimulation frequency otoacoustic emission according to claim 1, wherein the SFOAEs-based intensity sensitivity detecting module comprises a stimulation sound parameter setting module, a suppression sound parameter setting module, a stimulation sound signal generating module, Suppression acoustic signal generation module, stimulation acoustic signal stimulation module, suppression acoustic signal stimulation module, detection signal acquisition module, signal processing module, frequency domain waveform display module, test data display module, intensity sensitivity conversion module, and test result report generation and saving module ;

The stimulation sound parameter setting module is configured to set a stimulation sound frequency, a frequency band range, a stimulation sound frequency test step length, and a stimulation intensity; the suppression sound parameter setting module is configured to set a frequency and an intensity of the suppression sound; and the stimulation sound signal generation The module and the suppression sound signal generating module respectively generate corresponding digital stimulation sound signals and digital suppression sound signals according to the set parameters and send corresponding signals to the stimulation sound signal stimulation module and the suppression sound signal stimulation module; the stimulation sound signal stimulation module And suppressing the acoustic signal stimulation module to emit the stimulation sound signal and the suppression sound signal through the sound card and the micro-speaker to the ear of the subject, the micro-microphone receiving the signal sent back from the external auditory canal of the subject, and then transmitting the signal to the sound card, The sound card sends the signal to the detection signal acquisition module after A/D conversion, and the detection signal acquisition module sends the collected signal to the signal processing module, and the signal processing module extracts different stimulation frequencies. Stimulating frequency otoacoustic emissions and transmitting the detection results to the frequency domain waveform display a module, a test data display module, an intensity sensitivity conversion module, and a test result report generation and save module, the waveform display module dynamically displaying amplitude, baseline, phase, and noise waveforms of the detected data of the SFOAEs at different frequencies; the test data The display module dynamically displays the detection data of the SFOAEs at different frequencies including amplitude, waveform, phase, baseline, and noise. The intensity sensitivity conversion module groups according to the detection frequency, and clusters according to amplitude, waveform, baseline, and noise in each group. Analysis, and then based on the prior mathematical relationship model, to obtain a specific intensity sensitivity value; the test result report generation and preservation module is used to generate and save all test results and test information of the subject.
The auditory sensitivity detecting system based on stimulation frequency otoacoustic emissions according to claim 2, wherein the specific calculation process of the intensity sensitivity conversion module is divided into four categories according to a signal spectrum appearing at the detection frequency:

The first category: no pure audio spectrum appears or the signal to noise ratio is below 0 dB;

The second category: pure audio spectrum appears and the signal to noise ratio is higher than 10dB;

The third category: pure audio spectrum appears and the signal to noise ratio is between 5dB and 10dB;

The fourth category: pure audio spectrum appears and the signal to noise ratio is between 5dB and 0dB;

For the first type of secondary classification, if there is no pure audio spectrum, it is judged as detection failure, re-detection or frequency detection. For signal-to-noise ratio lower than 0dB but higher than the baseline by 6dB, the SFOAEs intensity sensitivity = a*( SFOAE amplitude - baseline amplitude), a value is set according to the frequency;

For the second category, a pure audio spectrum appears with a signal-to-noise ratio above 10 dB for secondary classification. For baselines above noise greater than 3 dB, SFOAEs intensity sensitivity = b* (SFOAE amplitude - baseline amplitude) + c* (SFOAE baseline) Amplitude-noise amplitude), b and c values are set according to the frequency; if the baseline is greater than the noise value less than 3dB, the SFOAEs intensity sensitivity mathematical model = d * (SFOAE amplitude - baseline amplitude), d value according to the frequency Setting

For the third category, a pure audio spectrum appears with a signal-to-noise ratio between 5 dB and 10 dB for secondary classification. For baselines above noise, SFOAEs intensity sensitivity = e* (SFOAE amplitude - f * baseline amplitude), for If the baseline is lower than the noise, the SFOAEs intensity sensitivity = g * (SFOAE amplitude - h * noise amplitude), e, f, g, h values are set according to the frequency;

For the fourth category, a pure audio spectrum appears with a signal-to-noise ratio between 5 dB and 0 dB for secondary classification. For baselines above noise, the SFOAEs intensity sensitivity = i* (SFOAE amplitude - j * noise amplitude), For baselines below noise, SFOAEs intensity sensitivity = k * (SFOAE amplitude - l * baseline amplitude), i, j, k, l values are set according to the frequency.
The auditory sensitivity detecting system based on stimulation frequency otoacoustic emission according to claim 1 or 2, wherein the SFOAEs frequency sensitivity detecting module comprises a stimulation sound parameter setting module, a suppression sound parameter setting module, a stimulation sound signal generation module, Suppression acoustic signal generation module, stimulation acoustic signal stimulation module, suppression acoustic signal stimulation module, detection signal acquisition module, detection signal processing module, SFOAE STCs waveform display module, test data display module, frequency sensitivity conversion module, test result report generation and preservation The stimulation sound parameter setting module is configured to set a stimulation sound frequency and a stimulation sound intensity; the suppression sound parameter setting module is configured to set an upper limit of the suppression sound frequency, a lower limit of the suppression sound frequency, a suppression sound frequency step size, and a suppression criterion; The stimulation sound signal generation module and the suppression sound signal generation module generate corresponding digital stimulation signals and digital suppression signals according to the set parameters; the stimulation sound signal stimulation module and the suppression sound signal stimulation module emit stimulation frequencies via the sound card and the micro speaker Under stimulation And the suppression sound of different intensities of different frequencies is in the ear of the subject, and the frequency of the suppression sound is adjusted in a range of the suppression sound frequency in the range of the stimulation frequency, and the micro microphone amplifies the signal in the ear canal and transmits The sound card is finally transmitted to the detection signal processing module via the detection signal acquisition module, and the detection signal processing module extracts a stimulation frequency otoacoustic emission that satisfies the set suppression criterion at each suppression frequency within the suppression sound frequency range. Obtaining a test result of a SFOAE STCs curve display module for displaying a test waveform; the test data display module dynamically displaying detection data of the SFOAE STCs at different frequencies, the frequency sensitivity conversion module grouping the detection frequencies According to the amplitude, waveform, baseline and noise of the SFOAE STCs curve, cluster classification is performed in each group, and the specific frequency sensitivity value is obtained according to the a priori mathematical relationship model; the test result report generation and saving module is used to generate And save all test results and test information of the subject.
The auditory sensitivity detecting system based on stimulation frequency otoacoustic emission according to claim 4, wherein the specific calculation process of the frequency sensitivity conversion module is divided into two types according to the shape and position of the SFOAE STCs curve appearing at the detection frequency. The first type is the SFOAE STCs curve with double vertices, and the second is the SFOAE STCs curve with single vertices;

For the first category, the SFOAE STCs curve with double vertices is sub-classified. If the apex is higher than the stimulus intensity, the frequency sensitivity = a*Q10+b* high-end slope-c* low-end slope, if the apex is lower than the stimuli Intensity, then frequency sensitivity = a * Q10;

For the second type of SFOAE STCs curve with a single vertex, if the right offset, the frequency sensitivity = d * Q10 + e * (high end slope - f * low end slope), if left offset, the frequency sensitivity = g * Q10 +h* (high-end slope), if there is no offset, the frequency sensitivity = i * Q10, where Q10 refers to the quality factor of 10dB point, according to the detected frequency, select different a, b, c, d, e , f, g, and h values.
The auditory sensitivity detection system based on stimulation frequency otoacoustic emission according to claim 1, wherein the detection system further comprises a pure tone audiometry detection module with a resolution of 1 dB, and the pure tone audiometry detection module obtains a subjective behavior method. A hearing threshold of 1 dB at each frequency point is used for comparison with the results of the SFOAEs based intensity sensitivity detection module to establish a model relationship between the intensity detection based on SFOAEs and the auditory threshold of pure tone audiometry.
The auditory sensitivity detection system based on stimulation frequency otoacoustic emission according to claim 1, wherein the detection system further comprises a psychophysical tuning curve detecting module, wherein the psychophysical tuning curve detecting module obtains the specified frequency by using a subjective behavior method. The frequency sensitivity at the point is compared with the results based on the SFOAEs frequency sensitivity detection module, and the model relationship between the frequency sensitivity detection results based on SFOAEs and the frequency sensitivity detection results of PTCs is established.
A hearing sensitivity detection system based on stimulation frequency otoacoustic emissions as claimed in claim 1 wherein the detection system further comprises a preamplifier, the input of the preamplifier being coupled to the output of the miniature microphone, The output of the preamplifier is connected to the sound card.
A hearing sensitivity detection system based on stimulation frequency otoacoustic emissions as claimed in claim 6 wherein the detection system further comprises signal feedback means coupled to the computer for signal feedback by the subject The feedback results of the subject are sent to the computer; the signal feedback device employs a handle that is connected to the computer via a USB interface.